42 Results Found

Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) has become an attractive therapeutic strategy for lowering low-density lipoprotein cholesterol (LDL-C). In this study, a novel high affinity humanized IgG1 mAb (named h5E12-L230G) ta...

Hydrate formation/dissociation of natural gas in (diesel oil + water) emulsion systems containing 3 wt% anti-agglomerant were performed for five water cuts: 5, 10, 15, 20, and 25 vol%. The natural gas solubilities in the emulsion systems were also ex...

The oxidation/weathering of molybdenite (MoS2) is too slow to be monitored, even under pure oxygen and high temperatures, while it proceeds rapidly through humid air. The adsorption of water molecules on molybdenite is necessary for the wet oxidation...

The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein β-catenin acts as the si...

Many enzymes are known to change conformations during their catalytic cycle, but the role of these protein motions is not well understood. Escherichia coli dihydrofolate reductase (DHFR) is a small, flexible enzyme that is often used as a model syste...

Hydrate-based technologies have excellent application potential in gas separation, gas storage, transportation, and seawater desalination, etc. However, the long induction time and the slow formation rate are critical factors affecting the applicatio...

The photodissociation dynamics of CF2BrCF2I in CCl4 at 280 ± 2 K were investigated by probing the C−F stretching mode from 300 fs to 10 μs after excitation at 267 nm using time-resolved infrared spectroscopy. The excitation led to the...

Polyampholytes (PAs) exhibit complex behaviors in various environments influenced by their charge distribution. This study focuses on the kinetics of dimerization of PAs, aiming to elucidate the underlying mechanisms and clarify relevant characterist...

Lapatinib is an approved therapeutic agent for the treatment of HER2-positive breast cancer. It has a high affinity for the non-receptor cytoplasmic tyrosine kinases of the EGFR and HER2 receptors. It is a type II inhibitor, with Kiapp values of 3 nM...

The effect of the mobile interconversion of [RuHCl(CO)(mtppms-Na)3] 1, and [RuH(H2O)(CO)(mtppms-Na)3]+ 2, was studied in hydrogenation of phenylacetylene and cinnamaldehyde in aqueous–organic biphasic systems, as a function of the chloride...

The problem of hydrogen embrittlement in ultra-high-strength steels is well known. In this study, slow strain rate, four-point bending, and permeation tests were performed with the aim of characterizing innovative materials with an ultimate tensile s...

The hydrogen gasochromic phenomenon offers a new strategy for real-time sensing technologies for hydrogen leakage to ensure hydrogen safety. However, the limited recovery kinetics impede the cycling and further practical applications. Herein, we desi...

Galectins are β-galactoside-binding proteins implicated in a myriad of biological functions. Despite their highly conserved carbohydrate binding motifs with essentially identical structures, their affinities for lactose, a common galectin inhibitor,...

Aptamers or chemical antibodies are single-stranded DNA or RNA oligonucleotides that bind proteins and small molecules with high affinity and specificity by recognizing tertiary or quaternary structures as antibodies. Aptamers can be easily produced...

Permeability is one of the key factors that determine the fluids flow capacity and production potential of hydrate deposits. In this study, an experimental setup is developed to investigate the flow properties of the porous media, and the permeabilit...

The goal of this study is to develop a method to distinguish between plasma chemistry and thermal effects in a Dielectric Barrier Discharge nonequilibrium plasma containing a packed bed of porous particles. Decomposition of CaCO3 in Ar plasma is used...

Cells polarize for growth, motion, or mating through regulation of membrane-bound small GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP exchange factors) and inhibitors (GAPs, GTPase activating proteins) provide p...

The initial channels of thermal decomposition mechanism of 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105) molecule were investigated. The results of quantum chemical calculations revealed four candidates involved in the reaction pathway, including...

In this work, a gas hydrate formation and dissociation study was performed on two multiphase pipeline systems containing gasoline, CO2, water, and crude oil, CO2, water, in the pressure range of 2.5–3.5 MPa with fixed water cut as 15% using gas...

The thermodynamic, kinetic, and structural properties of Ln3+ complexes with the bifunctional DO3A-ACE4− ligand and its amide derivative DO3A-BACE4− (modelling the case where DO3A-ACE4− ligand binds to vector molecules) have been studied in order to...

Photocatalysis technology is a potential solution to solve the problem of environmental pollution and energy shortage, but its wide application is limited by the low efficiency of solar energy conversion. As a non-toxic and inexpensive n-type semicon...

4-Azidopyridine (1) and SiCl4 react with the formation of the hexacoordinate silicon complex SiCl4(4-azidopyridine)2 (2). Upon dissolving in warm chloroform, the complex dissociates into the constituents 1 and SiCl4 and forms back upon cooling. Depen...

Background/Objectives: Hypnosis shows great potential for managing patients suffering from fibromyalgia and chronic pain. Several studies have highlighted its efficacy in improving pain, quality of life, and reducing psychological distress. Despite i...

Recommendations for endurance exercise prescription are often based on percentages of heart rate (HR) or the volume of oxygen consumption (V˙O2) maximum or reserve that is extrapolated to a power output (P) or velocity. Previous work has demonst...

Using dynamic liquid-state NMR spectroscopy a degenerate double proton tautomerism was detected in tetramethyl reductic acid (TMRA) dissolved in toluene-d8 and in CD2Cl2. Similar to vitamin C, TMRA belongs to the class of reductones of biologically i...

A stable temperature site and the speed of heating the feedstocks play a key role in pyrolysis processes. In this study, the product distribution arising from pyrolysis of methyl ricinoleate (MR) at 550 °C with low and high heating rates was firs...

Transient polymer networks are ubiquitous in natural and engineered materials and contain cross-links that can reversibly break and re-form. The dynamic nature of these bonds allows for interesting mechanical behavior, some of which include nonlinear...

Video and music as a dissociative attention stimulus during exercise is known to distract from the discomfort of physical exertion and improve exercise adherence; however, the influence of video-based feedback and engagement during pedalling on the p...

The oral bioavailability of curcumin is inherently low, which significantly limits its application in food systems. The objective of this study was to evaluate the impact of high-pressure processing on the stability and bioaccessibility of curcumin w...

Lacosamide (Vimpat®, LCS) is widely known as a functionalized amino acid with promising anti-convulsant properties; however, adverse events during its use have gradually appeared. Despite its inhibitory effect on voltage-gated Na+ current (INa),...

Nucleic acid aptamers are artificial recognizing molecules that are capable of specific binding to a wide variety of targets. Aptamers are commonly selected from a huge library of oligonucleotides and improved by introducing several mutations or modu...

(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was a...

Positron emission tomography (PET) radioligands that bind with high-affinity to α4β2-type nicotinic receptors (α4β2Rs) allow for in vivo investigations of the mechanisms underlying nicotine addiction and smoking cessation. Here,...

Myoblast fusion into functionally-distinct myotubes to form in vitro skeletal muscle constructs under differentiation serum-free conditions still remains a challenge. Herein, we report that our microtopographical carbohydrate substrates composed of b...

Ethanol is considered an alternative fuel to power fuel cells, especially due to its ease of transport and storage and renewable production on a large scale. However, its use in direct ethanol fuel cells (DEFC) is still limited by incomplete electro-...

Huge amounts of natural gas hydrate are trapped in an ice-like structure (hydrate). Most of these hydrates have been formed from biogenic degradation of organic waste in the upper crust and are almost pure methane hydrates. With up to 14 mol% methane...

Cell-penetrating peptides (CPPs) are short peptide sequences that have the ability to cross the cell membrane and deliver cargo. Although it is critical that CPPs accomplish this task with minimal off-target effects, such actions have in many cases n...

Interleukin-18 (IL-18) serves a dual function in the immune system, acting as a “double-edged sword” cytokine. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. Pathol...

Integration host factor (IHF) is a nucleoid-associated protein involved in DNA packaging, integration of viral DNA and recombination. IHF binds with nanomolar affinity to duplex DNA containing a 13 bp consensus sequence, inducing a bend of ~160°...

In this manuscript, two thiouronium-based ionic liquids (ILs), namely 2-ethylthiouronium bromide [C2th][Br] and 2-(hydroxyethyl)thiouronium bromide [C2OHth][Br], were tested at different concentrations (1 and 10 wt%) for their ability to affect CO2 (...

This work introduces the synthesis of hybrid polymer electrolytes based on polyethylene oxide (PEO) and electrolyte solution bis(trifluoromethane)sulfonimide lithium salt/ionic liquid 1-ethyl-3-methyl-imidazolium bis(trifluoromethylsulfonyl)imide (Li...

The heart rate slow component (scHR) is an intensity-dependent HR increment that emerges during constant exercises, partially dissociated from metabolism (V˙O2). The scHR has been observed during constant-workload exercise in young and older adu...