Signaling Pathway Analysis and Disease Modeling in Zebrafish

Dear Colleagues,

In the last number of years, the number of zebrafish (Danio rerio)-based tools to model both inherited and non-communicable human disease has grown exponentially. Due to its optical clarity and suitability for gene targeting and transgenesis, this organism is offering the unique possibility of combining disease-specific knock-down, knock-out and knock-in conditions with the real-time visualization of signaling pathway activation, performed at the whole-animal level. A plethora of mutant and transgenic lines are now available or currently under production, to model and analyze Mendelian diseases, as well as mitochondrial, multi-factorial and environmental conditions. These systems start to be exploited not only to clarify the pathogenetic mechanisms, but also to test and validate a wide range of new drug treatments, gene/cell-based approaches and bioengineered nanotherapies.

This Special Issue aims to summarize the current knowledge on zebrafish-based tools and their application to analyze cell signaling and to model and cure human disease.

We look forward to your contributions.

Prof. Natascia Tiso
Prof. Francesco Argenton
Guest Editor

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