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Antibiotics
Volume 14
Issue 6
10.3390/antibiotics14060567
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Article

First Report of High-Risk Carbapenem-Resistant K. pneumoniae ST307 Clone Producing KPC-2, SHV-106, CTX-M-15, and VEB-1 in Greece

by
Chatzidimitriou Maria
1,*,
Pandora Tsolakidou
2,
Kyriazidi Maria Anna
3,
Frydas S. Ilias
1,
Varlamis Sotiris
1,
Mavridou Maria
1 and
Mitka Stella
1
1
Department of Biomedical Sciences, International Hellenic University, 57400 Thessaloniki, Greece
2
Microbiology Department, Hospital of Volos, Polymeri 134, 38222 Volos, Greece
3
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Antibiotics 2025, 14(6), 567; https://doi.org/10.3390/antibiotics14060567 (registering DOI)
Submission received: 24 March 2025 / Revised: 24 May 2025 / Accepted: 29 May 2025 / Published: 31 May 2025
(This article belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)
Versions Notes

Abstract

Background/Objectives: Klebsiella pneumoniae ST307 is emerging as a significant global high-risk antimicrobial-resistant (AMR) clone with a notable capacity to acquire and disseminate resistance genes. However, there is limited research on the pathogenicity, virulence, and adaptation of ST307 strains and on the clinical characteristics of infected patients. Methods: In this study, a carbapenem-resistant K. pneumoniae (CRKP) ST307 strain named U989 was isolated from a urine culture of a hospitalized patient in Volos, Greece, in July 2024. Whole-genome sequencing was performed to identify resistance genes to β-lactams blaKPC-2, blaCTX-M-15, blaTEM-1B, blaOXA-1, blaOXA-10, blaSHV-106, and blaVEB-1 and resistance genes to other antibiotics. Results: A genomic analysis also revealed the presence of virulence factors such as iutA, clpK1, fyuA, fimH, mrkA, Irp2, and TraT and an IncFiB(pQil)/IncFII(K) replicon, which harbors the blaKPC-2 gene. Additionally, the transposable element Tn4401 was identified as a key vehicle for the mobilization of the blaKPC-2 resistance gene. Finally, this is the first report of a high-risk CRKP ST307 clone expressing KPC-2, SHV-106, CTX-M-15, and VEB-1 bla genes in Greece. Conclusions: The coexistence of these resistance genes in addition to aminoglycoside, quinolone, and other resistance genes results in difficult-to-treat infections caused by respective carrier strains, often requiring the use of last-resort antibiotics and contributing to the global challenge of antimicrobial resistance.
Keywords: K. pneumoniae; carbapenems; Greece; high-risk clone; ST307 K. pneumoniae; carbapenems; Greece; high-risk clone; ST307

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MDPI and ACS Style

Maria, C.; Tsolakidou, P.; Anna, K.M.; Ilias, F.S.; Sotiris, V.; Maria, M.; Stella, M. First Report of High-Risk Carbapenem-Resistant K. pneumoniae ST307 Clone Producing KPC-2, SHV-106, CTX-M-15, and VEB-1 in Greece. Antibiotics 2025, 14, 567. https://doi.org/10.3390/antibiotics14060567

AMA Style

Maria C, Tsolakidou P, Anna KM, Ilias FS, Sotiris V, Maria M, Stella M. First Report of High-Risk Carbapenem-Resistant K. pneumoniae ST307 Clone Producing KPC-2, SHV-106, CTX-M-15, and VEB-1 in Greece. Antibiotics. 2025; 14(6):567. https://doi.org/10.3390/antibiotics14060567

Chicago/Turabian Style

Maria, Chatzidimitriou, Pandora Tsolakidou, Kyriazidi Maria Anna, Frydas S. Ilias, Varlamis Sotiris, Mavridou Maria, and Mitka Stella. 2025. "First Report of High-Risk Carbapenem-Resistant K. pneumoniae ST307 Clone Producing KPC-2, SHV-106, CTX-M-15, and VEB-1 in Greece" Antibiotics 14, no. 6: 567. https://doi.org/10.3390/antibiotics14060567

APA Style

Maria, C., Tsolakidou, P., Anna, K. M., Ilias, F. S., Sotiris, V., Maria, M., & Stella, M. (2025). First Report of High-Risk Carbapenem-Resistant K. pneumoniae ST307 Clone Producing KPC-2, SHV-106, CTX-M-15, and VEB-1 in Greece. Antibiotics, 14(6), 567. https://doi.org/10.3390/antibiotics14060567

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