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Toxins 2018, 10(7), 295; https://doi.org/10.3390/toxins10070295

Unilateral Botulinum Neurotoxin-A Injection into the Striatum of C57BL/6 Mice Leads to a Different Motor Behavior Compared with Rats

1
Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, D-18057 Rostock, Germany
2
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Macroscopic and Clinical Anatomy, Medical University of Graz, Harrachgasse 21/1, A-8010 Graz, Austria
3
Institute of Medical Genetics, Rostock University Medical Center, Ernst-Heydemann-Strasse 8, D-18057 Rostock, Germany
4
Institute of Neuroscience and Medicine INM-1, Research Center Jülich, D-52425 Jülich, Germany
5
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen, D-52062 Aachen, Germany
6
JARA—Translational Brain Medicine, D-52062 Aachen, Germany
*
Author to whom correspondence should be addressed.
Received: 5 July 2018 / Revised: 13 July 2018 / Accepted: 15 July 2018 / Published: 17 July 2018
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Abstract

Different morphological changes in the caudate-putamen (CPu) of naïve rats and mice were observed after intrastriatal botulinum neurotoxin-A (BoNT-A) injection. For this purpose we here studied various motor behaviors in mice (n = 46) longitudinally up to 9 months after intrastriatal BoNT-A administration as previously reported for rats, and compared both outcomes. Apomorphine- and amphetamine-induced rotational behavior, spontaneous motor behavior, as well as lateralized neglect were studied in mice after the injection of single doses of BoNT-A into the right CPu, comparing them with sham-injected animals. Unilateral intrastriatal injection of BoNT-A in mice induced significantly increased contralateral apomorphine-induced rotations for 1 to 3 months, as well as significantly increased contralateral amphetamine-induced rotations 1 to 9 months after injection. In rats (n = 28), unilateral BoNT-A injection also induced significantly increased contralateral apomorphine-induced rotations 3 months after injection, but did not provoke amphetamine-induced rotations at all. Lateralized sensorimotor integration, forelimb preference, and forelimb stepping were significantly impaired on the left side. The differences in motor behaviors between rats and mice may be caused by different BoNT-A effects on cholinergic and catecholaminergic fibers in rat and mouse striata, interspecies differences in striatal receptor densities, and different connectomes of the basal ganglia. View Full-Text
Keywords: botulinum neurotoxin-A; basal ganglia; interspecies differences in motor behavior; mouse; rat; interneurons botulinum neurotoxin-A; basal ganglia; interspecies differences in motor behavior; mouse; rat; interneurons
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Antipova, V.; Wree, A.; Holzmann, C.; Mann, T.; Palomero-Gallagher, N.; Zilles, K.; Schmitt, O.; Hawlitschka, A. Unilateral Botulinum Neurotoxin-A Injection into the Striatum of C57BL/6 Mice Leads to a Different Motor Behavior Compared with Rats. Toxins 2018, 10, 295.

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