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Toxins 2018, 10(7), 298; https://doi.org/10.3390/toxins10070298

Intestinal Barrier Function in Chronic Kidney Disease

1
Department of Microbiology and Immunology, KU Leuven, 3000 Leuven, Belgium
2
Division of Nephrology, UZ Leuven, 3000 Leuven, Belgium
3
Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 3000 Leuven, Belgium
4
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain
5
Laboratory of Translational Mucosal Immunology, Digestive Diseases Research Unit, Vall d’Hebron Institut de Recerca, 08035 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 16 July 2018 / Accepted: 18 July 2018 / Published: 19 July 2018
(This article belongs to the Special Issue The Intestine and Uremia)
Full-Text   |   PDF [12457 KB, uploaded 19 July 2018]   |  

Abstract

The kidneys are key contributors to body homeostasis, by virtue of controlled excretion of excessive fluid, electrolytes, and toxic waste products. The syndrome of uremia equals the altered physiology due to irreversible loss of kidney function that is left uncorrected for, despite therapeutic intervention(s). The intestines and its microbial content are prime contributors to this syndrome. The intestinal barrier separates the self (or the so-called “milieu intérior”) from the environment. In the large intestine, the intestinal barrier keeps apart human physiology and the microbiota. The enterocytes and the extracellular mucin layer functions form a complex multilayered structure, facilitating complex bidirectional metabolic and immunological crosstalk. The current review focuses on the intestinal barrier in chronic kidney disease (CKD). Loss of kidney function results in structural and functional alterations of the intestinal barrier, contribution to the syndrome of uremia. View Full-Text
Keywords: uremia; CKD; intestinal barrier; inflammation uremia; CKD; intestinal barrier; inflammation
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Meijers, B.; Farré, R.; Dejongh, S.; Vicario, M.; Evenepoel, P. Intestinal Barrier Function in Chronic Kidney Disease. Toxins 2018, 10, 298.

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