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Molecules, Volume 29, Issue 18

September-2 2024 - 235 articles

Cover Story: Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by the formation of amyloid β and tau proteinopathies, impaired cholinergic transmission, oxidative stress and neuroinflammation, leading to neuronal loss and cognitive deficits. Chronic neuroinflammation plays a crucial role in AD progression, since the enhanced glial proinflammatory response can both facilitate and be further triggered by neuronal damage, thus creating a positive feedback loop. Mitogen-activated protein kinase (MAPK) p38α is one of the key enzymes regulating innate immune response, and its chronic activation is associated with excessive inflammation and other hallmarks of AD. This review summarizes the role of p38α MAPK in AD pathophysiology and provides insight into the therapeutic effects of novel MAPK inhibitors as a promising option for AD treatment. View this paper
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Articles (235)

  • Article
  • Open Access
4 Citations
1,870 Views
10 Pages

Identification of Key Volatile Compounds in Tilapia during Air Frying Process by Quantitative Gas Chromatography–Ion Mobility Spectrometry

  • Tianyu Chen,
  • Yong Xue,
  • Chunsheng Li,
  • Yongqiang Zhao,
  • Hui Huang,
  • Yang Feng,
  • Huan Xiang and
  • Shengjun Chen

23 September 2024

Air frying as a new roasting technology has potential for roasted fish production. In this study, the changes in volatile compounds (VCs) during air frying of tilapia were studied by quantitative gas chromatography–ion mobility spectrometry, fo...

  • Article
  • Open Access
3 Citations
1,532 Views
13 Pages

23 September 2024

In this work, a MoS2/C heterostructure was designed and prepared through an in situ composite method. The introduction of carbon during the synthesis process altered the morphology and size of MoS2, resulting in a reduction in the size of the flower-...

  • Article
  • Open Access
1 Citations
2,356 Views
10 Pages

A New Process for the Synthesis of Budesonide 21-Phosphate and Evaluation in a Murine Model of Inflammation

  • Angela Corvino,
  • Elisabetta Granato,
  • Antonia Scognamiglio,
  • Ferdinando Fiorino,
  • Francesco Frecentese,
  • Elisa Magli,
  • Elisa Perissutti,
  • Vincenzo Santagada,
  • Giuseppe Cirino and
  • Ida Cerqua
  • + 7 authors

23 September 2024

In this study, a new and straightforward process for the preparation of budesonide 21-phosphate (Bud-21P) and its disodium salt (Bud-21P-Na2) is described. The method results in a yield comparable to those obtained by diphosphoryl chloride, but it is...

  • Article
  • Open Access
1 Citations
1,618 Views
15 Pages

Broadband Solar Absorber and Thermal Emitter Based on Single-Layer Molybdenum Disulfide

  • Wanhai Liu,
  • Fuyan Wu,
  • Zao Yi,
  • Yongjian Tang,
  • Yougen Yi,
  • Pinghui Wu and
  • Qingdong Zeng

23 September 2024

In recent years, solar energy has become popular because of its clean and renewable properties. Meanwhile, two-dimensional materials have become a new favorite in scientific research due to their unique physicochemical properties. Among them, monolay...

  • Article
  • Open Access
1 Citations
1,529 Views
13 Pages

On the Simulation of Photoreactions Using Restricted Open-Shell Kohn–Sham Theory

  • Ralf Büchel,
  • Luis Álvarez,
  • Jan Grage,
  • Dominykas Maniscalco and
  • Irmgard Frank

23 September 2024

It is a well-established standard to describe ground-state chemical reactions at an ab initio level of multi-electron theory. Fast reactions can be directly simulated. The most widely used approach is density functional theory for the electronic stru...

  • Article
  • Open Access
3 Citations
1,789 Views
20 Pages

Cu-ZnO Embedded in a Polydopamine Shell for the Generation of Antibacterial Surgical Face Masks

  • Nicola d’Alessandro,
  • Francesca Coccia,
  • Luca Agostino Vitali,
  • Giorgia Rastelli,
  • Amedeo Cinosi,
  • Andrea Mascitti and
  • Lucia Tonucci

23 September 2024

A new easy protocol to functionalize the middle layer of commercial surgical face masks (FMs) with Zn and Cu oxides is proposed in order to obtain antibacterial personal protective equipment. Zinc and copper oxides were synthesized embedded in a poly...

  • Article
  • Open Access
3 Citations
1,369 Views
16 Pages

Mono- and Binuclear Complexes in a Centrifuge-Less Cloud-Point Extraction System for the Spectrophotometric Determination of Zinc(II)

  • Kiril B. Gavazov,
  • Petya V. Racheva,
  • Antoaneta D. Saravanska,
  • Fatma Genc and
  • Vassil B. Delchev

23 September 2024

The hydrophobic reagent 6-hexyl-4-(2-thiazolylazo)resorcinol (HTAR) was investigated as part of a cloud-point extraction (CPE) system for the spectrophotometric determination of Zn(II). In the system, complexes with different stoichiometries, includi...

  • Article
  • Open Access
3 Citations
3,296 Views
16 Pages

Formulating Sustainable Emulsions: Mandelic Acid and Essential Oils as Natural Preservatives

  • Jana Pavlačková,
  • Pavlína Egner,
  • Pavel Mokrejš and
  • Magda Janalíková

23 September 2024

Emulsion products with natural antimicrobials are becoming increasingly popular for topical application. Mandelic Acid is interesting in cosmetics due to its potent exfoliating properties, which have driven advancements in skincare technologies. Esse...

  • Review
  • Open Access
14 Citations
4,637 Views
26 Pages

23 September 2024

Carbon dots (CDs) are attracting increasing research attention due to their exceptional attributes, including their biocompatibility, water solubility, minimal toxicity, high photoluminescence, and easy functionalization. Green CDs, derived from natu...

  • Article
  • Open Access
1 Citations
2,148 Views
14 Pages

23 September 2024

A highly accurate, precise, and simple liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for ketotifen (KTF) estimation from Beagle dog plasma was developed and validated, with ketotifen-d3 (KTF-d3) as the internal standard (IS)....

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Molecules - ISSN 1420-3049