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Toxins 2018, 10(7), 296; https://doi.org/10.3390/toxins10070296

Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase Supplementation

1
Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, 38116 Braunschweig, Germany
2
BIOMIN Holding GmbH, BIOMIN Research Center, 3430 Tulln, Austria
3
Christian Doppler Laboratory for Mycotoxin Metabolism and Center for Analytical Chemistry, IFA, 3430 Tulln, Austria
4
Institute for Physiology, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany
5
Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany
Present Address: Romer Labs Diagnostic GmbH, 3430 Tulln, Austria.
*
Author to whom correspondence should be addressed.
Received: 29 May 2018 / Revised: 4 July 2018 / Accepted: 15 July 2018 / Published: 17 July 2018
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
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Abstract

The mycotoxin fumonisin B1 (FB1) is a frequent contaminant of feed. It causes a disruption of sphingolipid metabolism and pulmonary, hepatic, and immunological lesions in pigs depending on the exposure scenario. One sensitive biomarker for FB1 exposure is the sphinganine (Sa) to sphingosine (So) ratio in blood. The fumonisin esterase FumD, which can be used as a feed additive, converts FB1 into the much less toxic metabolite hydrolyzed FB1 (HFB1). We conducted a single-dose study with barrows allocated to one of five treatments: (1) control (feed, 0.9% NaCl intravenously iv), (2) 139 nmol FB1 or (3) HFB1/kg BW iv, (4) 3425 nmol FB1/kg BW orally (po), or (5) 3321 nmol FB1/kg BW and 240 U FumD/kg feed po. The Sa/So ratio of iv and po FB1 administered groups was significantly elevated in blood and Liquor cerebrospinalis, but no fumonisin-associated differences were reflected in other endpoints. Neither clinical lung affections nor histopathological pulmonary lesions were detected in either group, while some parameters of hematology and clinical biochemistry showed a treatment–time interaction. FumD application resulted in Sa/So ratios comparable to the control, indicating that the enzymatic treatment was effectively preventing the fumonisin-induced disruption of sphingolipid metabolism. View Full-Text
Keywords: fumonisin; pigs; Sa/So ratio; single-dose; clinical examination; blood count; clinical biochemistry; fumonisin esterase fumonisin; pigs; Sa/So ratio; single-dose; clinical examination; blood count; clinical biochemistry; fumonisin esterase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Schertz, H.; Dänicke, S.; Frahm, J.; Schatzmayr, D.; Dohnal, I.; Bichl, G.; Schwartz-Zimmermann, H.E.; Colicchia, S.; Breves, G.; Teifke, J.P.; Kluess, J. Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase Supplementation. Toxins 2018, 10, 296.

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