Nutrients, Volume 17, Issue 12
2025 June-2 - 107 articles
Cover Story: Vitamin B3 is a water-soluble vitamin found in various food groups. It is often referred to as niacin, nicotinamide, or nicotinamide riboside (NR). Vitamin B3 is a critical component of the oxidized state of nicotinamide adenine dinucleotide (NAD+), which serves as a redox cofactor in various metabolic reactions and exhibits neuroprotective properties by mitigating oxidative stress. NAD+ levels sharply decline with age, contributing to aging-related diseases. Limited NAD+ bioavailability negatively affects sleep, cognitive function, mitochondrial function, and insulin sensitivity. However, supplementation with vitamin B3 (as NR, nicotinamide mononucleotide, or nicotinamide dinucleotide) may increase NAD+ levels. In this review, we examine the current state of scientific knowledge on the effects of vitamin B3 supplementation on sleep. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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