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Current Oncology, Volume 29, Issue 1

2022 January - 35 articles

Cover Story: Although Indigenous Peoples represent a smaller percentage of the population, they tend to experience systematic barriers to equitable care and disproportionately worse health outcomes. To explore Indigenous cancer care supports in Saskatchewan, Canada, an advisory committee with Indigenous patient partners guided a needs assessment study to recommend evidence-based interventions. By conducting key informant interviews and a sharing circle with patients, survivors, and family members, we identified barriers to care and inherent strengths of communities, including kinship, connection to culture, and spirituality. This study provides recommendations that can enhance patient and family experiences and address Indigenous health equity. View this paper
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Articles (35)

  • Article
  • Open Access
7 Citations
3,748 Views
10 Pages

The Benefit of Intraoperative Magnetic Resonance Imaging in Endoscopic and Microscopic Transsphenoidal Resection of Recurrent Pituitary Adenomas

  • Andrej Pala,
  • Andreas Knoll,
  • Max Schneider,
  • Gwendolin Etzrodt-Walter,
  • Georg Karpel-Massler,
  • Christian Rainer Wirtz and
  • Michal Hlavac

17 January 2022

The surgical treatment of recurrent adenomas can be challenging. Intraoperative magnetic resonance imaging (iMRI) can improve the orientation and increase the safe extent of resection. We conducted a quantitative and qualitative retrospective analysi...

  • Article
  • Open Access
3 Citations
3,732 Views
9 Pages

16 January 2022

Metastatic breast cancer (MBC) patient outcomes may vary according to distinct health care payers and different countries. We compared 291 Alberta (AB), Canada and 9429 US patients < 65 with de novo MBC diagnosed from 2010 through 2014. Data were...

  • Case Report
  • Open Access
1 Citations
3,439 Views
6 Pages

15 January 2022

A 79-year-old HIV-negative Caucasian man with a medical history of smoking 20 pack-years (quit 40 years prior), early-stage non-small cell lung cancer status post-lobectomy 13 years earlier at an outside hospital without evidence of recurrence, and b...

  • Review
  • Open Access
17 Citations
6,125 Views
17 Pages

14 January 2022

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, and over half of patients with newly diagnosed GBM are over the age of 65. Management of glioblastoma in older patients includes maximal safe resection followed by either...

  • Article
  • Open Access
4 Citations
3,809 Views
10 Pages

Impact of Body Composition on Postoperative Outcomes in Patients Undergoing Robotic Nipple-Sparing Mastectomy with Immediate Breast Reconstruction

  • Jiae Moon,
  • Jeea Lee,
  • Dong Won Lee,
  • Hye Jung Shin,
  • Sumin Lee,
  • Yhenseung Kang,
  • Na Young Kim and
  • Hyung Seok Park

13 January 2022

Nipple-areolar complex (NAC)-related complications are common during nipple-sparing mastectomy (NSM), with obesity as a risk factor. Although the incidence of NAC-related complications after robotic NSM (RNSM) with immediate breast reconstruction (IB...

  • Systematic Review
  • Open Access
15 Citations
4,290 Views
13 Pages

A Portrait of SARS-CoV-2 Infection in Patients Undergoing Hematopoietic Cell Transplantation: A Systematic Review of the Literature

  • Adrian J. M. Bailey,
  • Aidan M. Kirkham,
  • Madeline Monaghan,
  • Risa Shorr,
  • C. Arianne Buchan,
  • Christopher Bredeson and
  • David S. Allan

13 January 2022

The management of COVID-19 in hematopoietic cell transplant (HCT) recipients represents a special challenge given the variable states of immune dysregulation and altered vaccine efficacy in this population. A systematic search (Ovid Medline and Embas...

  • Systematic Review
  • Open Access
22 Citations
5,229 Views
16 Pages

Safety Profile of Niraparib as Maintenance Therapy for Ovarian Cancer: A Systematic Review and Meta-Analysis

  • Antonia Pagkali,
  • Ioannis Mamais,
  • Adamantios Michalinos and
  • Aris P. Agouridis

12 January 2022

Background: Patients with epithelial ovarian cancer (EOC), treated with niraparib maintenance, present with haematological and gastrointestinal toxicities. Limited data exist on niraparib safety assessment. Objective: To evaluate niraparib safety pro...

  • Article
  • Open Access
4 Citations
3,492 Views
13 Pages

11 January 2022

Objective: To report on clinical outcomes and toxicity in older (age ≥ 70 years) patients with localized pancreatic cancer treated with upfront chemotherapy followed by stereotactic body radiation therapy (SBRT) with or without surgery. Methods: E...

  • Article
  • Open Access
26 Citations
5,545 Views
14 Pages

Lymph Node Dissection Is a Risk Factor for Short-Term Cough after Pulmonary Resection

  • Xiaoli Wu,
  • Hanyang Xing,
  • Ping Chen,
  • Jihua Ma,
  • Xintian Wang,
  • Chengyi Mao,
  • Xiaoying Zhao and
  • Fuqiang Dai

10 January 2022

Cough is a common complication after pulmonary resection. However, the factors associated with cough that develop after pulmonary resection are still controversial. In this study, we used the Simplified Cough Score (SCS) and the Leicester Cough Quest...

  • Article
  • Open Access
2 Citations
3,664 Views
11 Pages

10 January 2022

Background: HER2-positive breast cancer (BC) is a highly aggressive phenotype. The role of the host immune features in predictive response to anti-HER2 therapies and prognosis in BC has already been suggested. We aimed to develop a predictive and pro...

  • Systematic Review
  • Open Access
4 Citations
3,979 Views
16 Pages

Immune-Related Pneumonitis Was Decreased by Addition of Chemotherapy with PD-1/L1 Inhibitors: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials (RCTs)

  • Yi-Xiu Long,
  • Yue Sun,
  • Rui-Zhi Liu,
  • Ming-Yi Zhang,
  • Jing Zhao,
  • Yu-Qing Wang,
  • Yu-Wen Zhou,
  • Ke Cheng,
  • Ye Chen and
  • Ji-Yan Liu
  • + 1 author

9 January 2022

Purpose: Immune-related pneumonitis (IRP) has attracted extensive attention, owing to its increased mortality rate. Conventional chemotherapy (C) has been considered as an immunosuppressive agent and may thus reduce IRP’s risk when used in comb...

  • Systematic Review
  • Open Access
56 Citations
11,589 Views
12 Pages

Uncommon EGFR Compound Mutations in Non-Small Cell Lung Cancer (NSCLC): A Systematic Review of Available Evidence

  • Ilaria Attili,
  • Antonio Passaro,
  • Pasquale Pisapia,
  • Umberto Malapelle and
  • Filippo de Marinis

9 January 2022

Compound epidermal growth factor receptor (EGFR) mutations represent a heterogeneous subgroup of non-small cell lung cancer (NSCLC) patients with uncommon EGFR mutations. We conducted a systematic review to investigate the available data on this pati...

  • Article
  • Open Access
15 Citations
3,619 Views
12 Pages

microRNA Profile Associated with Positive Lymph Node Metastasis in Early-Stage Cervical Cancer

  • Salim Abraham Barquet-Muñoz,
  • Abraham Pedroza-Torres,
  • Carlos Perez-Plasencia,
  • Sarita Montaño,
  • Lenny Gallardo-Alvarado,
  • Delia Pérez-Montiel,
  • Luis Alonso Herrera-Montalvo and
  • David Cantú-de León

8 January 2022

Lymph node metastasis (LNM) is an important prognostic factor in cervical cancer (CC). In early stages, the risk of LNM is approximately 3.7 to 21.7%, and the 5-year overall survival decreases from 80% to 53% when metastatic disease is identified in...

  • Guidelines
  • Open Access
7 Citations
3,275 Views
12 Pages

Neoadjuvant and Adjuvant Systemic Therapy for Newly Diagnosed Stage II–IV Epithelial Ovary, Fallopian Tube, or Primary Peritoneal Carcinoma: A Practice Guideline

  • Hal Hirte,
  • Raymond Poon,
  • Xiaomei Yao,
  • Taymaa May,
  • Josee-Lyne Ethier,
  • Lauri Petz,
  • Jane Speakman and
  • Laurie Elit

8 January 2022

Background: This study aims to provide guidance for the use of neoadjuvant and adjuvant systemic therapy in women with newly diagnosed stage II–IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma. Methods: EMBASE, MEDLINE, and...

  • Article
  • Open Access
6 Citations
2,959 Views
10 Pages

Safety Related to the Timing of Radiotherapy and Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer: A Single Institutional Experience

  • Michael C. Tjong,
  • Malavan Ragulojan,
  • Ian Poon,
  • Alexander V. Louie,
  • Susanna Y. Cheng,
  • Mark Doherty,
  • Liying Zhang,
  • Yee Ung,
  • Patrick Cheung and
  • Parneet K. Cheema

7 January 2022

Background: The safety impact of radiotherapy (RT) timing relative to immune checkpoint inhibitors (ICIs) for advanced non-small-cell lung cancer (NSCLC) is unclear. We investigated if RT within 14 days (Interval 1) and 90 days (Interval 2) of ICI us...

  • Article
  • Open Access
7 Citations
3,974 Views
12 Pages

Small Particle DEBIRI TACE as Salvage Therapy in Patients with Liver Dominant Colorectal Cancer Metastasis: Retrospective Analysis of Safety and Outcomes

  • Nicolas Voizard,
  • Tiffany Ni,
  • Alex Kiss,
  • Robyn Pugash,
  • Michael Jonathon Raphael,
  • Natalie Coburn and
  • Elizabeth David

6 January 2022

The aim of this study was to examine the safety and efficacy of 40 µm and 75 µm calibrated irinotecan-eluting beads (DEBIRI-TACE) for the treatment of colorectal cancer metastases. We conducted a retrospective review of 36 patients with u...

  • Article
  • Open Access
9 Citations
2,903 Views
16 Pages

Impact of Pre-Treatment NLR and Other Hematologic Biomarkers on the Outcomes of Early-Stage Non-Small-Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy

  • Marina Aduquaye,
  • Sheen Dube,
  • Bashir Bashir,
  • Amitava Chowdhury,
  • Naseer Ahmed,
  • Ahmet Leylek,
  • Julian Kim,
  • Pascal Lambert,
  • Oliver Bucher and
  • Shrinivas Rathod
  • + 3 authors

4 January 2022

Introduction: We evaluated the association of pre-treatment immunologic biomarkers on the outcomes of early-stage non-small-cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT). Materials and methods: In this retr...

  • Commentary
  • Open Access
18 Citations
5,800 Views
7 Pages

Equity-Oriented Healthcare: What It Is and Why We Need It in Oncology

  • Tara C. Horrill,
  • Annette J. Browne and
  • Kelli I. Stajduhar

4 January 2022

Alarming differences exist in cancer outcomes for people most impacted by persistent and widening health and social inequities. People who are socially disadvantaged often have higher cancer-related mortality and are diagnosed with advanced cancers m...

  • Article
  • Open Access
5 Citations
3,898 Views
8 Pages

Intraventricular Meningiomas: Clinical-Pathological and Genetic Features of a Monocentric Series

  • Serena Ammendola,
  • Michele Simbolo,
  • Chiara Ciaparrone,
  • Paola Chiara Rizzo,
  • Maria Caffo,
  • Giampietro Pinna,
  • Francesco Sala,
  • Aldo Scarpa and
  • Valeria Barresi

2 January 2022

Intraventricular meningiomas (IVMs) are rare (0.5–5%) and usually low-grade (90% grade I) brain neoplasms. Their recurrence rate is lower than that of extra-axial meningiomas, but their surgical resection can be burdened with life-threatening c...

  • Case Report
  • Open Access
4 Citations
4,633 Views
5 Pages

Is Elevation of Alkaline Phosphatase a Predictive Factor of Response to Alectinib in NSCLC?

  • Walid Shalata,
  • Alexander Yakobson,
  • Rachel Steckbeck,
  • Ashraf Abu Jama,
  • Omar Abu Saleh and
  • Abed Agbarya

31 December 2021

In the following report, we describe a case of alkaline phosphatase (ALP) elevation occurring during treatment with alectinib (Alecensa™), which was administered for anaplastic lymphoma kinase (ALK) mutated metastatic non-small cell lung cancer...

  • Article
  • Open Access
3 Citations
3,228 Views
10 Pages

30 December 2021

It has been reported that 5.1–7.0% of acute pericarditis are carcinomatous pericarditis. Malignant pericardial effusion (MPE) can progress to cardiac tamponade, which is a life-threatening condition. The effectiveness and feasibility of intrape...

  • Article
  • Open Access
4 Citations
2,753 Views
11 Pages

De-Escalating Breast Cancer Surgery: Should We Apply Quality Indicators from Other Jurisdictions in Canada?

  • Hannah Kapur,
  • Leo Chen,
  • Rebecca Warburton,
  • Jin-Si Pao,
  • Carol Dingee,
  • Urve Kuusk,
  • Amy Bazzarelli and
  • Elaine McKevitt

29 December 2021

Quality Indicators (QIs), including the breast-conserving surgery (BCS) rate, were published by the European and American Breast Cancer Societies and this study assesses these in a Canadian population to look for opportunities to de-escalate surgery....

  • Case Report
  • Open Access
1 Citations
2,863 Views
8 Pages

29 December 2021

Uretero-enteric anastomotic strictures (UES) after robot-assisted radical cystectomy (RARC) represent the main cause of post-operative renal dysfunction. The gold standard for treatment of UES is open uretero-ileal reimplantation (UIR), which is ofte...

  • Article
  • Open Access
6 Citations
4,955 Views
12 Pages

Sâkipakâwin: Assessing Indigenous Cancer Supports in Saskatchewan Using a Strength-Based Approach

  • Stephanie Witham,
  • Tracey Carr,
  • Andreea Badea,
  • Meaghan Ryan,
  • Lorena Stringer,
  • Leonzo Barreno and
  • Gary Groot

28 December 2021

Given that the health care system for Indigenous people tends to be complex, fragmented, and multi-jurisdictional, their cancer experiences may be especially difficult. This needs assessment study examined system-level barriers and community strength...

  • Editorial
  • Open Access
1 Citations
2,164 Views
2 Pages

28 December 2021

Malignant lymphoproliferative disorders in the spleen may be primary (usually designated as splenic lymphoma) or secondary (due to progression of nodal or extra nodal lymphoid neoplasms) and represent an underestimated cause of splenomegaly, partiall...

  • Article
  • Open Access
6 Citations
3,764 Views
11 Pages

Specific Bile Microorganisms Caused by Intra-Abdominal Abscess on Pancreaticoduodenectomy Patients: A Retrospective Cohort Study

  • Young-Jen Lin,
  • Te-Wei Ho,
  • Chien-Hui Wu,
  • Ting-Chun Kuo,
  • Ching-Yao Yang,
  • Jin-Ming Wu and
  • Yu-Wen Tien

27 December 2021

We retrospectively collected PD patients with a performance of bile culture between 2007 and 2019 in our institute. As to bile culture, we used a swab to do intraoperative bile cultures after transection of the CBD. IAA was defined as the documental...

  • Perspective
  • Open Access
11 Citations
3,588 Views
8 Pages

27 December 2021

Having a life partner significantly extends survival for most cancer patients. The label given to the partners of cancer patients may, however, influence the health of not just the patients but their partners. “Caregiver” is an increasing...

  • Article
  • Open Access
12 Citations
3,846 Views
17 Pages

The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors

  • Julian Kolorz,
  • Salih Demir,
  • Adrian Gottschlich,
  • Iris Beirith,
  • Matthias Ilmer,
  • Daniel Lüthy,
  • Christoph Walz,
  • Mario M. Dorostkar,
  • Thomas Magg and
  • Michael Berger
  • + 4 authors

26 December 2021

Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 recep...

  • Article
  • Open Access
8 Citations
3,797 Views
9 Pages

24 December 2021

(1) Background: To date, data addressing the antibody response of cancer patients to SARS-CoV-2 vaccines are limited. To our knowledge, this is the first report to evaluate humoral immunity. responses in Canadian cancer patients. (2) Methods: 116 can...

  • Review
  • Open Access
13 Citations
4,322 Views
17 Pages

24 December 2021

Lung cancer ranks first in the incidence and mortality of cancer in the world, of which more than 80% are non-small cell lung cancer (NSCLC). The majority of NSCLC patients are in stage IIIB~IV when they are admitted to hospital and have no opportuni...

  • Review
  • Open Access
14 Citations
5,429 Views
18 Pages

23 December 2021

Immune checkpoint inhibitors have transformed the treatment of metastatic non-small-cell lung cancer, yielding marked improvements in survival and the potential for durable clinical responses. Primary and acquired resistance to current immune checkpo...

  • Article
  • Open Access
13 Citations
4,737 Views
12 Pages

HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer

  • Diana Pádua,
  • Débora Filipa Pinto,
  • Paula Figueira,
  • Carlos Filipe Pereira,
  • Raquel Almeida and
  • Patrícia Mesquita

23 December 2021

Gastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with g...

  • Article
  • Open Access
31 Citations
6,707 Views
13 Pages

22 December 2021

The present study: (a) examined the extent of caregiver burden and psychological wellbeing and (b) tested whether social connectedness moderated the association between caregiver burden and psychological symptoms in caregivers of people with cancer....

  • Article
  • Open Access
5 Citations
4,775 Views
11 Pages

Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Prostate Cancer

  • Darren M. C. Poon,
  • Daisy Lam,
  • Kenneth C. W. Wong,
  • Cheuk-Man Chu,
  • Michael Cheung,
  • Frankie Mo,
  • Joyce Suen,
  • Chi-Fai Ng and
  • Anthony T. C. Chan

22 December 2021

Background: Stereotactic body radiotherapy (SBRT) has potential radiobiologic and economic advantages over conventional fractionated radiotherapy (CFRT) in localized prostate cancer (PC). This study aimed to compare the effects of these two distinct...

  • Article
  • Open Access
4 Citations
3,325 Views
13 Pages

Management Strategies for Older Patients with Low-Risk Early-Stage Breast Cancer: A Physician Survey

  • Mashari Alzahrani,
  • Mark Clemons,
  • Lynn Chang,
  • Lisa Vendermeer,
  • Angel Arnaout,
  • Gail Larocque,
  • Katherine Cole,
  • Tina Hsu,
  • Deanna Saunders and
  • Marie-France Savard

21 December 2021

When managing older patients with lower-risk hormone-receptor-positive (HR+), HER2 negative (HER2−) early-stage breast cancer (EBC), the harms and benefits of adjuvant therapies should be taken into consideration. A survey was conducted among C...

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Curr. Oncol. - ISSN 1718-7729