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Mar. Drugs 2018, 16(7), 222; https://doi.org/10.3390/md16070222

Physicochemical Properties and Biocompatibility Evaluation of Collagen from the Skin of Giant Croaker (Nibea japonica)

1
Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China
2
Hangzhou Meiya Pharmaceutical Co.Ltd, Hangzhou 310011, China
3
Zhejiang Marine Fisheries Reaseach Institution, Zhoushan 316021, China
*
Authors to whom correspondence should be addressed.
Received: 28 May 2018 / Revised: 19 June 2018 / Accepted: 28 June 2018 / Published: 29 June 2018
(This article belongs to the Special Issue Marine Resource and Cosmetics)
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Abstract

Collagen and collagen peptides are widely used as cosmetic ingredients. In the present study, acid-solubilized collagen (ASC) and pepsin-solubilized collagen (PSC) were extracted from giant croaker (Nibea japonica) skin. The proline hydroxylation rates of ASC and PSC were 38.1% and 39.3%. The denaturation temperatures (Td) were approximately 34.5 °C for both ASC and PSC. The results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and fourier transform infrared spetroscopy (FTIR) demonstrated that ASC and PSC were mainly type I collagen. Furthermore, As, Pb and Hg contents in the extracted collagen were lower than the national standards of China. In addition, collagen had good moisture absorption and retention properties when compared to glycerol. The collagen was also not cytotoxic to NIH-3T3 fibroblast cells, indicating that Nibea japonica skin collagen can be utilized in cosmetic applications. View Full-Text
Keywords: Nibea japonica; collagen; characterization; biocompatibility; cosmetics Nibea japonica; collagen; characterization; biocompatibility; cosmetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Tang, Y.; Jin, S.; Li, X.; Li, X.; Hu, X.; Chen, Y.; Huang, F.; Yang, Z.; Yu, F.; Ding, G. Physicochemical Properties and Biocompatibility Evaluation of Collagen from the Skin of Giant Croaker (Nibea japonica). Mar. Drugs 2018, 16, 222.

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