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Mar. Drugs 2018, 16(7), 218;

The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons

Laboratoire d’Ingénierie des Biomolécules (LIBio), Université de Lorraine, 2 avenue de la Forêt de Haye—TSA 40602, 54518 Vandoeuvre CEDEX, France
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Laboratory for Innovative Microtechnologies and Biomechanics, University of Nebraska-Lincoln, W332 NH, City Campus, Lincoln, NE 68588, USA
Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 10 April 2018 / Revised: 31 May 2018 / Accepted: 13 June 2018 / Published: 25 June 2018
(This article belongs to the Special Issue Marine Drugs and Nanomedicine)
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Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis. View Full-Text
Keywords: nanoliposome; polar lipid; curcumin; transfer; primary cortical neurons nanoliposome; polar lipid; curcumin; transfer; primary cortical neurons

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Hasan, M.; Latifi, S.; Kahn, C.J.; Tamayol, A.; Habibey, R.; Passeri, E.; Linder, M.; Arab-Tehrany, E. The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons. Mar. Drugs 2018, 16, 218.

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