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Determination of the Role of Microcystis aeruginosa in Toxin Generation Based on Phosphoproteomic Profiles

Beijing Key Laboratory of Fishery Biotechnology, Beijing Fisheries Research Institute, Beijing 100068, China
State key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Toxins 2018, 10(7), 304;
Received: 19 June 2018 / Revised: 12 July 2018 / Accepted: 17 July 2018 / Published: 23 July 2018
(This article belongs to the Special Issue Harmful Algal Bloom Dynamics)
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Microcystis aeruginosa is the most common species responsible for toxic cyanobacterial blooms and is considered a significant contributor to the production of cyanotoxins, particularly the potent liver toxins called microcystins. Numerous studies investigating Microcystis spp. blooms have revealed their deleterious effects in freshwater environments. However, the available knowledge regarding the global phosphoproteomics of M. aeruginosa and their regulatory roles in toxin generation is limited. In this study, we conducted comparative phosphoproteomic profiling of non-toxic and toxin-producing strains of M. aeruginosa. We identified 59 phosphorylation sites in 37 proteins in a non-toxic strain and 26 phosphorylation sites in 18 proteins in a toxin-producing strain. The analysis of protein phosphorylation abundances and functions in redox homeostasis, energy metabolism, light absorption and photosynthesis showed marked differences between the non-toxic and toxin-producing strains of M. aeruginosa, indicating that these processes are strongly related to toxin generation. Moreover, the protein-protein interaction results indicated that BJ0JVG8 can directly interact with the PemK-like toxin protein B0JQN8. Thus, the phosphorylation of B0JQN8 appears to be associated with the regulatory roles of toxins in physiological activity. View Full-Text
Keywords: cyanobacteria; Microcystis aeruginosa; phosphoproteomics; cyanotoxin; microcystin cyanobacteria; Microcystis aeruginosa; phosphoproteomics; cyanotoxin; microcystin

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Qu, J.; Shen, L.; Zhao, M.; Li, W.; Jia, C.; Zhu, H.; Zhang, Q. Determination of the Role of Microcystis aeruginosa in Toxin Generation Based on Phosphoproteomic Profiles. Toxins 2018, 10, 304.

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