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Marine Drugs, Volume 12, Issue 3

March 2014 - 30 articles

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Articles (30)

  • Review
  • Open Access
79 Citations
14,078 Views
35 Pages

The Challenge of Ecophysiological Biodiversity for Biotechnological Applications of Marine Microalgae

  • Lucia Barra,
  • Raghu Chandrasekaran,
  • Federico Corato and
  • Christophe Brunet

24 March 2014

In this review, we aim to explore the potential of microalgal biodiversity and ecology for biotechnological use. A deeper exploration of the biodiversity richness and ecophysiological properties of microalgae is crucial for enhancing their use for ap...

  • Article
  • Open Access
59 Citations
11,704 Views
14 Pages

Antioxidant and Antimicrobial Potential of the Bifurcaria bifurcata Epiphytic Bacteria

  • André Horta,
  • Susete Pinteus,
  • Celso Alves,
  • Nádia Fino,
  • Joana Silva,
  • Sara Fernandez,
  • Américo Rodrigues and
  • Rui Pedrosa

24 March 2014

Surface-associated marine bacteria are an interesting source of new secondary metabolites. The aim of this study was the isolation and identification of epiphytic bacteria from the marine brown alga, Bifurcaria bifurcata, and the evaluation of the an...

  • Review
  • Open Access
78 Citations
11,243 Views
9 Pages

24 March 2014

Marine bacteria have not been examined as extensively as land bacteria. We screened carotenoids from orange or red pigments-producing marine bacteria belonging to rare or novel species. The new acyclic carotenoids with a C30 aglycone, diapolycopenedi...

  • Article
  • Open Access
18 Citations
9,391 Views
18 Pages

Largazole Pharmacokinetics in Rats by LC-MS/MS

  • Mingming Yu,
  • Lilibeth A. Salvador,
  • Sherwin K. B. Sy,
  • Yufei Tang,
  • Ravi S. P. Singh,
  • Qi-Yin Chen,
  • Yanxia Liu,
  • Jiyong Hong,
  • Hartmut Derendorf and
  • Hendrik Luesch

20 March 2014

A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated. Largazole thiol was extract...

  • Review
  • Open Access
37 Citations
11,970 Views
43 Pages

18 March 2014

Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures and impressive biologica...

  • Communication
  • Open Access
20 Citations
7,948 Views
11 Pages

Ochracenoids A and B, Guaiazulene-Based Analogues from Gorgonian Anthogorgia ochracea Collected from the South China Sea

  • Juan-Juan Zheng,
  • Chang-Lun Shao,
  • Min Chen,
  • Li-She Gan,
  • Yu-Chun Fang,
  • Xu-Hui Wang and
  • Chang-Yun Wang

14 March 2014

Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3–6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucid...

  • Article
  • Open Access
23 Citations
8,349 Views
22 Pages

Potential Polyunsaturated Aldehydes in the Strait of Gibraltar under Two Tidal Regimes

  • Soledad Morillo-García,
  • Nerea Valcárcel-Pérez,
  • Andrés Cózar,
  • María J. Ortega,
  • Diego Macías,
  • Eduardo Ramírez-Romero,
  • Carlos M. García,
  • Fidel Echevarría and
  • Ana Bartual

13 March 2014

Diatoms, a major component of the large-sized phytoplankton, are able to produce and release polyunsaturated aldehydes after cell disruption (potential PUAs or pPUA). These organisms are dominant in the large phytoplankton fraction (>10 µm) in the...

  • Article
  • Open Access
14 Citations
15,874 Views
11 Pages

13 March 2014

Sea angels, Clione limacina and Paedoclione doliiformis, are small, floating sea slugs belonging to Gastropoda, and their gonads are a bright orange-red color. Sea angels feed exclusively on a small herbivorous sea snail, Limacina helicina. Carotenoi...

  • Review
  • Open Access
5 Citations
8,479 Views
24 Pages

13 March 2014

Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteri...

  • Article
  • Open Access
37 Citations
10,675 Views
17 Pages

Construction and Characterization of an Escherichia coli Mutant Producing Kdo2-Lipid A

  • Jianli Wang,
  • Wenjian Ma,
  • Zhou Wang,
  • Ye Li and
  • Xiaoyuan Wang

13 March 2014

3-deoxy-d-manno-oct-2-ulosonic acid (Kdo)2-lipid A is the conserved structure domain of lipopolysaccharide found in most Gram-negative bacteria, and it is believed to stimulate the innate immune system through the TLR4/MD2 complex. Therefore, Kdo2-l...

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Mar. Drugs - ISSN 1660-3397