Design, Synthesis and Evaluation of Small Molecule Drugs
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (1 March 2025) | Viewed by 5755

Special Issue Editors
Interests: drug design; synthesis and characterization of molecules; medicinal chemistry; serotoninergic ligands; NCX isoform modulators
Special Issue Information
Dear Colleagues,
Small molecule drugs have been the mainstay of the pharmaceutical industry for nearly a century. Defined as any organic compound with a low molecular weight, small molecule drugs have some distinct advantages as therapeutics: most can be administered orally, and they can pass through cell membranes to reach intracellular targets. They can also be designed to engage biological targets by various modes of action and their distribution can further be tailored, for example, to allow for systemic exposure with or without brain penetration. The rapid advancement of biopharmaceutical research and technology opens up possibilities for innovative and creative new approaches to developing small molecule drugs. Based on these considerations, this Special Issue aims to provide a platform for original research papers, short communications, and review articles on the latest advances in small molecule drugs. These papers may cover multidisciplinary aspects (such as drug design, synthesis, and pharmacological evaluation) of novel small molecule drugs with potential therapeutic innovations.
Dr. Elisa Magli
Prof. Dr. Beatrice Severino
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- small molecule drugs
- synthesis
- characterization
- medicinal chemistry
- biological activity
- drug delivery
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