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Molecules, Volume 29, Issue 6

March-2 2024 - 227 articles

Cover Story: Egg yolk proteins are better substrates for pepsin, trypsin and proteinase K compared to those from egg white. On the other hand, pepsin and proteinase K are more efficient, compared to trypsin, in breaking the intramolecular peptide bonds of the high-molecular-weight egg proteins. The enzyme-assisted hydrolysis allows for a significant increase in antioxidant activity, suggesting that many bioactive peptides are encrypted in an inactive form in the parent egg proteins. The hydrolysates obtained with proteinase K exhibit the highest antioxidant activity and the lowest residual IgE-binding capacity. The bioinformatics tools revealed that proteinase K is able to break the integrity of the main linear IgE-binding epitopes from ovalbumin and ovomucoid. Proteinase K is a promising tool for modulating the intrinsic properties of egg proteins. View this paper
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Articles (227)

  • Article
  • Open Access
4 Citations
3,455 Views
13 Pages

Construction of Uniform LiF Coating Layers for Stable High-Voltage LiCoO2 Cathodes in Lithium-Ion Batteries

  • Ziyang Xiao,
  • Xiangbing Zhu,
  • Shuguang Wang,
  • Yanhong Shi,
  • Huimin Zhang,
  • Baobin Xu,
  • Changfeng Zhao and
  • Yan Zhao

21 March 2024

Stabilizing LiCoO2 (LCO) at 4.5 V rather than the common 4.2 V is important for the high specific capacity. In this study, we developed a simple and efficient way to improve the stability of LiCoO2 at high voltages. After a simple sol–gel metho...

  • Article
  • Open Access
15 Citations
4,719 Views
17 Pages

A Study on the Adsorption of Rhodamine B onto Adsorbents Prepared from Low-Carbon Fossils: Kinetic, Isotherm, and Thermodynamic Analyses

  • Aleksandra Bazan-Wozniak,
  • Aleksandra Jędrzejczak,
  • Robert Wolski,
  • Sławomir Kaczmarek,
  • Agnieszka Nosal-Wiercińska,
  • Judyta Cielecka-Piontek,
  • Sultan Yagmur-Kabas and
  • Robert Pietrzak

21 March 2024

The aim of this study was to obtain a series of activated carbon samples by the chemical activation of low-rank coal. The precursor was impregnated with a NaOH solution. Activated carbons were characterized by determining their textural parameters an...

  • Article
  • Open Access
1 Citations
2,112 Views
16 Pages

Antibacterial Activities and Underlying Mechanisms of the Compound SYAUP-491 against Xanthomonas oryzae pv. oryzae

  • Lina Li,
  • Yuxin Wang,
  • He Liu,
  • Wei Liu,
  • Xinchen Zhang,
  • Mengnan An,
  • Miao Yu,
  • Yuanhua Wu,
  • Xinghai Li and
  • Jianzhong Wang

21 March 2024

SYAUP-491 is a novel alkyl sulfonamide. In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent...

  • Article
  • Open Access
1 Citations
2,045 Views
14 Pages

21 March 2024

Graphdiyne (GDY) is considered a very attractive support for metal nanocatalysts due to its unique structure and superior properties. The metal–GDY interaction can significantly affect the performance of catalysts. Herein, GDY nanotubes abundan...

  • Review
  • Open Access
6 Citations
3,386 Views
14 Pages

21 March 2024

Close to 19% of the world population suffers from anxiety. Current medications for this chronic mental disorder have improved treatment over the last half century or more, but the newer anxiolytics have proved disappointing, and enormous challenges r...

  • Review
  • Open Access
4 Citations
6,832 Views
42 Pages

Asymmetric α-Fluoroalkyl-α-Amino Acids: Recent Advances in Their Synthesis and Applications

  • Nathan Picois,
  • Yazid Boutahri,
  • Pierre Milbeo,
  • Chiara Zanato,
  • Nathalie Lensen,
  • Grégory Chaume and
  • Thierry Brigaud

21 March 2024

Due to the specific properties provided by fluorine atoms to biomolecules, amino acids with fluorinated side chains are of great interest for medicinal chemistry and chemical biology. Among them, α-fluoroalkyl-α-amino acids constitute a u...

  • Review
  • Open Access
2 Citations
3,463 Views
47 Pages

21 March 2024

The impact of organometallic chemistry on the terpene field only really blossomed in the 1960s and 1970s with the realisation that carbon–carbon bond formation under mild conditions could be achieved by using nickel or iron carbonyls as synthet...

  • Article
  • Open Access
3 Citations
3,145 Views
30 Pages

Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines

  • Lijie Zhu,
  • Binzhuo Liu,
  • Feng Jin,
  • Weilong Cao,
  • Guangzhao Xu,
  • Xinwei Zhang,
  • Peng Peng,
  • Dingding Gao,
  • Bin Wang and
  • Kairui Feng

21 March 2024

A series of novel 4-Hydroxyquinazoline derivatives were designed and synthesized to enhance sensitivity in primary PARPi-resistant cells. Among them, the compound B1 has been found to have superior cytotoxicity in primary PARPi-resistant HCT-15 and H...

  • Article
  • Open Access
4 Citations
2,693 Views
16 Pages

Design, Synthesis, and Biological Evaluation of Novel Coumarin Analogs Targeted against SARS-CoV-2

  • Kirti Sharma,
  • Manjinder Singh,
  • Pratibha Sharma,
  • Sumesh C. Sharma,
  • Somdutt Mujwar,
  • Mohit Kapoor,
  • Krishna Kumar Mishra and
  • Tanveer A. Wani

21 March 2024

SARS-CoV, an RNA virus, is contagious and displays a remarkable degree of adaptability, resulting in intricate disease presentations marked by frequent genetic mutations that can ultimately give rise to drug resistance. Targeting its viral replicatio...

  • Article
  • Open Access
1 Citations
3,102 Views
18 Pages

21 March 2024

Design of amyloid β-protein (Aβ) inhibitors is considered an effective strategy for the prevention and treatment of Alzheimer’s disease (AD). However, the limited blood–brain barrier (BBB) penetration and poor Aβ-targeting...

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Molecules - ISSN 1420-3049