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Molecules, Volume 29, Issue 5

March-1 2024 - 268 articles

Cover Story: NK cells are highly valued in immunotherapy for their ability to rapidly kill tumor cells as well as their favorable safety profile. Their cytotoxic function is governed by a complex interplay of activating and inhibiting receptors, presenting a plethora of antigens for functional modulation via antibodies. Effective NK cell activation is attainable through the stimulation of activating receptors such as CD16, or by blocking inhibitory checkpoint molecules like TIGIT. Coupled with a binding domain for tumor-associated proteins such as B7-H3, these components can orchestrate the formation of an immunological synapse. The novel trispecific 2+1 common light chain NK cell engager B7-H3xCD16xTIGIT combines these three functionalities, facilitating potent apoptosis induction of cancer cells. View this paper
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Articles (268)

  • Article
  • Open Access
3 Citations
1,776 Views
15 Pages

Biodegradable Metal Complex-Gated Organosilica for Dually Enhanced Chemodynamic Therapy through GSH Depletions and NIR Light-Triggered Photothermal Effects

  • Lin Kong,
  • Jian Li,
  • Yunxiu Zhang,
  • Jian Wang,
  • Ke Liang,
  • Xiaokuang Xue,
  • Tiejin Chen,
  • Yongliang Hao,
  • Haohui Ren and
  • Pengfei Wang
  • + 1 author

Hollow silica spheres have been widely studied for drug delivery because of their excellent biosecurity and high porosity. However, difficulties with degradation in the tumor microenvironment (TME) and premature leaking during drug delivery limit the...

  • Article
  • Open Access
4 Citations
2,186 Views
28 Pages

Various functional groups have been considered as acceptors for halogen bonds, but the oxime functionality has received very little attention in this context. In this study, we focus on the analysis of the hydrogen and halogen bond preferences observ...

  • Article
  • Open Access
5 Citations
1,794 Views
18 Pages

Flame Retardancy of Short Flax Fibers Modified by Radiation-Induced Grafting of Phosphonated Monomers: Comparison between Pre- and Simultaneous Irradiation Grafting

  • Clément Brendlé,
  • Roland El Hage,
  • Jean-Louis Clément,
  • Sophie Rouif,
  • Rodolphe Sonnier and
  • Belkacem Otazaghine

Short flax fibers have been modified by radiation-induced grafting using methacrylate monomers containing phosphorus to give them a flame-retardant character. Two methodologies, namely pre-irradiation and simultaneous irradiation grafting, were exami...

  • Article
  • Open Access
2,166 Views
16 Pages

Effect of Copper Antifouling Paint on Marine Degradation of Polypropylene: Uneven Distribution of Microdebris between Nagasaki Port and Goto Island, Japan

  • Hisayuki Nakatani,
  • Kaito Yamashiro,
  • Taishi Uchiyama,
  • Suguru Motokucho,
  • Anh Thi Ngoc Dao,
  • Hee-Jin Kim,
  • Mitsuharu Yagi and
  • Yusaku Kyozuka

Microplastics (MP) encompass not only plastic products but also paint particles. Marine microdebris, including MP, was retrieved from five sampling stations spanning Nagasaki-Goto island and was classified into six types, primarily consisting of MP (...

  • Article
  • Open Access
2 Citations
2,621 Views
13 Pages

The combustion behavior of various propellant samples, including double-base propellants, pressed nitramine powders, and modified double-base propellants containing nitramine, was examined using OH-PLIF technology. The combustion process took place w...

  • Review
  • Open Access
47 Citations
9,790 Views
19 Pages

Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedde...

  • Article
  • Open Access
3 Citations
2,135 Views
14 Pages

Bopyeo-tang (BPT) is composed of six medicinal herbs (Morus alba L., Rehmannia glutinosa (Gaertn.) DC., Panax ginseng C.A.Mey., Aster tataricus L.f., Astragalus propinquus Schischkin, and Schisandra chinensis (Turcz.) Baill.) and has been used for th...

  • Review
  • Open Access
11 Citations
3,929 Views
12 Pages

Nowadays, antibiotics are widely used, increasing the risk of contamination of the water body and further threatening human health. The traditional water treatment process is less efficient in degrading antibiotics, and the advanced oxidation process...

  • Review
  • Open Access
37 Citations
7,909 Views
17 Pages

Recent Advances in Fluorescent Probes for Cancer Biomarker Detection

  • Mingce Tian,
  • Riliga Wu,
  • Caihong Xiang,
  • Guangle Niu and
  • Weijiang Guan

Many important biological species have been identified as cancer biomarkers and are gradually becoming reliable targets for early diagnosis and late therapeutic evaluation of cancer. However, accurate quantitative detection of cancer biomarkers remai...

  • Article
  • Open Access
15 Citations
2,859 Views
15 Pages

Construction of Bi2WO6/g-C3N4 Z-Scheme Heterojunction and Its Enhanced Photocatalytic Degradation of Tetracycline with Persulfate under Solar Light

  • Yukun Li,
  • Haiyang Zhang,
  • Dan Zhang,
  • Sen Yao,
  • Shuying Dong,
  • Qishi Chen,
  • Fengjuan Fan,
  • Hongyuan Jia and
  • Mingjia Dong

Z-scheme heterojunction Bi2WO6/g-C3N4 was obtained by a novel hydrothermal process; its photocatalysis–persulfate (PDS) activation for tetracycline (TC) removal was explored under solar light (SL). The structure and photoelectrochemistry behavi...

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Molecules - ISSN 1420-3049