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Chemistry and Biology of Bengamides and Bengazoles, Bioactive Natural Products from Jaspis Sponges

Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Campus de Teatinos s/n., Málaga 29071, Spain
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(3), 1580-1622;
Received: 30 December 2013 / Revised: 24 January 2014 / Accepted: 25 February 2014 / Published: 18 March 2014
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Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures and impressive biological profiles, including antitumor, antibiotic and anthelmintic properties. As a consequence, intense research activity has been devoted to these compounds from both chemical and biological standpoints. This review describes in detail the research into these classes of natural products and the benefits they offer in chemistry and biology. View Full-Text
Keywords: bengamides; bengazoles; antitumor; analogues; total synthesis bengamides; bengazoles; antitumor; analogues; total synthesis

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García-Ruiz, C.; Sarabia, F. Chemistry and Biology of Bengamides and Bengazoles, Bioactive Natural Products from Jaspis Sponges. Mar. Drugs 2014, 12, 1580-1622.

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