Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
4.2
Journals
Molecules
Special Issues
Terpenes, Steroids and Their Derivatives (2nd Edition) 
molecules-logo
Submit to Molecules Review for Molecules Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Terpenes, Steroids and Their Derivatives (2nd Edition) 

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 5986

Special Issue Editors

Prof. Dr. Pavel B. Drasar

E-Mail Website
Guest Editor
Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Technicka 5, CZ 166 28 Prague, Czech Republic
Interests: natural product chemistry; synthesis of heterocycles; non-hormonally active steroids; terpenes; supramolecular systems with chiral natural products; fluorescent labelling
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Vladimir A. Khripach

E-Mail Website
Guest Editor
The Institute of Bioorganic Chemistry, The National Academy of Sciences of Belarus, 5/2 Academician V.F.Kuprevich Street, BY-220141 Minsk, Belarus
Interests: steroids; natural product heterocyclic and pesticide chemistry; synthesis, bioactivity, and practical application of natural bioregulators and their analogs in agriculture and medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Terpenes and steroids, including their derivatives and general isoprenoids, as natural secondary metabolites, play stable and growing roles in human and veterinary medicine, supramolecular chemistry, food and cosmetic R&D, industry, and an increasing number of other fields. Their importance is based, i.e., on the fact that they are mostly bound to renewable sources, which, in fact, makes them valuable within a circular economy. Terpenes and steroids are also origins of stereochemistry, regioselectivity, chirality, and many other features as well as disciplines within science, development, and industry on a scale that is indispensable.

This Special Issue, which is a sequel, aims to further underline current developments in all fields that are connected to terpene and steroid research as well as utilization and will present a sequel to the successful Special Issues of Molecules edited by Vladimir Khripach and Pavel Drašar.

Prof. Dr. Pavel B. Drasar
Prof. Dr. Vladimir A. Khripach
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • terpene and steroid chemistry, biochemistry, repurposing, and practical utilization
  • terpene and steroid derivative synthesis
  • isolation and analysis of terpenes and steroids
  • terpene and steroid medicinal as well as cosmetic utilization
  • fluorescent labeling, bio-imaging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

22 pages, 2106 KiB  
Article
Simultaneous Quantification of Bioactive Triterpene Saponins Calenduloside E and Chikusetsusaponin IVa in Different Plant Parts of Ten Amaranthaceae Species by UPLC-ESI-MS/MS Method
by Karolina Grabowska, Paweł Żmudzki, Agnieszka Galanty and Irma Podolak
Molecules 2025, 30(5), 1088; https://doi.org/10.3390/molecules30051088 - 27 Feb 2025
Cited by 1 | Viewed by 358
Abstract
Calenduloside E (CE) and chikusetsusaponin IVa (ChIVa) are triterpene saponins with multidirectional bioactivity. In this study, the contents of CE and ChIVa were determined in the roots, stems, leaves, and fruits of ten wild-growing species of Amaranthaceae. To achieve optimal extraction conditions for [...] Read more.
Calenduloside E (CE) and chikusetsusaponin IVa (ChIVa) are triterpene saponins with multidirectional bioactivity. In this study, the contents of CE and ChIVa were determined in the roots, stems, leaves, and fruits of ten wild-growing species of Amaranthaceae. To achieve optimal extraction conditions for both saponins, maceration, shaking-assisted maceration, and ultrasound-assisted and heat reflux extraction were compared. A sensitive, specific, and rapid UPLC-MS/MS method was developed and validated for the simultaneous quantification of CE and ChIVa. The results showed that CE and ChIVa coexisted in most of the species analyzed, except for Ch. hybridum. For the first time, the presence of CE and ChIVa was noted in L. polysperma, A. patula, B. bonus-henricus, O. rubra, and O. glauca. Of the species analyzed, the highest ChIVa content was found in the fruit of A. sagittata (13.15 mg/g dw), L. polysperma (12.20 mg/g dw), and Ch. album (10.0 mg/g dw), and in the fruit and roots of Ch. strictum (5.52 and 7.77 mg/g dw, respectively). The highest amount of CE was determined in the fruit of A. sagittata (7.84 mg/g dw) and Ch. strictum (6.54 mg/g dw). These saponin-abundant plant parts of Amaranthaceae spp. may be considered convenient sources of these bioactive saponins. Full article
(This article belongs to the Special Issue Terpenes, Steroids and Their Derivatives (2nd Edition) )
►▼ Show Figures

Graphical abstract

18 pages, 1997 KiB  
Article
Bis-Iridoid Glycosides and Triterpenoids from Kolkwitzia amabilis and Their Potential as Inhibitors of ACC1 and ACL
by Jiang Wan, Ze-Yu Zhao, Can Wang, Chun-Xiao Jiang, Ying-Peng Tong, Yi Zang, Yeun-Mun Choo, Jia Li and Jin-Feng Hu
Molecules 2024, 29(24), 5980; https://doi.org/10.3390/molecules29245980 - 18 Dec 2024
Cited by 3 | Viewed by 709
Abstract
A comprehensive phytochemical investigation of the twigs/leaves and flower buds of Kolkwitzia amabilis, a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (1–4 and 7– [...] Read more.
A comprehensive phytochemical investigation of the twigs/leaves and flower buds of Kolkwitzia amabilis, a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (1–4 and 7–13), 20 triterpenoids (5, 6, and 14–31), and 8 phenylpropanoids (32–39). Among these, amabiliosides A (1) and B (2) represent previously undescribed bis-iridoid glycosides, while amabiliosides C (3) and D (4) feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro-β-carboline-5-carboxylic acid moiety. Amabiliacids A (5) and B (6) are 24-nor-ursane-type triterpenoids characterized by an uncommon ∆11,13(18) transannular double bond. Their chemical structures and absolute configurations were elucidated through spectroscopic data and electronic circular dichroism analyses. Compound 2 exhibited a moderate inhibitory effect against acetyl CoA carboxylase 1 (ACC1), with an IC50 value of 9.6 μM. Lonicejaposide C (8), 3β-O-trans-caffeoyl-olean-12-en-28-oic acid (29), and (23E)-coumaroylhederagenin (31) showed notable inhibitory effects on ATP-citrate lyase (ACL), with IC50 values of 3.6, 1.6, and 4.7 μM, respectively. Additionally, 3β-acetyl-ursolic acid (17) demonstrated dual inhibitory activity against both ACC1 and ACL, with IC50 values of 10.3 and 2.0 μM, respectively. The interactions of the active compounds with ACC1 and ACL enzymes were examined through molecular docking studies. From a chemotaxonomic perspective, the isolation of bis-iridoid glycosides in this study may aid in clarifying the taxonomic relationship between the genera Kolkwitzia and Lonicera within the Caprifoliaceae family. These findings highlight the importance of conserving plant species with unique and diverse secondary metabolites, which could serve as potential sources of new therapeutic agents for treating ACC1/ACL-associated diseases. Full article
(This article belongs to the Special Issue Terpenes, Steroids and Their Derivatives (2nd Edition) )
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

19 pages, 1003 KiB  
Review
Therapeutic Potential of Fungal Terpenes and Terpenoids: Application in Skin Diseases
by Monika Trepa, Katarzyna Sułkowska-Ziaja, Katarzyna Kała and Bożena Muszyńska
Molecules 2024, 29(5), 1183; https://doi.org/10.3390/molecules29051183 - 6 Mar 2024
Cited by 14 | Viewed by 4252
Abstract
Terpenes and their derivatives comprise a diverse group of natural compounds with versatile medicinal properties. This article elucidates the general characteristics of fungal terpenes and terpenoids, encompassing their structure and biogenesis. The focal point of this work involves a comprehensive overview of these [...] Read more.
Terpenes and their derivatives comprise a diverse group of natural compounds with versatile medicinal properties. This article elucidates the general characteristics of fungal terpenes and terpenoids, encompassing their structure and biogenesis. The focal point of this work involves a comprehensive overview of these compounds, highlighting their therapeutic properties, mechanisms of action, and potential applications in treating specific skin conditions. Numerous isolated terpenes and terpenoids have demonstrated noteworthy anti-inflammatory and anti-microbial effects, rivalling or surpassing the efficacy of currently employed treatments for inflammation or skin infections. Due to their well-documented antioxidant and anti-cancer attributes, these compounds exhibit promise in both preventing and treating skin cancer. Terpenes and terpenoids sourced from fungi display the capability to inhibit tyrosinase, suggesting potential applications in addressing skin pigmentation disorders and cancers linked to melanogenesis dysfunctions. This paper further disseminates the findings of clinical and in vivo research on fungal terpenes and terpenoids conducted thus far. Full article
(This article belongs to the Special Issue Terpenes, Steroids and Their Derivatives (2nd Edition) )
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop