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Toxins 2018, 10(7), 303;

The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

Nephrology Department, Amiens University Hospital, 80054 Amiens, France
MP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, France
Biochemistry Laboratory, Amiens University Hospital, 80054 Amiens, France
Division of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt, 92100 Paris, France
Inserm U1018, Team 5, CESP, UVSQ, Paris-Saclay University, 94800 Villejuif, France
DRCI, Amiens University Hospital, 80054 Amiens, France
Author to whom correspondence should be addressed.
Received: 20 June 2018 / Revised: 17 July 2018 / Accepted: 19 July 2018 / Published: 22 July 2018
(This article belongs to the Special Issue Uremia and Cardiovascular Disease)
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Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in-hospital mortality, and poor functional outcomes. Evidence from in vitro studies and in vivo animal experiments suggests that accumulation of uremic toxins may contribute to the pathogenesis of stroke and amplify vascular damage, leading to cognitive disorders and dementia. This review summarizes current evidence on the mechanisms by which uremic toxins may favour the occurrence of cerebrovascular diseases and neurological complications in CKD. View Full-Text
Keywords: stroke; dementia; cognitive disorders; uremic toxins stroke; dementia; cognitive disorders; uremic toxins

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Assem, M.; Lando, M.; Grissi, M.; Kamel, S.; Massy, Z.A.; Chillon, J.-M.; Hénaut, L. The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders. Toxins 2018, 10, 303.

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