Metabolic Health, Lifestyle and Nutritional Interventions in Chronic Inflammatory Diseases

Dear Colleagues,

Autoimmune diseases (ADs) present a significant global health challenge and afflict a considerable proportion of the population, ranging from 5-10%. While a shared genetic predisposition remains a risk factor, other non-hereditary factors also play a critical role in developing these chronic inflammatory conditions. The intricate and fundamental interplay between nutrition and the immune response significantly contributes to the escalating incidence of autoimmune diseases. A person's nutritional status, which is influenced by their food intake and nutrient and bioactive compound ingestion, profoundly impacts the immune system's physical barrier, microbiome, innate immune system, and adaptive immune system.

Metabolic imbalances, such as insulin resistance, gut microbiota alterations, defective antioxidant mechanisms, micronutrient deficiencies, and reduced exposure to physiological germs, are major triggers of immune function deregulation. To foster a better comprehension of the diet–immune system interaction and its impact on autoimmune diseases, it is essential to consider the dietary pattern, metabolic and nutritional status, immune system composition and function, and the resulting epigenetic modification process.

Therefore, this Special Issue endeavors to encourage preclinical and clinical research, observational and meta-analysis studies, and analytical reviews that focus on the role of nutrition in the immune response, autoimmunity, and prospective nutritional strategies to manage autoimmune diseases. It is of utmost importance to take meaningful action and positively impact the lives of those affected by autoimmune diseases.

Dr. Dimitris Tsoukalas
Guest Editor

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• metabolomics
• autoimmune disease
• chronic disease
• chronic inflammatory diseases
• nutritional interventions