Table of Contents
Toxins, Volume 10, Issue 6 (June 2018)
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Cover Story (view full-size image) Cone snails are predatory marine gastropods that use venom to catch preys and defend against [...] Read more. Cone snails are predatory marine gastropods that use venom to catch preys and defend against predators. In this issue, Giribaldi et al. synthesized and pharmacologically characterized two alpha-conotoxins from the piscivorous species Conus catus, namely CIA and CIB. CIA potently blocks the muscle type nicotinic acetylcholine receptor, whereas CIB inhibits neuronal subtypes. The 20 lowest energy NMR structures for CIB, superimposed over the backbone atoms, show a central α-helical region comprising residues 6-11. View Paper here.