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Mar. Drugs 2018, 16(7), 246; https://doi.org/10.3390/md16070246

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

1
Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute and MC Slotervaart, 1066 CX Amsterdam, The Netherlands
2
Division of Pharmacology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
3
Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
4
Department of Pharmaceutical Sciences, Faculty of Science, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, 3584 CG Utrecht, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 15 June 2018 / Revised: 15 June 2018 / Accepted: 18 July 2018 / Published: 23 July 2018
(This article belongs to the Collection Marine Compounds and Cancer)
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Abstract

The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification. View Full-Text
Keywords: marine-derived drugs; cancer; bioanalysis; chromatography marine-derived drugs; cancer; bioanalysis; chromatography
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van Andel, L.; Rosing, H.; Schellens, J.H.; Beijnen, J.H. Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment. Mar. Drugs 2018, 16, 246.

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