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Mar. Drugs, Volume 16, Issue 7 (July 2018)
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Cover Story (view full-size image) Pufferfish saxitoxin and tetrodotoxin (TTX) binding protein (PSTBP) is a glycoprotein that we [...] Read more. Pufferfish saxitoxin and tetrodotoxin (TTX) binding protein (PSTBP) is a glycoprotein that we previously detected in the blood plasma of many toxic species of Takifugu pufferfish. Therefore, we proposed that PSTBP is a carrier protein for TTX in pufferfish; however, PSTBP had not yet been found in genera other than Takifugu. In this study, we investigated the presence of PSTBP analogues in the toxic pufferfish other than the genus Takifugu, three species in the genus Arothron and Cheonodon patoca by ultrafiltration method, Western blot analysis and the N-terminal amino acid sequences of the detected glycoproteins. The results demonstrated that PSTBP is not a protein specific to the genus Takifugu, but is distributed over other genera of toxic pufferfish, supporting our hypothesis that PSTBP and its analogues are responsible for the accumulation of TTX in toxic pufferfish. View Paper here.