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Marine Drugs
Volume 16
Issue 7
10.3390/md16070229
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Article

Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus

by
Dong-Lan Wu
1,
Hou-Jin Li
2,
Duncan R. Smith
3,
Janejira Jaratsittisin
3,
Xia-Fu-Kai-Ti Xia-Ke-Er
1,
Wen-Zhe Ma
4,
Yong-Wei Guo
1,
Jun Dong
5,
Juan Shen
1,
De-Po Yang
1,* and
Wen-Jian Lan
1,*
1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
3
Institute of Molecular Bioscience, Mahidol University, Bangkok 10700, Thailand
4
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa 519020, Macau, China
5
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(7), 229; https://doi.org/10.3390/md16070229
Submission received: 13 June 2018 / Revised: 27 June 2018 / Accepted: 3 July 2018 / Published: 6 July 2018
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Abstract

In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.
Keywords: marine-derived fungus; Dichotomomyces cejpii; polyketides; alkaloids; antiviral activity; dengue virus marine-derived fungus; Dichotomomyces cejpii; polyketides; alkaloids; antiviral activity; dengue virus

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MDPI and ACS Style

Wu, D.-L.; Li, H.-J.; Smith, D.R.; Jaratsittisin, J.; Xia-Ke-Er, X.-F.-K.-T.; Ma, W.-Z.; Guo, Y.-W.; Dong, J.; Shen, J.; Yang, D.-P.; et al. Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus. Mar. Drugs 2018, 16, 229. https://doi.org/10.3390/md16070229

AMA Style

Wu D-L, Li H-J, Smith DR, Jaratsittisin J, Xia-Ke-Er X-F-K-T, Ma W-Z, Guo Y-W, Dong J, Shen J, Yang D-P, et al. Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus. Marine Drugs. 2018; 16(7):229. https://doi.org/10.3390/md16070229

Chicago/Turabian Style

Wu, Dong-Lan, Hou-Jin Li, Duncan R. Smith, Janejira Jaratsittisin, Xia-Fu-Kai-Ti Xia-Ke-Er, Wen-Zhe Ma, Yong-Wei Guo, Jun Dong, Juan Shen, De-Po Yang, and et al. 2018. "Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus" Marine Drugs 16, no. 7: 229. https://doi.org/10.3390/md16070229

APA Style

Wu, D.-L., Li, H.-J., Smith, D. R., Jaratsittisin, J., Xia-Ke-Er, X.-F.-K.-T., Ma, W.-Z., Guo, Y.-W., Dong, J., Shen, J., Yang, D.-P., & Lan, W.-J. (2018). Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus. Marine Drugs, 16(7), 229. https://doi.org/10.3390/md16070229

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