Toxins, Volume 10, Issue 7 (July 2018) – 52 articles
Cover Story (view full-size image): The Mexican Lance-headed Rattlesnake (Crotalus polystictus) occupies native and modified grasslands in central México and feeds primarily on rodents. Ontogeny of the venom proteome follows a typical type I pattern, with neonates showing very low venom SVMP activity that increases dramatically as snakes age, while PLA2 shows the opposite pattern. Increases in SVMP activity with age are due to increases in PIII and PI metalloproteinases in adult venoms, as demonstrated via MALDI-TOF-MS/MS. Venom ontogeny appears to be driven by changes in prey size rather than type as was observed in other species such as Crotalus oreganus helleri and C. o. oreganus. (Photo by Estrella Mociño-Deloya and Kirk Setser) View this paper.
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