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37 Results Found

  • Review
  • Open Access
24 Citations
3,885 Views
14 Pages

9 December 2020

Canola co-products are widely included in swine diets as sources of proteins. However, inclusion of canola co-products in diets for pigs is limited by toxicity of glucosinolate degradation products. Aliphatic and aromatic glucosinolates are two major...

  • Article
  • Open Access
18 Citations
3,649 Views
18 Pages

Glucosinolate-Degradation Products as Co-Adjuvant Therapy on Prostate Cancer in Vitro

  • María Jesús Núñez-Iglesias,
  • Silvia Novío,
  • Carlota García,
  • Elena Pérez-Muñuzuri,
  • Pilar Soengas,
  • Elena Cartea,
  • Pablo Velasco and
  • Manuel Freire-Garabal

9 October 2019

Glucosinolate-degradation products (GS-degradation products) are believed to be responsible for the anticancer effects of cruciferous vegetables. Furthermore, they could improve the efficacy and reduce side-effects of chemotherapy. The aim of the pre...

  • Article
  • Open Access
32 Citations
4,700 Views
15 Pages

Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race

  • Marijana Popović,
  • Ana Maravić,
  • Vedrana Čikeš Čulić,
  • Azra Đulović,
  • Franko Burčul and
  • Ivica Blažević

21 February 2020

Horseradish degradation products, mainly isothiocyanates (ITC) and nitriles, along with their precursors glucosinolates, were characterized by GC-MS and UHPLC-MS/MS, respectively. Volatiles from horseradish leaves and roots were isolated using microw...

  • Review
  • Open Access
107 Citations
18,494 Views
25 Pages

Glucosinolate Biosynthesis and the Glucosinolate–Myrosinase System in Plant Defense

  • Shweta Chhajed,
  • Islam Mostafa,
  • Yan He,
  • Maged Abou-Hashem,
  • Maher El-Domiaty and
  • Sixue Chen

14 November 2020

Insect pests represent a major global challenge to important agricultural crops. Insecticides are often applied to combat such pests, but their use has caused additional challenges such as environmental contamination and human health issues. Over mil...

  • Article
  • Open Access
18 Citations
3,552 Views
11 Pages

Microwave-Assisted versus Conventional Isolation of Glucosinolate Degradation Products from Lunaria annua L. and Their Cytotoxic Activity

  • Ivica Blažević,
  • Azra Đulović,
  • Vedrana Čikeš Čulić,
  • Marijana Popović,
  • Xavier Guillot,
  • Franko Burčul and
  • Patrick Rollin

1 February 2020

Glucosinolates (GSLs) from Lunaria annua L. seeds were analyzed qualitatively and quantitatively by their desulfo counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products, isothiocyanates (ITCs), using GC-MS technique. GS...

  • Article
  • Open Access
425 Views
18 Pages

Glucosinolate-Derived Metabolites from Barbarea vulgaris (Brassicaceae): Evaluation of Antimicrobial, Antioxidant, and Anti-Inflammatory Potentials

  • Elvira Mavrić-Scholze,
  • Amina Gusinac,
  • Milan Dekić,
  • Ivan Palić,
  • Edina Avdović,
  • Dušica Simijonović,
  • Mirjana Grujović,
  • Katarina Marković,
  • Vladimir Dobričić and
  • Niko Radulović
  • + 1 author

30 November 2025

Glucosinolate-derived metabolites play central roles in plant defense and are increasingly recognized for their pharmacological importance. Barbarea vulgaris produces a structurally diverse set of such compounds, yet their biological activities remai...

  • Article
  • Open Access
22 Citations
4,561 Views
14 Pages

Glucosinolates and Isothiocyantes in Processed Rapeseed Determined by HPLC-DAD-qTOF

  • Ana Miklavčič Višnjevec,
  • Angelica Tamayo Tenorio,
  • Anne Christine Steenkjær Hastrup,
  • Natanya Majbritt Louie Hansen,
  • Kelly Peeters and
  • Matthew Schwarzkopf

22 November 2021

Glucosinolates are well known as natural antimicrobials and anticarcinogenic agents. However, these compounds can lose their properties and transform into antinutrients, depending on processing conditions. In addition, the bitterness of some glucosin...

  • Article
  • Open Access
17 Citations
4,132 Views
16 Pages

12 August 2021

Most literature data indicate that the diet rich in plant products reduces the risk of developing chronic non-communicable diseases and cancer. Brassica vegetables are almost exclusively synthesizing glucosinolates. Glucosinolates are higher in sprou...

  • Article
  • Open Access
9 Citations
3,227 Views
14 Pages

Eco-Efficient Quantification of Glucosinolates in Camelina Seed, Oil, and Defatted Meal: Optimization, Development, and Validation of a UPLC-DAD Method

  • Salvador Meza,
  • Yucheng Zhou,
  • Jonathan Chastain,
  • Yingying Yang,
  • Hope Hua Cheng,
  • Diliara Iassonova,
  • Jason Rivest and
  • Hong You

10 December 2022

Camelina sativa (camelina) seed, oil, and defatted meal are widely used for food, animal feed, and other purposes. The accurate quantification of camelina glucosinolates is critical as their functionalities are highly dose-dependent. The classic quan...

  • Article
  • Open Access
21 Citations
3,890 Views
11 Pages

Bunias erucago L.: Glucosinolate Profile and In Vitro Biological Potential

  • Ivica Blažević,
  • Azra Đulović,
  • Vedrana Čikeš Čulić,
  • Franko Burčul,
  • Ivica Ljubenkov,
  • Mirko Ruščić and
  • Ivana Generalić Mekinić

19 February 2019

Bunias erucago belongs to the Brassicaceae family, which represents a forgotten crop of the Euro-Mediterranean area. The aim of the present study was to determine the glucosinolate profile in different plant parts and biological properties (antioxida...

  • Article
  • Open Access
2 Citations
1,837 Views
15 Pages

Nitrile-Specific Protein NSP2 and Its Interacting Protein MPK3 Synergistically Regulate Plant Disease Resistance in Arabidopsis

  • Tingting Zhai,
  • Jun Teng,
  • Xintong Fan,
  • Shaowei Yu,
  • Chen Wang,
  • Xingqi Guo,
  • Wei Yang and
  • Shuxin Zhang

3 August 2023

Glucosinolates and their degradation products have a wide range of actions and are important components of plant defense. NSP2 (nitrile-specific protein 2) is a key regulator in the breakdown process of glucosinolates. However, the precise function o...

  • Article
  • Open Access
5 Citations
1,723 Views
16 Pages

The RNA-Binding Protein BoRHON1 Positively Regulates the Accumulation of Aliphatic Glucosinolates in Cabbage

  • Xue Bai,
  • Ruixing Zhang,
  • Qi Zeng,
  • Wenjing Yang,
  • Fang Fang,
  • Qingguo Sun,
  • Chengtai Yan,
  • Fangguan Li,
  • Xifan Liu and
  • Baohua Li

Aliphatic glucosinolates are an abundant group of plant secondary metabolites in Brassica vegetables, with some of their degradation products demonstrating significant anti-cancer effects. The transcription factors MYB28 and MYB29 play key roles in t...

  • Article
  • Open Access
2 Citations
1,604 Views
12 Pages

30 November 2024

Nitrilases, found to have a common presence in the plant kingdom, are capable of converting nitriles into their corresponding carboxylic acids through hydrolysis. In Arabidopsis, the nitrilases NIT1, NIT2, and NIT3 catalyze the formation of indole-3-...

  • Article
  • Open Access
885 Views
23 Pages

20 October 2025

Background: Broccoli contains diverse phytochemicals, including glucosinolates and their hydrolysis products, with potential nutritional and bioactive properties. Accurate metabolite profiling requires optimized sample preparation and comprehensive d...

  • Article
  • Open Access
38 Citations
12,753 Views
19 Pages

Piriformospora indica Stimulates Root Metabolism of Arabidopsis thaliana

  • Nadine Strehmel,
  • Susann Mönchgesang,
  • Siska Herklotz,
  • Sylvia Krüger,
  • Jörg Ziegler and
  • Dierk Scheel

Piriformospora indica is a root-colonizing fungus, which interacts with a variety of plants including Arabidopsis thaliana. This interaction has been considered as mutualistic leading to growth promotion of the host. So far, only indolic glucosinolat...

  • Article
  • Open Access
2 Citations
2,062 Views
16 Pages

Upcycling low-cost agricultural by-products into valuable and sustainable alternative feeding materials could secure human food-supply chains with a low carbon footprint. This study explored increasing the feeding value of camelina meal (CAM) mixed w...

  • Abstract
  • Open Access
3 Citations
2,008 Views
1 Page

Brassica Biofumigants for Improved Soil Health

  • Gayathri Rajagopal,
  • John Duff and
  • Zara Hall

Biofumigation involves growing specialised cover crops that have the ability to suppress certain soil-borne diseases. Species such as those in the Brassicaceae family, (e.g., radish, mustard and rocket) are known to have this capability. Biofumigatio...

  • Article
  • Open Access
1 Citations
1,593 Views
12 Pages

The Effects of Different Thiol-Containing Compounds on the Degradation of Sulforaphene

  • Rui Gao,
  • Pingxiang Liu,
  • Jingxiu Bi,
  • Yuying Jiang,
  • Tong Zhao,
  • Xuexia Yuan,
  • Chao Zhang and
  • Yutao Wang

12 September 2024

Sulforaphene (4-methylsufinyl-3-butenyl isothiocyanate, SFE), produced by myrosinase hydrolysis of glucoraphenin (4-methylsulfinyl-3-butenyl glucosinolate) found in radish seeds, is strongly associated with cancer prevention. In this study, we invest...

  • Article
  • Open Access
10 Citations
3,679 Views
15 Pages

Bioactives and Technological Quality of Functional Biscuits Containing Flour and Liquid Extracts from Broccoli By-Products

  • Benedetta Fanesi,
  • Lama Ismaiel,
  • Ancuta Nartea,
  • Oghenetega Lois Orhotohwo,
  • Anastasiya Kuhalskaya,
  • Deborah Pacetti,
  • Paolo Lucci and
  • Pasquale Massimiliano Falcone

14 December 2023

Broccoli by-products are an important source of health-promoting bioactive compounds, although they are generally underutilized. This study aimed to valorize non-compliant broccoli florets by transforming them into functional ingredients for biscuit...

  • Review
  • Open Access
10 Citations
11,399 Views
31 Pages

Glucosinolates in Human Health: Metabolic Pathways, Bioavailability, and Potential in Chronic Disease Prevention

  • Sara Baldelli,
  • Mauro Lombardo,
  • Alfonsina D’Amato,
  • Sercan Karav,
  • Gianluca Tripodi and
  • Gilda Aiello

7 March 2025

Glucosinolates (GSLs) are sulfur-containing compounds predominantly found in cruciferous vegetables such as broccoli, kale, and Brussels sprouts, and are recognized for their health-promoting properties. Upon consumption, GSLs undergo hydrolysis by t...

  • Article
  • Open Access
1 Citations
2,438 Views
14 Pages

Effect of Fermentation Conditions on Functional Quality of Napa Cabbage Kimchi

  • Jaecheol Kim,
  • Hyosun Park,
  • BoKyung Moon and
  • Suna Kim

15 August 2025

This study investigated the effects of storage temperature on the functional quality of kimchi during short- and long-term fermentation. Pretreated napa cabbage (NC) quality was analyzed, and kimchi was prepared using pretreated NC and stored at eith...

  • Feature Paper
  • Review
  • Open Access
319 Citations
30,553 Views
26 Pages

8 January 2021

This review article introduces nutrition and functional food ingredients, explaining the widely cited terms of bioactivity, bioaccessibility, and bioavailability. The factors affecting these critical properties of food components are analyzed togethe...

  • Article
  • Open Access
7 Citations
3,477 Views
21 Pages

Immunomodulatory and Antioxidant Effects of Spray-Dried Encapsulated Kale Sprouts after In Vitro Gastrointestinal Digestion

  • Erika Ortega-Hernández,
  • Ana Victoria Camero-Maldonado,
  • Laura Acevedo-Pacheco,
  • Daniel A. Jacobo-Velázquez and
  • Marilena Antunes-Ricardo

26 May 2023

The health-related compounds present in kale are vulnerable to the digestive process or storage conditions. Encapsulation has become an alternative for their protection and takes advantage of their biological activity. In this study, 7-day-old Red Ru...

  • Review
  • Open Access
1 Citations
3,176 Views
30 Pages

Nutritional, Therapeutic, and Functional Food Perspectives of Kale (Brassica oleracea var. acephala): An Integrative Review

  • Aleksandra Łukaszyk,
  • Inga Kwiecień,
  • Anita Kanik,
  • Eliza Blicharska,
  • Małgorzata Tatarczak-Michalewska,
  • Wojciech Białowąs,
  • Katarzyna Czarnek and
  • Agnieszka Szopa

28 October 2025

Kale (Brassica oleracea var. acephala) is a non-heading leafy vegetable of the Brassicaceae family, widely recognized for its dense nutritional profile and diverse phytochemical composition. This review provides a comprehensive and up-to-date synthes...

  • Proceeding Paper
  • Open Access
1 Citations
1,937 Views
4 Pages

Pancreatic adenocarcinoma mainly occurs in elderly people. Thus, the management of pancreatic cancer in the aging population is becoming increasingly relevant. In this preliminary study we evaluated the effect of selected phytochemicals and their com...

  • Article
  • Open Access
6 Citations
1,960 Views
15 Pages

31 August 2023

Sulfur is an essential element for plant growth, development and resistance to environmental stresses. Glucosinolates (GSLs), a group of sulfur rich secondary metabolites found in Brassicaceae plants, are known for their defensive properties against...

  • Article
  • Open Access
20 Citations
3,869 Views
17 Pages

A New Food Ingredient Rich in Bioaccessible (Poly)Phenols (and Glucosinolates) Obtained from Stabilized Broccoli Stalks

  • Antonio Costa-Pérez,
  • Diego A. Moreno,
  • Paula M. Periago,
  • Cristina García-Viguera and
  • Raúl Domínguez-Perles

14 June 2022

Broccoli (Brassica oleracea var. italica) stalks account for up to 35% of the broccoli harvest remains with the concomitant generation of unused waste that needs recovery to contribute to the sustainability of the system. However, due to its phytoche...

  • Review
  • Open Access
33 Citations
8,229 Views
34 Pages

Brassica Genus Seeds: A Review on Phytochemical Screening and Pharmacological Properties

  • Jawaher Ayadi,
  • Mohamed Debouba,
  • Rami Rahmani and
  • Jalloul Bouajila

15 September 2022

Traditionally, Brassica species are widely used in traditional medicine, human food, and animal feed. Recently, special attention has been dedicated to Brassica seeds as source of health-promoting phytochemicals. This review provides a summary of rec...

  • Review
  • Open Access
24 Citations
15,354 Views
28 Pages

Current Methods for the Extraction and Analysis of Isothiocyanates and Indoles in Cruciferous Vegetables

  • Sofia Karanikolopoulou,
  • Panagiota-Kyriaki Revelou,
  • Marinos Xagoraris,
  • Maroula G. Kokotou and
  • Violetta Constantinou-Kokotou

24 September 2021

Cruciferous vegetables are characterized by the presence of sulfur-containing secondary plant metabolites known as glucosinolates (GLS). The consumption of cruciferous vegetables such as broccoli, cabbage, rocket salad, and cauliflower has been relat...

  • Review
  • Open Access
37 Citations
8,542 Views
28 Pages

Effects of Brassicaceae Isothiocyanates on Prostate Cancer

  • Silvia Novío,
  • María Elena Cartea,
  • Pilar Soengas,
  • Manuel Freire-Garabal and
  • María Jesús Núñez-Iglesias

Despite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men. The effective management of this disease requires...

  • Review
  • Open Access
2,572 Views
65 Pages

Neurodegenerative, neurodevelopmental, and psychiatric disorders, as well as epilepsy, affect millions of people. Due to their impact on patients’ quality of life, they represent a major health issue. Natural compounds are arising as new treatm...

  • Article
  • Open Access
1,437 Views
32 Pages

Blackleg disease poses a major threat to global canola production. The resistance gene Rlm1, corresponding to the avirulence gene AvrLm1 in the pathogen Leptosphaeria maculans, has been widely used to mitigate the impact of the disease. To inves...

  • Editorial
  • Open Access
49 Citations
5,423 Views
6 Pages

Advances in Plant Sulfur Research

  • Dimitris L. Bouranis,
  • Mario Malagoli,
  • Jean-Christophe Avice and
  • Elke Bloem

17 February 2020

As an essential nutrient required for plant growth and development, sulfur (S) deficiency in productive systems limits yield and quality. This special issue hosts a collection of original research articles, mainly based on contributions from the 11th...

  • Feature Paper
  • Article
  • Open Access
13 Citations
7,268 Views
10 Pages

4 November 2016

Recent studies showed that Brassica vegetables are rich in numerous health-promoting compounds such as carotenoids, polyphenols, flavonoids, and glucosinolates (GLS), as well as isothiocyanates (ITCs) and are involved in health promotion upon consump...

  • Article
  • Open Access
1 Citations
2,610 Views
19 Pages

Formation of DNA Adducts by 1-Methoxy-3-indolylmethylalcohol, a Breakdown Product of a Glucosinolate, in the Mouse: Impact of the SULT1A1 Status—Wild-Type, Knockout or Humanised

  • Hansruedi Glatt,
  • Sarah Yasmin Weißenberg,
  • Anke Ehlers,
  • Alfonso Lampen,
  • Albrecht Seidel,
  • Fabian Schumacher,
  • Wolfram Engst and
  • Walter Meinl

We previously found that feeding rats with broccoli or cauliflower leads to the formation of characteristic DNA adducts in the liver, intestine and various other tissues. We identified the critical substances in the plants as 1-methoxy-3-indolylmethy...

  • Review
  • Open Access
63 Citations
71,722 Views
33 Pages

Carica papaya L.: A Tropical Fruit with Benefits beyond the Tropics

  • Bhupendra Koul,
  • Baveesh Pudhuvai,
  • Chelsi Sharma,
  • Arvind Kumar,
  • Vinay Sharma,
  • Dhananjay Yadav and
  • Jun-O Jin

20 August 2022

Carica papaya L. (family: Caricaceae), also known as ‘papaya,’ is a tropical American fruit tree. Due to the bioactive components (carpaines, BITC, benzyl glucosinolates, latex, papain, zeaxanthin, choline, etc.) in its seeds, leaves, and...

  • Article
  • Open Access
9 Citations
3,812 Views
16 Pages

Significant Benefits of Environmentally Friendly Hydrosols from Tropaeolum majus L. Seeds with Multiple Biological Activities

  • Ivana Vrca,
  • Blaž Jug,
  • Željana Fredotović,
  • Elma Vuko,
  • Valentina Brkan,
  • Loriana Šestić,
  • Lea Juretić,
  • Valerija Dunkić,
  • Marija Nazlić and
  • Dario Kremer
  • + 1 author

18 November 2023

Tropaeolum majus L. is a traditional medicinal plant with a wide range of biological activities due to the degradation products of the glucosinolate glucotropaeolin. Therefore, the goals of this study were to identify volatiles using gas chromatograp...