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Nutrients
Special Issues
Relationship between Food Allergy and Human Health
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Relationship between Food Allergy and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 1761

Special Issue Editors

Prof. Dr. Barbara Wróblewska

E-Mail Website
Guest Editor
Institute of Animal Reproduction and Food Research, PAN, Olsztyn, Poland
Interests: food allergy; cow’s milk protein hypersensitivity; mucosal immunity; gut intestinal microbiota; modified diet; food digestion; food technology
Special Issues, Collections and Topics in MDPI journals
Dr. Zlotkowska Dagmara

E-Mail Website
Guest Editor
Institute of Animal Reproduction and Food Research (PAN), Olsztyn, Poland
Interests: mucosal immune system; animal models; Treg; DC; allergy; proteins; flow cytometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The research field of food allergy is experiencing an important development with essential advances in the understanding of the pathophysiology of food allergy, sensitization routes, and the roles that specific immune cells, receptors, and pathways have in the initiation, development, and regulation of food allergies. Novel insights on allergen characterization are not only providing advances in the description of new allergens and their properties, but they are also creating accurate maps of the epitopes recognized by IgE.

Chemical and biochemical characterization and the evaluation of their biological activities go deeper into the relationship between structure and activity of food compounds in terms of their allergenicity. Their gastrointestinal digestibility, bioavailability, benefits and risks for human health are crucial and should be determined.

Your contribution to this Special Issue, in which you are invited to share your findings and insights in the form of research articles, reviews, or short communications, will be a valuable asset and a compelling contribution that will potentially have an important impact on the field of food allergy.

Prof. Dr. Barbara Wróblewska
Dr. Zlotkowska Dagmara
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food allergenicity
  • food intolerance
  • novel food allergens
  • food-derived bioactive compounds
  • host immune modulation
  • immune mechanism of food compounds
  • gut microbiota
  • digestion of food allergens
  • in silico prediction of allergenicity

Published Papers (3 papers)

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Research

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15 pages, 4041 KiB  
Article
Allergenic Shrimp Tropomyosin Distinguishes from a Non-Allergenic Chicken Homolog by Pronounced Intestinal Barrier Disruption and Downstream Th2 Responses in Epithelial and Dendritic Cell (Co)Culture
by Marit Zuurveld, Anna M. Ogrodowczyk, Sara Benedé, Rebecca Czolk, Simona Lucia Bavaro, Stefanie Randow, Lidia H. Markiewicz, Barbara Wróblewska, Elena Molina, Annette Kuehn, Thomas Holzhauser and Linette E. M. Willemsen
Nutrients 2024, 16(8), 1192; https://doi.org/10.3390/nu16081192 - 17 Apr 2024
Viewed by 555
Abstract
Background: Tropomyosins (TM) from vertebrates are generally non-allergenic, while invertebrate homologs are potent pan-allergens. This study aims to compare the risk of sensitization between chicken TM and shrimp TM through affecting the intestinal epithelial barrier integrity and type 2 mucosal immune activation. Methods: [...] Read more.
Background: Tropomyosins (TM) from vertebrates are generally non-allergenic, while invertebrate homologs are potent pan-allergens. This study aims to compare the risk of sensitization between chicken TM and shrimp TM through affecting the intestinal epithelial barrier integrity and type 2 mucosal immune activation. Methods: Epithelial activation and/or barrier effects upon exposure to 2–50 μg/mL chicken TM, shrimp TM or ovalbumin (OVA) as a control allergen, were studied using Caco-2, HT-29MTX, or HT-29 intestinal epithelial cells. Monocyte-derived dendritic cells (moDC), cocultured with HT-29 cells or moDC alone, were exposed to 50 μg/mL chicken TM or shrimp TM. Primed moDC were cocultured with naïve Th cells. Intestinal barrier integrity (TEER), gene expression, cytokine secretion and immune cell phenotypes were determined in these human in vitro models. Results: Shrimp TM, but not chicken TM or OVA exposure, profoundly disrupted intestinal barrier integrity and increased alarmin genes expression in Caco-2 cells. Proinflammatory cytokine secretion in HT-29 cells was only enhanced upon shrimp TM or OVA, but not chicken TM, exposure. Shrimp TM enhanced the maturation of moDC and chemokine secretion in the presence or absence of HT-29 cells, while only in the absence of epithelial cells chicken TM activated moDC. Direct exposure of moDC to shrimp TM increased IL13 and TNFα secretion by Th cells cocultured with these primed moDC, while shrimp TM exposure via HT-29 cells cocultured with moDC sequentially increased IL13 expression and IL4 secretion in Th cells. Conclusions: Shrimp TM, but not chicken TM, disrupted the epithelial barrier while triggering type 2 mucosal immune activation, both of which are key events in allergic sensitization. Full article
(This article belongs to the Special Issue Relationship between Food Allergy and Human Health)
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19 pages, 2288 KiB  
Article
Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects
by Kazuhito Takemoto, Tian Ganlin, Masaki Iji, Takahiro Narukawa, Tomohisa Koyama, Luo Hao and Hiroyuki Watanabe
Nutrients 2024, 16(5), 693; https://doi.org/10.3390/nu16050693 - 29 Feb 2024
Viewed by 738
Abstract
Food allergies are common worldwide and have become a major public health concern; more than 220 million people are estimated to suffer from food allergies worldwide. On the other hand, polyphenols, phenolic substances found in plants, have attracted attention for their health-promoting functions, [...] Read more.
Food allergies are common worldwide and have become a major public health concern; more than 220 million people are estimated to suffer from food allergies worldwide. On the other hand, polyphenols, phenolic substances found in plants, have attracted attention for their health-promoting functions, including their anti-allergic effects. In this study, we examined the potential inhibitory effects of 80% ethanol extracts from 22 different vegetables on the degranulation process in RBL-2H3 cells. Our aim was to identify vegetables that could prevent and treat type I allergic diseases. We found strong inhibition of degranulation by extracts of perilla and chives. Furthermore, we verified the respective efficacy via animal experiments, which revealed that the anaphylactic symptoms caused by ovalbumin (OVA) load were alleviated in OVA allergy model mice that ingested vegetable extracts of perilla and chives. These phenomena were suggested to be caused by induction of suppression in the expression of subunits that constitute the high-affinity IgE receptor, particularly the α-chain of FcεR I. Notably, the anti-allergic effects of vegetables that can be consumed daily are expected to result in the discovery of new anti-immediate allergenic drugs based on the components of these vegetables. Full article
(This article belongs to the Special Issue Relationship between Food Allergy and Human Health)
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Review

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18 pages, 1162 KiB  
Review
Differences in the Course, Diagnosis, and Treatment of Food Allergies Depending on Age—Comparison of Children and Adults
by Julia Kuźniar, Patrycja Kozubek and Krzysztof Gomułka
Nutrients 2024, 16(9), 1317; https://doi.org/10.3390/nu16091317 (registering DOI) - 27 Apr 2024
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Abstract
Food allergy (FA) has become a common global public health issue, with a growing prevalence in the modern world and a significant impact on the lives of patients, their families, and caregivers. It affects every area of life and is associated with elevated [...] Read more.
Food allergy (FA) has become a common global public health issue, with a growing prevalence in the modern world and a significant impact on the lives of patients, their families, and caregivers. It affects every area of life and is associated with elevated costs. Food allergy is an adverse immune reaction that occurs in response to a given food. The symptoms vary from mild to severe and can lead to anaphylaxis. This is why it is important to focus on the factors influencing the occurrence of food allergies, specific diagnostic methods, effective therapies, and especially prevention. Recently, many guidelines have emphasized the impact of introducing specific foods into a child’s diet at an early age in order to prevent food allergies. Childhood allergies vary with age. In infants, the most common allergy is to cow’s milk. Later in life, peanut allergy is more frequently diagnosed. Numerous common childhood allergies can be outgrown by adulthood. Adults can also develop new IgE-mediated FA. The gold standard for diagnosis is the oral provocation test. Skin prick tests, specific IgE measurements, and component-resolved diagnostic techniques are helpful in the diagnosis. Multiple different approaches are being tried as possible treatments, such as immunotherapy or monoclonal antibodies. This article focuses on the prevention and quality of life of allergic patients. This article aims to systematize the latest knowledge and highlight the differences between food allergies in pediatric and adult populations. Full article
(This article belongs to the Special Issue Relationship between Food Allergy and Human Health)
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