Special Issue "Adenylate Cyclase (CyaA) Toxin"
Deadline for manuscript submissions: closed (15 November 2017)
The adenylate cyclase (CyaA) toxin is produced by Bordetella pertussis, the causative agent of whooping cough. The incidence of pertussis is currently increasing and represents a global public health concern. Bordetella pertussis, a Gram-negative bacteria, was identified by Jules Bordet and Octave Gengou, who initially described “Le microbe de la coqueluche” in an article published in the Annales de l'Institut Pasteur in 1906. During the last few decades, multidisciplinary approaches have contributed to improve our knowledge on CyaA and showed that this toxin plays a crucial role in the early stages of respiratory tract colonization by disrupting the host immune response. CyaA is a 1706-residue long, multi-domain and bifunctional toxin containing a calmodulin-activated adenylate cyclase and a hemolysin. This toxin is the unique well-characterized bacterial toxin able to translocate its catalytic domain directly across the plasma membrane of target cells. The molecular mechanism by which CyaA intoxicates host cells remains, however, largely unknown. Recent advances worldwide open new perspectives for both basic sciences and CyaA-based biotechnological applications such as antigen delivery vehicles and CyaA-containing pertussis vaccines. These various aspects are discussed in this Special Issue of Toxins on the adenylate cyclase toxin.
Dr. Alexandre Chenal
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
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- Adenylate cyclase
- CyaA toxin
- bacterial toxin
- repeat in toxin
- RTX protein
- cell receptor
- membrane translocation
- calmodulin-stimulated enzyme, cAMP
- pertussis vaccine
- antigen delivery vehicle
- protein engineering
- innate immune response
- alveolar macrophage