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Nutrients, Volume 17, Issue 12

June-2 2025 - 107 articles

Cover Story: Vitamin B3 is a water-soluble vitamin found in various food groups. It is often referred to as niacin, nicotinamide, or nicotinamide riboside (NR). Vitamin B3 is a critical component of the oxidized state of nicotinamide adenine dinucleotide (NAD+), which serves as a redox cofactor in various metabolic reactions and exhibits neuroprotective properties by mitigating oxidative stress. NAD+ levels sharply decline with age, contributing to aging-related diseases. Limited NAD+ bioavailability negatively affects sleep, cognitive function, mitochondrial function, and insulin sensitivity. However, supplementation with vitamin B3 (as NR, nicotinamide mononucleotide, or nicotinamide dinucleotide) may increase NAD+ levels. In this review, we examine the current state of scientific knowledge on the effects of vitamin B3 supplementation on sleep. View this paper
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Articles (107)

  • Article
  • Open Access
6,768 Views
15 Pages
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d-Allulose Ameliorates Fructose-Induced Skeletal Muscle Insulin Resistance via Regulation of Ectopic Lipid Accumulation Independent of Body Weight Changes

  • Shahriar Kamal,
  • Yang Gou,
  • Takamasa Tsuzuki,
  • Linlin Fu,
  • Takako Yamada,
  • Ryoichi Banno and
  • Teruhiko Koike
Nutrients2025, 17(12), 2050;https://doi.org/10.3390/nu17122050

19 June 2025

Background/Objectives: The consumption of fructose-sweetened beverages, especially when combined with a high-fat (HF) diet, substantially contributes to obesity, diabetes, and metabolic dysfunction-associated steatotic liver disease. Ectopic fat accu...

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  • Article
  • Open Access
1 Citations
3,442 Views
18 Pages
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High Dietary Phosphorus Impairs Bone Microarchitecture and Induces Alterations in the LGR4–R-Spondins Axis in Rats with Normal Renal Function

  • Sara Fernández-Villabrille,
  • Francisco Baena-Huerta,
  • Laura Suárez-Fernández,
  • Elena Nefyodova,
  • Paula Calvó,
  • Nerea González-García,
  • Helena Gil-Peña,
  • Carlos Gómez-Alonso,
  • Cristina Alonso-Montes and
  • Manuel Naves-Díaz
  • + 3 authors
Nutrients2025, 17(12), 2049;https://doi.org/10.3390/nu17122049

19 June 2025

Background: The increasing prevalence of processed foods has significantly elevated dietary phosphorus intake globally, posing a risk to skeletal health. Elevated serum phosphate promotes parathyroid hormone (PTH) release, leading to bone resorption...

Full Article
  • Systematic Review
  • Open Access
3 Citations
12,940 Views
27 Pages
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Efficacy of a Low-FODMAP Diet on the Severity of Gastrointestinal Symptoms and Quality of Life in the Treatment of Gastrointestinal Disorders—A Systematic Review of Randomized Controlled Trials

  • Laura Kuźmin,
  • Katarzyna Kubiak and
  • Ewa Lange
Nutrients2025, 17(12), 2045;https://doi.org/10.3390/nu17122045

19 June 2025

Background: A low-FODMAP diet is considered as a potential supportive treatment approach in some gastrointestinal disorders. The aim of this study was to systematically review the literature for randomized controlled trials assessing the efficacy of...

Full Article
  • Article
  • Open Access
2 Citations
1,798 Views
19 Pages
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Modulation of Gut Microbiota by Whole Encapsulated Brown Seaweed (Himanthalia elongata) in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Trial

  • Aroa Lopez-Santamarina,
  • Alejandra Cardelle-Cobas,
  • Alicia del Carmen Mondragon,
  • Alberto Cepeda,
  • Jose A. Rodriguez and
  • Jose Manuel Miranda
Nutrients2025, 17(12), 2047;https://doi.org/10.3390/nu17122047

19 June 2025

Background/Objectives: Brown seaweeds, such as Himanthalia elongata, are a promising source of dietary fiber. However, in vivo evidence regarding the effects of H. elongata intake on the human gut microbiota remains limited. This study aimed to evalu...

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  • Article
  • Open Access
3 Citations
3,378 Views
20 Pages
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Adherence to the EAT-Lancet Diet Among Urban and Rural Latin American Adolescents: Associations with Micronutrient Intake and Ultra-Processed Food Consumption

  • Rulamán Vargas-Quesada,
  • Rafael Monge-Rojas,
  • Sonia Rodríguez-Ramírez,
  • Jacqueline Araneda-Flores,
  • Leandro Teixeira Cacau,
  • Gustavo Cediel,
  • Diego Gaitán-Charry,
  • Tito Pizarro Quevedo,
  • Anna Christina Pinheiro Fernandes and
  • Alicia Rovirosa
  • + 2 authors
Nutrients2025, 17(12), 2048;https://doi.org/10.3390/nu17122048

19 June 2025

Background/Objectives: Adolescents in Latin America are experiencing rising rates of overweight/obesity and non-communicable diseases, while public health nutrition efforts targeting this group remain limited. This study explores adherence to the EAT...

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  • Article
  • Open Access
1 Citations
1,673 Views
15 Pages
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Energy Requirements in the Post-ICU Period: An Exploratory Multicenter Observational Study

  • Marialaura Scarcella,
  • Emidio Scarpellini,
  • Ludovico Abenavoli,
  • Andrea Ceccarelli,
  • Rita Commissari,
  • Riccardo Monti,
  • Jan Tack,
  • Antonella Cotoia and
  • Edoardo De Robertis
Nutrients2025, 17(12), 2046;https://doi.org/10.3390/nu17122046

19 June 2025

Background: There is limited knowledge about nutritional intake and energy needs during the post-intensive care unit (ICU) period and their relationship with clinical outcomes and physical recovery. Aims and Methods: Thus, this observational multicen...

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  • Article
  • Open Access
1,535 Views
23 Pages
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Silkworm Enzyme Hydrolysates Improve Memory in MCI Models via CREB-BDNF Signaling and Enhanced Brain Mitochondrial Function

  • Yoo-Hee Kim,
  • Nguyen Phuong,
  • Nguyen Minh Anh Hoang,
  • Hye-Jin Kim,
  • Moo-Yeol Baik and
  • Young Ho Koh
Nutrients2025, 17(12), 2044;https://doi.org/10.3390/nu17122044

19 June 2025

Background/Objectives: This study investigated whether enzymatic hydrolysis enhances the cognitive benefits of HongJam (steamed mature silkworms) and explored the underlying mechanisms. A marker compound of enzyme-treated HongJam was also identified...

Full Article
  • Article
  • Open Access
1,312 Views
16 Pages
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Quasipaa spinosa-Derived Parvalbumin Attenuates Exercise-Induced Fatigue via Calcium Homeostasis and Oxidative Stress Modulation in Exhaustively Trained Mice

  • Kai Sang,
  • Congfei Lu,
  • Yangfan Zhang and
  • Qi Chen
Nutrients2025, 17(12), 2043;https://doi.org/10.3390/nu17122043

19 June 2025

Background: Quasipaa spinosa crude extract (QSce), a natural source rich in proteins such as parvalbumin (PV), has been traditionally used to promote physical recovery. However, its mechanisms in mitigating exercise-induced fatigue remain unclea...

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  • Article
  • Open Access
10,900 Views
30 Pages
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Effects of 12 Weeks of Chromium, Phyllanthus emblica Fruit Extract, and Shilajit Supplementation on Markers of Cardiometabolic Health, Fitness, and Weight Loss in Men and Women with Risk Factors to Metabolic Syndrome Initiating an Exercise and Diet Intervention: A Randomized Double-Blind, Placebo-Controlled Trial

  • Victoria Martinez,
  • Kay McAngus,
  • Broderick L. Dickerson,
  • Megan Leonard,
  • Elena Chavez,
  • Jisun Chun,
  • Megan Lewis,
  • Dante Xing,
  • Drew E. Gonzalez and
  • Choongsung Yoo
  • + 6 authors
Nutrients2025, 17(12), 2042;https://doi.org/10.3390/nu17122042

19 June 2025

Background: Exercise and nutritional interventions are often recommended to help manage risk related to metabolic syndrome (MetSyn). The co-ingestion of Phyllanthus emblica (PE) with trivalent chromium (Cr) has been purported to improve the bioavaila...

Full Article
  • Article
  • Open Access
1,554 Views
19 Pages
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Overweight, Obesity, and Lifestyle Behaviors in Immigrants and Native Children in Madrid—ASOMAD Study

  • Asmaa Nehari,
  • Alicia Portals-Riomao,
  • Carlos Quesada-González,
  • Augusto G. Zapico,
  • Eva Gesteiro and
  • Marcela González-Gross
Nutrients2025, 17(12), 2041;https://doi.org/10.3390/nu17122041

19 June 2025

Background/Objectives: Overweight and obesity (OW/OB) in immigrant children is a complex multifactorial issue. This work aims to present the OW/OB profile and lifestyle habits of immigrant children and compare them with their native counterparts. Met...

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