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Current Oncology, Volume 29, Issue 10

October 2022 - 104 articles

Cover Story: The combination of an immune checkpoint inhibitor and a multitarget tyrosine kinase inhibitor has become a standard first-line treatment for metastatic renal cell cancer, changing the therapeutic landscape. Along with survival improvement, combination therapy has raised complexity in adverse event handling. Toxicities could be insidious in clinical presentation, and proper attribution to either of the two classes of drugs could be challenging. Key points that clinicians can rely on to achieve an optimal adverse events management are the adherence to immune-related toxicities’ international guidelines, the application of proper expert-defined algorithms, the knowledge sharing within a multidisciplinary dedicated board, and accurate patient information. View this paper
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Articles (104)

  • Article
  • Open Access
11 Citations
3,403 Views
10 Pages

Stereotactic Body Radiation Therapy for Lung and Liver Oligometastases from Breast Cancer: Toxicity Data of a Prospective Non-Randomized Phase II Trial

  • Davide Franceschini,
  • Tiziana Comito,
  • Anna Di Gallo,
  • Veronica Vernier,
  • Marco A. Marzo,
  • Luciana Di Cristina,
  • Beatrice Marini,
  • Lorenzo Lo Faro,
  • Sara Stefanini and
  • Ruggero Spoto
  • + 3 authors

17 October 2022

Aims: We report the mature toxicity data of a phase II non-randomized trial on the use of SBRT for lung and liver oligometastases. Methods: Oligometastatic patients from breast cancer were treated with SBRT for up to five lung and/or liver lesions. I...

  • Article
  • Open Access
19 Citations
3,824 Views
16 Pages

Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution

  • Stefano Bandiera,
  • Luigi Emanuele Noli,
  • Cristiana Griffoni,
  • Giovanni Tosini,
  • Elisa Carretta,
  • Stefano Pasini,
  • Eleonora Pesce,
  • Alfio Damiano Ruinato,
  • Giovanni Barbanti Brodano and
  • Giuseppe Tedesco
  • + 6 authors

17 October 2022

En bloc resection consists in the surgical removal of a vertebral tumor in a single piece with a sufficient margin, to improve survival and reduce recurrence rate. This procedure is technically demanding and correlates with a high complication rate....

  • Article
  • Open Access
9 Citations
3,085 Views
10 Pages

Outcomes of High-Dose Stereotactic Ablative Radiotherapy to All/Multiple Sites for Oligometastatic Renal Cell Cancer Patients

  • Ming-Wei Ma,
  • Hong-Zhen Li,
  • Xian-Shu Gao,
  • Ming-Zhu Liu,
  • Huan Yin,
  • Kai-Wei Yang,
  • Jia-Yan Chen,
  • Xue-Ying Ren and
  • Dian Wang

17 October 2022

Background: Stereotactic ablative body radiotherapy (SABR) is one of the treatment options for oligometastatic renal cell carcinoma (RCC) but is limited by a lack of data to evaluate high-dose SABR to all/multiple sites. Objective: This study retrosp...

  • Review
  • Open Access
30 Citations
5,951 Views
16 Pages

Therapeutic Advances of Rare ALK Fusions in Non-Small Cell Lung Cancer

  • Yan Xiang,
  • Shiyu Zhang,
  • Xiaoxu Fang,
  • Yingying Jiang,
  • Tingwen Fang,
  • Jinwen Liu and
  • Kaihua Lu

16 October 2022

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and is the leading cause of cancer-related death. Despite advances in chemotherapy and immunotherapy, the prognosis for advanced patients remains poor. The dis...

  • Article
  • Open Access
4 Citations
2,799 Views
14 Pages

16 October 2022

Small cell carcinoma of the ovary (SCCO) is a rare type of ovarian cancer with high aggressiveness. The optimal treatment modality remains elusive. This study aims to comprehensively investigate the survival impact of clinical characteristics and tre...

  • Case Report
  • Open Access
3 Citations
3,437 Views
8 Pages

Promising Immune Treatment of Advanced Cutaneous Squamous Cell Carcinoma with Cemiplimab—Real-World Experience in the Global SARS-CoV-2 Pandemic

  • Marta Pabianek,
  • Aleksandra Lesiak,
  • Dariusz Nejc,
  • Łukasz Kuncman,
  • Joanna Narbutt,
  • Małgorzata Skibińska and
  • Magdalena Ciążyńska

16 October 2022

Cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer. The standard curative treatment is surgical resection, but the treatment of locally advanced and metastatic disease apart from radiotherapy is currently ba...

  • Systematic Review
  • Open Access
12 Citations
4,833 Views
15 Pages

15 October 2022

Introduction: Breast cancer is the most common form of cancerous disease worldwide. Its treatment leads to a variety of physiological and psychological side effects. This review investigates the question of how mindfulness-based stress reduction (MBS...

  • Article
  • Open Access
8 Citations
2,950 Views
11 Pages

Health Behavior and Cancer Prevention among Adults with Li-Fraumeni Syndrome and Relatives in Germany—A Cohort Description

  • Juliane Nees,
  • Senta Kiermeier,
  • Farina Struewe,
  • Myriam Keymling,
  • Imad Maatouk,
  • Christian P. Kratz and
  • Sarah Schott

15 October 2022

Li-Fraumeni-syndrome (LFS) is a rare, highly penetrant cancer predisposition syndrome (CPS) caused by pathogenic variants (PVs) in TP53. Physical activity (PA) and a Mediterranean diet lead to cancer reduction or survival benefits and increased quali...

  • Article
  • Open Access
5 Citations
4,013 Views
14 Pages

14 October 2022

Limb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait abnormalities. The proGAIT trial evaluated the effectiveness of an exercise program on gait function a...

  • Brief Report
  • Open Access
10 Citations
3,454 Views
9 Pages

The Geriatric G8 Score Is Associated with Survival Outcomes in Older Patients with Advanced Prostate Cancer in the ADHERE Prospective Study of the Meet-URO Network

  • Giuseppe Luigi Banna,
  • Umberto Basso,
  • Emilio Francesco Giunta,
  • Lucia Fratino,
  • Sara Elena Rebuzzi,
  • Sebastiano Buti,
  • Marco Maruzzo,
  • Ugo De Giorgi,
  • Veronica Murianni and
  • Marika Cinausero
  • + 14 authors

14 October 2022

Introduction: Androgen receptor pathway inhibitors (ARPIs) have been increasingly offered to older patients with prostate cancer (PC). However, prognostic factors relevant to their outcome with ARPIs are still little investigated. Methods and Materia...

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Curr. Oncol. - ISSN 1718-7729