The Interaction of Biomedical Nanoparticles with the Immune System
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 32138
Special Issue Editors
Interests: medicinal chemistry; inflammation; endocrine-disrupting chemicals; nanoparticles; oxidative stress; diabetes
Special Issues, Collections and Topics in MDPI journals
Interests: inflammation; innate immunity; host pathogen interaction; Pattern Recognition Receptors; T cells; T cell tolerance; autoimmunity
Interests: biological chemistry; antioxidants; anti-inflammatories; bioactive compounds; polyphenols
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nanomedicine has been opening a new avenue of research in cancer therapy, drug delivery, and immune regulation. Nevertheless, the use of nanoparticles is a double-edge sword. While the benefits of nanotechnology to human civilization are seemingly immeasurable, these particles can also lead to harmful effects to human health. In vivo studies have been showing that when nanoparticles enter the human body, they are immediately confronted with the innate immune system, activating cellular mechanisms involved in the inflammatory process. These mechanisms comprise the expression and activation of proinflammatory cytokines, chemokines, and adhesion molecules, with the recruitment of inflammatory cells including basophils, macrophages, dendritic cells, T cells, neutrophils, monocytes, and eosinophils. Thus, further research is needed to establish the extent of such inflammatory response and safe exposure levels to nanoparticles.
The present Special Issue is devoted to gathering the current understanding of the interaction of nanoparticles with the immune system, through original research articles on the inflammatory response to nanomaterials and critical review articles that scrutinize the current knowledge in this area, providing an expert platform of discussion.
Dr. Marisa Freitas
Dr. Francesca Granucci
Dr. Daniela Ribeiro
Guest Editors
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Keywords
- nanoparticles
- immune system
- inflammation
- risk assessment
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