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Toxins 2018, 10(7), 303; https://doi.org/10.3390/toxins10070303

The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

1
Nephrology Department, Amiens University Hospital, 80054 Amiens, France
2
MP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, France
3
Biochemistry Laboratory, Amiens University Hospital, 80054 Amiens, France
4
Division of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt, 92100 Paris, France
5
Inserm U1018, Team 5, CESP, UVSQ, Paris-Saclay University, 94800 Villejuif, France
6
DRCI, Amiens University Hospital, 80054 Amiens, France
*
Author to whom correspondence should be addressed.
Received: 20 June 2018 / Revised: 17 July 2018 / Accepted: 19 July 2018 / Published: 22 July 2018
(This article belongs to the Special Issue Uremia and Cardiovascular Disease)
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Abstract

Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in-hospital mortality, and poor functional outcomes. Evidence from in vitro studies and in vivo animal experiments suggests that accumulation of uremic toxins may contribute to the pathogenesis of stroke and amplify vascular damage, leading to cognitive disorders and dementia. This review summarizes current evidence on the mechanisms by which uremic toxins may favour the occurrence of cerebrovascular diseases and neurological complications in CKD. View Full-Text
Keywords: stroke; dementia; cognitive disorders; uremic toxins stroke; dementia; cognitive disorders; uremic toxins
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Assem, M.; Lando, M.; Grissi, M.; Kamel, S.; Massy, Z.A.; Chillon, J.-M.; Hénaut, L. The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders. Toxins 2018, 10, 303.

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