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Molecules, Volume 29, Issue 17

September-1 2024 - 301 articles

Cover Story: The increase in drug resistance in bacteria is an urgent global health issue. Amphiphilic α-hydrazido acid derivatives are structurally simple mimics of antimicrobial peptides. The mechanism of membrane permeabilization at subtoxic concentrations is due to a rapid insertion, followed by an accumulation into the bilayer that increases membrane fluidity and permeability without major structural damages. When evaluated in combination with conventional antibiotics, they proved to be synergistic with tetracycline against sensitive Staphylococcus aureus and Escherichia coli, as well as with ciprofloxacin and colistin against resistant strains. In other cases, additive effects were observed, with a remarkable increase in the activity of conventional antibiotics for combinations with ciprofloxacin toward susceptible S. aureus and methicillin toward MRSA. View this paper
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Articles (301)

  • Article
  • Open Access
6 Citations
3,749 Views
17 Pages

MSC Exosomes Containing Valproic Acid Promote Wound Healing by Modulating Inflammation and Angiogenesis

  • Yujie Mu,
  • Xiaona Zhang,
  • Linfeng Zhang,
  • Ruting Luo,
  • Yin Zhang and
  • Min Wang

9 September 2024

Purpose: Chronic wounds that are difficult to heal pose a major challenge for clinicians and researchers. Currently, common treatment methods focus on isolating the wound from the outside world, relying on the tissue at the wound site to grow and hea...

  • Review
  • Open Access
18 Citations
7,374 Views
40 Pages

Promising Therapeutic Strategies for Hematologic Malignancies: Innovations and Potential

  • Jan Jakub Lica,
  • Bhaskar Pradhan,
  • Kawthar Safi,
  • Joanna Jakóbkiewicz-Banecka and
  • Andrzej Hellmann

9 September 2024

In this review we explore innovative approaches in the treatment of hematologic cancers by combining various therapeutic modalities. We discuss the synergistic potential of combining inhibitors targeting different cellular pathways with immunotherapi...

  • Article
  • Open Access
6 Citations
2,631 Views
14 Pages

The Role of Indigenous Yeasts in Shaping the Chemical and Sensory Profiles of Wine: Effects of Different Strains and Varieties

  • Xin-Ke Zhang,
  • Pei-Tong Liu,
  • Xiao-Wei Zheng,
  • Ze-Fu Li,
  • Jian-Ping Sun,
  • Jia-Shuo Fan,
  • Dong-Qing Ye,
  • De-Mei Li,
  • Hai-Qi Wang and
  • Qing-Quan Yu
  • + 1 author

9 September 2024

The microbial terroir is an indispensable part of the terroir panorama, and can improve wine quality with special characteristics. In this study, eight autochthonous yeasts (Saccharomyces cerevisiae), selected in Huailai country, China, were trailed...

  • Article
  • Open Access
1,372 Views
15 Pages

The Effect of the Lysine Acetylation Modification of ClpP on the Virulence of Vibrio alginolyticus

  • Shi Wang,
  • Yingying Jiang,
  • Weijie Zhang,
  • Yingzhu Wei,
  • Xing Xiao,
  • Zhiqing Wei,
  • Xiaoxin Wen,
  • Yuhang Dong,
  • Jichang Jian and
  • Na Wang
  • + 1 author

9 September 2024

Acetylation modification has become one of the most popular topics in protein post-translational modification (PTM) research and plays an important role in bacterial virulence. A previous study indicated that the virulence-associated caseinolytic pro...

  • Article
  • Open Access
1 Citations
1,874 Views
20 Pages

Polyamine Derived Photosensitizer: A Novel Approach for Photodynamic Therapy of Cancer

  • Hao Deng,
  • Ke Xie,
  • Liling Hu,
  • Xiaowen Liu,
  • Qingyun Li,
  • Donghui Xie,
  • Fengyi Xiang,
  • Wei Liu,
  • Weihong Zheng and
  • Shuzhang Xiao
  • + 2 authors

9 September 2024

Polyamines play a pivotal role in cancer cell proliferation. The excessive polyamine requirement of these malignancies is satisfied through heightened biosynthesis and augmented extracellular uptake via the polyamine transport system (PTS) present on...

  • Article
  • Open Access
3 Citations
2,567 Views
12 Pages

9 September 2024

The reverse-mode smart windows, which usually fabricated by polymer stabilized liquid crystal (PSLC), are more practical for scenarios where high transparency is a priority for most of the time. However, the polymer stabilized cholesteric liquid crys...

  • Article
  • Open Access
2 Citations
2,641 Views
23 Pages

Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism of Protopanaxadiol Triphenylphosphate Derivative in Non-Small-Cell Lung Cancer

  • Liu Han,
  • Xingbo Bian,
  • Xiangyu Ma,
  • Ting Ren,
  • Yawei Li,
  • Lijing Huang,
  • Zebo Tang,
  • Liancong Gao,
  • Sheng Chang and
  • Xin Sun

9 September 2024

The objective of this study was to enhance the membrane permeability and anticancer effectiveness of (20S)-protopanaxadiol (PPD) by introducing triphenylphosphonium into the OH group at the C-3 site. This study shows that the anti-proliferation activ...

  • Article
  • Open Access
2 Citations
1,804 Views
18 Pages

9 September 2024

The influence of solvent properties on ion generation by swab spray ionization was investigated. The ability of a variety of solvents of different relative permittivity, surface tension, and viscosity to form a stable and reproducible electrospray wa...

  • Article
  • Open Access
1 Citations
1,881 Views
23 Pages

Synthesis and Anticancer Activity of 3,4-Diaryl-1,2-dihydro- and 1,2,3,4-Tetrahydroquinolines

  • Santosh Rajput,
  • Valerio Falasca,
  • Mohan Bhadbhade,
  • David StC Black and
  • Naresh Kumar

9 September 2024

Tetrahydroquinolines are key structures in a variety of natural products with diverse pharmacological utilities and other applications. A series of 3,4-diaryl-5,7-dimethoxy-1,2,3,4-tetrahydroquinolines were synthesized in good yield by reacting 3-ary...

  • Article
  • Open Access
1 Citations
1,425 Views
10 Pages

9 September 2024

In this paper, iron phthalocyanine nanowires on a nickel foam (FePc@NF) composite catalyst were prepared by a facile solvothermal approach. The catalyst showed good electrochemical oxygen evolution performance. In 1.0 M KOH electrolyte, 289 mV low ov...

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Molecules - ISSN 1420-3049