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31 Results Found

  • Article
  • Open Access
3 Citations
2,630 Views
11 Pages

Neonatal Bloodstream Infection with Ceftazidime-Avibactam-Resistant blaKPC-2-Producing Klebsiella pneumoniae Carrying blaVEB-25

  • Charalampos Zarras,
  • Elias Iosifidis,
  • Maria Simitsopoulou,
  • Styliani Pappa,
  • Angeliki Kontou,
  • Emmanuel Roilides and
  • Anna Papa

Background: Although ceftazidime/avibactam (CAZ/AVI) has become an important option for treating adults and children, no data or recommendations exist for neonates. We report a neonatal sepsis case due to CAZ/AVI-resistant blaKPC-2-harboring Klebsiel...

  • Article
  • Open Access
4 Citations
1,836 Views
12 Pages

Outbreak of High-Risk Clone ST323 Klebsiella pneumoniae Resistant to Ceftazidime–Avibactam Due to Acquisition of blaVEB-25 and to Cefiderocol Due to Mutated fiu Gene

  • Irene Galani,
  • Ilias Karaiskos,
  • Maria Souli,
  • Vassiliki Papoutsaki,
  • Aikaterini Gkoufa,
  • Anastasia Antoniadou and
  • Helen Giamarellou

21 February 2025

Background/Objectives: The incidence of Ceftazidime/Avibactam (CZA)-resistant Klebsiella pneumoniae isolate co-producing Klebsiella pneumoniae carbapenemase 2 (KPC-2) and Vietnamese extended-spectrum β-lactamase 25 (VEB-25) has been on the rise...

  • Article
  • Open Access
17 Citations
4,262 Views
15 Pages

Association of blaVIM-2, blaPDC-35, blaOXA-10, blaOXA-488 and blaVEB-9 β-Lactamase Genes with Resistance to Ceftazidime–Avibactam and Ceftolozane–Tazobactam in Multidrug-Resistant Pseudomonas aeruginosa

  • Mazen A. Sid Ahmed,
  • Faisal Ahmad Khan,
  • Hamad Abdel Hadi,
  • Sini Skariah,
  • Ali A. Sultan,
  • Abdul Salam,
  • Abdul Latif Al Khal,
  • Bo Söderquist,
  • Emad Bashir Ibrahim and
  • Ali S. Omrani
  • + 1 author

Ceftazidime–avibactam and ceftolozane–tazobactam are approved for the treatment of complicated Gram-negative bacterial infections including multidrug-resistant (MDR) Pseudomonas aeruginosa. Resistance to both agents has been reported, but...

  • Article
  • Open Access
1 Citations
2,132 Views
20 Pages

25 August 2024

Extensively drug-resistant P. aeruginosa (XDR-PA) has been highlighted as a serious public health threat. The present study aimed to explore the genomic characteristics of two Vietnamese extended-spectrum β-lactamase-9 (VEB-9)-producing XDR-PA i...

  • Article
  • Open Access
3 Citations
1,406 Views
13 Pages

Clonal Dissemination of NDM-Producing Proteus mirabilis in a Teaching Hospital in Sousse, Tunisia

  • Nadia Jaidane,
  • Lamia Tilouche,
  • Saoussen Oueslati,
  • Delphine Girlich,
  • Sana Azaiez,
  • Aymeric Jacquemin,
  • Laurent Dortet,
  • Walid Naija,
  • Abdelhalim Trabelsi and
  • Thierry Naas
  • + 2 authors

Proteus mirabilis (P. mirabilis) is an opportunistic pathogen involved in urinary tract infections as well as various nosocomial infections. Emerging resistances to beta-lactams in this species complicates potential treatment since it is intrinsicall...

  • Article
  • Open Access
3 Citations
1,810 Views
13 Pages

Report of High-Risk Carbapenem-Resistant K. pneumoniae ST307 Clone Producing KPC-2, SHV-106, CTX-M-15, and VEB-1 in Greece

  • Maria Chatzidimitriou,
  • Pandora Tsolakidou,
  • Maria Anna Kyriazidi,
  • Sotiris Varlamis,
  • Ilias S. Frydas,
  • Maria Mavridou and
  • Stella Mitka

Background/Objectives: Klebsiella pneumoniae ST307 is emerging as a significant global high-risk antimicrobial-resistant (AMR) clone with a notable capacity to acquire and disseminate resistance genes. However, there is limited research on the pathog...

  • Article
  • Open Access
4 Citations
6,093 Views
11 Pages

Enhanced Dispersion and Removal of Ammonia Emitted from a Poultry House with a Vegetative Environmental Buffer

  • Kyoung S. Ro,
  • Hong Li,
  • Cathleen J. Hapeman,
  • Lowry A. Harper,
  • Thomas K. Flesch,
  • Peter M. Downey,
  • Laura L. McConnell,
  • Alba Torrents and
  • Qi Yao

Vegetative environmental buffers (VEBs), which are composed of tolerant trees, shrubs, and tall grasses, can be used to control and reduce the transport of ammonia (NH3) emissions from animal feeding operations (AFOs). However, the effectiveness of V...

  • Article
  • Open Access
3 Citations
1,684 Views
9 Pages

Efficacy of Catheter Ablation Using the Electroanatomical System without the Use of Fluoroscopy in Patients with Ventricular Extrasystolic Beats

  • Dariusz Rodkiewicz,
  • Edward Koźluk,
  • Karol Momot,
  • Karolina Rogala,
  • Agnieszka Piątkowska,
  • Małgorzata Buksińska-Lisik,
  • Przemysław Kwasiborski and
  • Artur Mamcarz

24 July 2023

Background: Catheter ablation (CA) has become safe and efficient for the treatment of patients with ventricular extrasystolic beats (VEBs). The three-dimensional electroanatomic mapping (EAM) system allows the elimination of fluoroscopy time during C...

  • Technical Note
  • Open Access
9 Citations
9,767 Views
13 Pages

The Da Vinci European BioBank: A Metabolomics-Driven Infrastructure

  • Dario Carotenuto,
  • Claudio Luchinat,
  • Giordana Marcon,
  • Antonio Rosato and
  • Paola Turano

22 April 2015

We present here the organization of the recently-constituted da Vinci European BioBank (daVEB, https://www.davincieuropeanbiobank.org/it). The biobank was created as an infrastructure to support the activities of the Fiorgen Foundation (http://www.fi...

  • Article
  • Open Access
42 Citations
12,755 Views
14 Pages

Arrhythmia Evaluation in Wearable ECG Devices

  • Muammar Sadrawi,
  • Chien-Hung Lin,
  • Yin-Tsong Lin,
  • Yita Hsieh,
  • Chia-Chun Kuo,
  • Jen Chien Chien,
  • Koichi Haraikawa,
  • Maysam F. Abbod and
  • Jiann-Shing Shieh

25 October 2017

This study evaluates four databases from PhysioNet: The American Heart Association database (AHADB), Creighton University Ventricular Tachyarrhythmia database (CUDB), MIT-BIH Arrhythmia database (MITDB), and MIT-BIH Noise Stress Test database (NSTDB)...

  • Article
  • Open Access
14 Citations
8,793 Views
14 Pages

Design Techniques for Low-Power and Low-Voltage Bandgaps

  • Edoardo Barteselli,
  • Luca Sant,
  • Richard Gaggl and
  • Andrea Baschirotto

Reverse bandgaps generate PVT-independent reference voltages by means of the sums of pairs of currents over individual matched resistors: one (CTAT) current is proportional to VEB; the other one (PTAT) is proportional to VT (Thermal voltage). Design...

  • Article
  • Open Access
12 Citations
3,637 Views
10 Pages

29 April 2020

Microstructure and mechanical properties of Ti-6Al-4V/equine bone (EB) composites fabricated by ball milling and spark plasma sintering (SPS) have been investigated. Ti-6Al-4V/EB composites were successfully fabricated by a planetary ball-milling of...

  • Article
  • Open Access
5 Citations
4,613 Views
12 Pages

A 2.5 V, 2.56 ppm/°C Curvature-Compensated Bandgap Reference for High-Precision Monitoring Applications

  • Guangqian Zhu,
  • Zhaoshu Fu,
  • Tingting Liu,
  • Qidong Zhang and
  • Yintang Yang

18 March 2022

This work presents a high-precision high-order curvature-compensated bandgap voltage reference (BGR) for battery monitoring applications. The collector currents of bipolar junction transistor (BJT) pairs with different ratios and temperature characte...

  • Article
  • Open Access
909 Views
22 Pages

1 August 2025

This study investigates the engineering characteristics of a newly commissioned higher education building through the Bioharmological Conformity Assessment (BCA) method, specifically using the 2020vEB version. The BCA is a novel evaluation approach t...

  • Article
  • Open Access
11 Citations
3,054 Views
10 Pages

Analysis of Extended Spectrum Beta Lactamase (ESBL) Genes of Non-Invasive ESBL Enterobacterales in Southeast Austria in 2017

  • Astrid H. Paulitsch-Fuchs,
  • Nadine Melchior,
  • Theresa Haitzmann,
  • Theres Fingerhut,
  • Gebhard Feierl,
  • Rita Baumert,
  • Clemens Kittinger and
  • Gernot Zarfel

Extended spectrum beta lactamases producing Enterobacteriaceae are a major player in the antibiotic resistance challenge. In general, the situation regarding antibiotic resistance in Austria is very good compared to many other countries. Perhaps this...

  • Article
  • Open Access
12 Citations
2,902 Views
15 Pages

Presence and Persistence of ESKAPEE Bacteria before and after Hospital Wastewater Treatment

  • Miguel Galarde-López,
  • Maria Elena Velazquez-Meza,
  • Elizabeth Ernestina Godoy-Lozano,
  • Berta Alicia Carrillo-Quiroz,
  • Patricia Cornejo-Juárez,
  • Alejandro Sassoé-González,
  • Alfredo Ponce-de-León,
  • Pedro Saturno-Hernández and
  • Celia Mercedes Alpuche-Aranda

The metagenomic surveillance of antimicrobial resistance in wastewater has been suggested as a methodological tool to characterize the distribution, status, and trends of antibiotic-resistant bacteria. In this study, a cross-sectional collection of s...

  • Communication
  • Open Access
1 Citations
1,507 Views
9 Pages

The extended-spectrum β-lactamases (ESβLs) are bacterial enzymes capable of hydrolyzing penicillins, cephalosporins, and aztreonam. The prevalence of ESβL is increasing among clinically significant microorganisms worldwide, drastically...

  • Article
  • Open Access
39 Citations
6,202 Views
11 Pages

Multidrug-Resistant and Genetic Characterization of Extended-Spectrum Beta-Lactamase-Producing E. coli Recovered from Chickens and Humans in Egypt

  • Heba Badr,
  • Reem M. Reda,
  • Naglaa M. Hagag,
  • Essam Kamel,
  • Sara M. Elnomrosy,
  • Amal I. Mansour,
  • Momtaz A. Shahein,
  • Samah F. Ali and
  • Hala R. Ali

31 January 2022

Colonization of food chain animals such as chickens with extended-spectrum β-lactamases (ESBL) poses a major health threat to human. The current study aimed to determine the phenotypic and genotypic relationship between ESBL-producing E. coli fr...

  • Article
  • Open Access
10 Citations
3,326 Views
16 Pages

The Resistome of ESKAPEE Pathogens in Untreated and Treated Wastewater: A Polish Case Study

  • Jakub Hubeny,
  • Ewa Korzeniewska,
  • Sławomir Ciesielski,
  • Grażyna Płaza and
  • Monika Harnisz

21 August 2022

The aim of this study was to quantify ESKAPEE bacteria, genes encoding resistance to antibiotics targeting this group of pathogens, as well as integrase genes in municipal wastewater and river water. Environmental DNA was extracted from the collected...

  • Article
  • Open Access
48 Citations
6,532 Views
23 Pages

26 January 2023

Automated electrocardiogram (ECG) classification using machine learning (ML) is extensively utilized for arrhythmia detection. Contemporary ML algorithms are typically deployed on the cloud, which may not always meet the availability and privacy requ...

  • Article
  • Open Access
3 Citations
3,225 Views
20 Pages

The heterogenicity of antimicrobial resistance genes described in clinically significant bacterial isolates and their potential role in reducing the efficacy of classically effective antibiotics pose a major challenge for global healthcare, especiall...

  • Article
  • Open Access
10 Citations
5,442 Views
19 Pages

(1) Background: Beta-lactams are the most frequently used antimicrobials, and are the first-line drugs in many infectious diseases, e.g., pneumonia, otitis media. Due to this fact, various bacteria have developed resistance to this group of drugs. (2...

  • Communication
  • Open Access
11 Citations
3,055 Views
7 Pages

Diversity of Bacterial Clones and Plasmids of NDM-1 Producing Escherichia coli Clinical Isolates in Central Greece

  • Katerina Tsilipounidaki,
  • Zoi Florou,
  • Anargyros Skoulakis,
  • George C. Fthenakis,
  • Vivi Miriagou and
  • Efthymia Petinaki

The objective of the present study was to genetically characterize ten NDM-1 producing Escherichia coli isolates, recovered from patients in a hospital in Central Greece during the period 2017 to 2021.The isolates were studied by whole genome sequenc...

  • Article
  • Open Access
21 Citations
4,081 Views
15 Pages

Dissemination of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Serbian Hospital Settings: Expansion of ST235 and ST654 Clones

  • Jovana Kabic,
  • Gianuario Fortunato,
  • Ivone Vaz-Moreira,
  • Dusan Kekic,
  • Milos Jovicevic,
  • Jovan Pesovic,
  • Lazar Ranin,
  • Natasa Opavski,
  • Célia M. Manaia and
  • Ina Gajic

12 January 2023

This nationwide study aimed to investigate the molecular characteristics of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in Serbia, underlying resistance mechanisms, the genetic context of detected MBL genes, and the clonal relatio...

  • Article
  • Open Access
1,698 Views
23 Pages

Antibiotic Resistance, Virulence Genes, and Molecular Diversity of Clinical Klebsiella pneumoniae Isolates from Patients of District Hospital in Central Poland

  • Barbara Kot,
  • Małgorzata Witeska,
  • Piotr Szweda,
  • Małgorzata Piechota,
  • Elżbieta Kondera,
  • Elżbieta Horoszewicz,
  • Izabela Balak,
  • Ahmer Bin Hafeez and
  • Alicja Synowiec

In hospital environments, pathogenic bacteria spread easily and acquire virulence and antibiotic resistance genes. The aim of the study was an evaluation of the genetic diversity of 109 K. pneumoniae isolates recovered from patients of a district hos...

  • Article
  • Open Access
3,197 Views
15 Pages

Background/Objectives: The World Health Organization has recognized Pseudomonas aeruginosa as a multidrug-resistant bacterium that presents public health concerns. This study aimed to evaluate the prevalence of MDR P. aeruginosa isolates along with t...

  • Article
  • Open Access
13 Citations
3,037 Views
16 Pages

Monitoring of Non-β-Lactam Antibiotic Resistance-Associated Genes in ESBL Producing Enterobacterales Isolates

  • Pottathil Shinu,
  • Rajesh Bareja,
  • Anroop B. Nair,
  • Vashishth Mishra,
  • Snawar Hussain,
  • Katharigatta N. Venugopala,
  • Nagaraja Sreeharsha,
  • Mahesh Attimarad and
  • Sahibzada Tasleem Rasool

Genetic context of extended spectrum β-Lactamase (ESBL) producing Enterobacterales and its association with plasmid mediated quinolone resistance (PMQR), aminoglycoside modifying enzymes (AME) and Trimethoprim/Sulfamethoxazole (TMP-SMX) resistan...

  • Article
  • Open Access
5 Citations
2,435 Views
22 Pages

12 September 2020

The results of experimental studies of volume osmotic fluxes (Jvkr) and fluxes of dissolved substances (Jkr) in a system containing a synthetic Nephrophan® membrane (Orwo VEB Filmfabrik, Wolfen, Germany) set in a horizontal plane are presented. T...

  • Article
  • Open Access
46 Citations
83 Views

1 March 2018

Introduction: Pseudomonas aeruginosa is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This s...

  • Article
  • Open Access
4 Citations
10,673 Views
18 Pages

15 February 2023

The COVID-19 pandemic has had a significant impact on numerous industries, including the event industry, resulting in widespread disruptions. The widespread cancellations of festivals have been a direct consequence of the pandemic, and, following the...

  • Article
  • Open Access
21 Citations
4,734 Views
19 Pages

Antimicrobial Efficiency of Some Essential Oils in Antibiotic-Resistant Pseudomonas aeruginosa Isolates

  • Luc Tran Van,
  • Ilinca Hagiu,
  • Adelina Popovici,
  • Florica Marinescu,
  • Irina Gheorghe,
  • Carmen Curutiu,
  • Lia Mara Ditu,
  • Alina-Maria Holban,
  • Tatiana Eugenia Sesan and
  • Veronica Lazar

31 July 2022

Pseudomonas aeruginosa is a non-fermentative Gram-negative opportunistic pathogen, frequently encountered in difficult-to-treat hospital-acquired infections and also wastewaters. The natural resistance of this pathogen, together with the frequent occ...