Biologically active compounds from the 1,3,4-thiadiazol-2-yl)-benzene-1,3-diols group described earlier have been studied. Various approaches were used to determine their lipophilicity and predict pharmacokinetic properties. The lipophilicity paramet...
The BCF (bioconcentration factor) of solutes in aquatic organisms is an important parameter because many undesired chemicals enter the ecosystem and affect the wildlife. Chromatographic retention factor log kwIAM obtained from immobilized artificial...
The relationship between the herbicidal activity of a number of novel 1,2,5-oxadiazole N-oxides and some physicochemical properties potentially related with thisbioactivity, such as polarity, molecular volume, proton acceptor ability, lipophilicity,...
The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the d...
This research was carried out in a selection stand of beech and fir, where logging was performed with chainsaws of different powers. Two chainsaws of 3.9 kW were used for work on one area, while on the other one the applied tools were a combination o...
A batch of pine timber sawn from butt, middle and top logs was strength graded with the visual method (classification into grading classes KW—best quality, KS—medium quality, KG—inferior quality and Reject) and with the machine strength grading metho...
This study represents the first-time experimental analysis of lipophilicity for antidiabetic drugs from the gliflozin class using chromatographic methods alongside computational approaches. The lipophilicity of five gliflozins (canagliflozin (CANA),...
This research focused on a three-step synthesis, analytical, physicochemical, and biological evaluation of hybrid molecules 6a–g, containing a lipophilic 3-trifluoromethylphenyl moiety, polar carbamoyloxy bridge, 2-hydroxypropan-1,3-diyl chain...
Lipophilicity is a crucial parameter for drug discovery, usually determined by the logarithmic partition coefficient (Log P) between octanol and water. However, the available detection methods have restricted the widespread use of the partition coeff...
The permeation of the blood-brain barrier is a very important consideration for new drug candidate molecules. In this research, the reversed-phase liquid chromatography with different columns (Purosphere RP-18e, IAM.PC.DD2 and Cosmosil Cholester) was...
Nine new dihydrochloride salts of 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-alkoxyethoxybenzoates were designed and synthesized. The physicochemical properties such as lipophilicity index (log kw) and dissociation constant (pKa) were experimentally...
In order to provide a more detailed view on the structure–antimycobacterial activity relationship (SAR) of phenylcarbamic acid derivatives containing two centers of protonation, 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(dipropylammonio)prop...
The consumer demand for organic food including apples is increasing worldwide. Despite favorable environmental and health benefits, organic farming bears also disadvantages like high amounts of fruit losses due to storage rot. A novel treatment with...
Penetration through the blood-brain barrier (BBB) is desirable in the case of potential pharmaceuticals acting on the central nervous system (CNS), but is undesirable in the case of drug candidates acting on the peripheral nervous system because it m...
In this study, novel spore pouches were developed using mashed potato as a food model inoculated with either Geobacillus stearothermophilus or Clostridium sporogenes spores. These spore pouches were used to evaluate the sterilization efficiency of Co...
α-Klotho (Klotho) is an antiaging hormone with anti-inflammatory and antioxidative properties. Some studies suggest that Klotho increases in response to enhanced oxidative damage and inflammation. Alcoholism is a proinflammatory condition. The...
Pseudothiohydantoin derivatives have a wide range of biological activities and are widely used in the development of new pharmaceuticals. Lipophilicity is a basic, but very important parameter in the design of potential drugs, as it determines solubi...
Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug can...
Understanding the adoption patterns of clean energy is crucial for designing government subsidies that promote the use of these technologies. Existing work has examined a variety of adoption models to explain and predict how economic factors and othe...
Photovoltaic installations can be environmentally beneficial to a greater or lesser extent, depending on the conditions. If the energy produced is not used, it is redirected to the grid, otherwise a battery with a high ecological footprint is needed...
This paper presents a techno-economic assessment of the wind power potential for eight locations distributed over the Northern part of Cyprus. The wind speed data were collected from the meteorological department located in Lefkoşa, Northern Cyprus.T...
Background/Objectives: The widespread use of sulfamethoxazole (SMX) has led to increasing antibiotic resistance, and there is a need for improved formulations to enhance its therapeutic effectiveness. In this study, we investigated the biocidal poten...
The aim of this work is to assess the effectiveness of biomass gasification power plants in Russia (Irkutsk region) and compare them with other types of electricity and heat cogeneration systems. Biomass, which is waste from logging and wood processi...
Spring harvested corn stover was used for direct combustion in a 146 kW dual chamber boiler designed for wood logs. Stover had a very low moisture content (6.83 ± 0.17%), a gross calorific value (GCV) of 18.57 MJ/kg of dry matter (±0.32 MJ/kg DM) and...
In this study, a new device was used to inactivate G. stearothermophilus spores in ready-to-eat (RTE) poached spicy pork slices (PSPS) applying radio frequency (RF) energy (27.12 MHz, 6 kW) and superheated water (SW) simultaneously. The cold spot in...
Novel 1-(2-{3-/4-[(alkoxycarbonyl)amino]phenyl}-2-hydroxyethyl)-4-(2-fluorophenyl)-piperazin-1-ium chlorides (alkoxy = methoxy to butoxy; 8a–h) have been designed and synthesized through multistep reactions as a part of on-going research programme fo...
A series of thirty novel tetracarboxylatoplatinum(IV) complexes in trans-configuration featuring combinations of mixed ammine, methylamine, dimethylamine, and cyclopentylamine ligands as well as acetato/propanoato and trifluoropropanoato ligands was...
There is an increasing interest in new renewable energy sources for achieving net zero emissions. Consequently, the construction industry has mandated zero-energy building certification (ZEB), through the usage of new renewable energy. However, becau...
Background: Determination of psychotropic drugs in clinical study is significant, and the establishment of methodologies for these drugs in biological matrices is essential for patients’ safety. The search for new methods for their detection is...
In this study, we evaluated the effectiveness of UV-LED-irradiated TiO2 in removing 24 commonly detected PPCPs in two water matrices (municipal wastewater effluent and Suwannee River NOM–synthetic water) and compared their performance with that of ul...
This study focused on small gasification units for combined heat and power generation (CHP) up to 200 kW of electric power, which can use wood from salvage logging, and assessed the current feasibility of running commercially available units in the c...
An experimental fire was conducted in one-year-old mulched (masticated) boreal fuels, where all aboveground biomass was mulched with no stems removed or left standing. Typical mulching practices remove remnant biomass; leaving biomass in situ reduces...
The aim of the present work was to estimate the productivity and costs of timber harvesting and forwarding during the first commercial thinning of a Scots pine stand. Three harvesting models were introduced and compared: narrow trail, wide access tra...
The drilling fluid cooling system is a key technology for reducing wellbore temperatures, improving the working environment of downhole equipment, and ensuring safe and efficient drilling in high-temperature wells. Based on the existing drilling flui...