Special Issue "Therapeutic Strategies in Cholangiocarcinoma"
Deadline for manuscript submissions: 30 November 2022 | Viewed by 696
Cholangiocarcinomas (CCA) are heterogeneous highly malignant tumor developed from the biliary tract. It is the second most common primary liver malignancy. Its incidence in Europe and North America has significantly increased without any reason clearly identified. The prognosis is dismal mainly due to tumor aggressiveness, late diagnosis and poor response to current therapies. Three principal forms are described according to their location: intrahepatic, peri-hilar and distal CCA. Interestingly, each subtype has a distinct epidemiology, biology, prognosis, carcinogenesis and molecular alterations responsible of a specific clinical strategy management and with the importance to make an accurate diagnosis. The offer of therapeutic possibility in CCA is wide, ranging from surgery only potentially curative treatment for earlier stage of CCA to targeted therapies depending on molecular alterations. In this special issue about therapeutic strategies of CCA, we will discuss firstly, the importance of the diagnostic process from the point of view of the clinician, the pathologist and the radiologist. In a second step we will deal with the various current therapeutic possibilities. Finally, we will say a word on therapeutic perspectives.
Dr. Nathalie S. Guedj
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