Special Issue "Toxins and Immunology"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 December 2018)
Prof. Jean Marc Cavaillon
Laboratory of Human Histopathology and Animal Models, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
Toxinology and immunology have been closely linked since their respective births, when Behring and Kitasato demonstrated that serotherapy was effective against diphtheria, when Roux and Yersin discovered its dreadful toxin, and when Ramon described the anatoxin that allowed the elaboration of an effective vaccine, and discovered the use of adjuvant to boost the antibody response. Toxins are part of the bacterial arsenal and are responsible for danger of venoms. As a consequence, they need to be targeted by the immune system. Elaboration of neutralizing specific antibodies is part of the immune defense, and the use of serotherapy remains of great help in the case of venom poisoning. Some toxins behave as superantigens and trigger immune cells in a very specific fashion. Toxins activate the inflammasome and the elaboration of endogenous pyrogens that cause fever, a protective mechanism against infection. However, toxins can also induce a cytokine storm with their pathophysiological consequences. Their toxicity can be directed against the immune leukocytes, weakening the immune defense. However, scientists have also diverted its main property to use it as a weapon against tumor cells. Finally, the existence of IgE against toxins may explain their maintenance through evolution despite their side effect in allergy.
The aim of this Special Issue is to offer an overview of the current knowledge in the interaction between toxins and the immune system.
Prof. Jean Marc Cavaillon
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Cell death
- Innate immunity