Current Oncology, Volume 28, Issue 6
December 2021 - 97 articles
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Cover Story: Germline mutations in BRCA genes are a frequent molecular event in the most lethal type of epithelial ovarian cancer, high-grade serous carcinoma (HGSC). To date, little emphasis has been placed on the effects of cancer-causing BRCA1/2 mutations located in different domains of molecules on HGSC prognosis. Therefore, we investigated the correlation between the mutation location within BRCA genes and clinical outcome. After multivariate analysis of the 51-patient cohort, no significant association between the location or type of BRCA1/2 mutation and the PFS or OS was identified. Notably, significant PFS differences between carriers of identical mutations were detected. These outcome dissimilarities reinforce that the clinical course of HGSC is not solely determined by mutation location, suggesting a potential effect of other genetic abnormalities and risk factors. View this paper 
