Special Issue "Signaling Pathway Analysis and Disease Modeling in Zebrafish"
Deadline for manuscript submissions: 30 September 2020.
Interests: zebrafish; heart disease; mitochondrial disease; endocrine disease; melanoma; neural development; pancreatic development and cancer
Interests: zebrafish; cell fate decisions in pancreatic and neural development; genetic reporters for cellular studies
In the last number of years, the number of zebrafish (Danio rerio)-based tools to model both inherited and non-communicable human disease has grown exponentially. Due to its optical clarity and suitability for gene targeting and transgenesis, this organism is offering the unique possibility of combining disease-specific knock-down, knock-out and knock-in conditions with the real-time visualization of signaling pathway activation, performed at the whole-animal level. A plethora of mutant and transgenic lines are now available or currently under production, to model and analyze Mendelian diseases, as well as mitochondrial, multi-factorial and environmental conditions. These systems start to be exploited not only to clarify the pathogenetic mechanisms, but also to test and validate a wide range of new drug treatments, gene/cell-based approaches and bioengineered nanotherapies.
This Special Issue aims to summarize the current knowledge on zebrafish-based tools and their application to analyze cell signaling and to model and cure human disease.
We look forward to your contributions.
Prof. Natascia Tiso
Prof. Francesco Argenton
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- signaling pathway
- disease model
- mutant line
- transgenic reporter