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35 Results Found

  • Article
  • Open Access
19 Citations
6,511 Views
12 Pages

Diets and Feeding Practices during the First 1000 Days Window in the Phnom Penh and North Eastern Districts of Cambodia

  • Somphos Vicheth Som,
  • Sophonneary Prak,
  • Arnaud Laillou,
  • Ludovic Gauthier,
  • Jacques Berger,
  • Etienne Poirot and
  • Frank T. Wieringa

18 April 2018

Although several health and development indicators have improved significantly in Cambodia, inadequate breastfeeding and inappropriate complementary feeding practices leave many children at high risk of malnutrition during the early stages of life. I...

  • Review
  • Open Access
70 Citations
13,277 Views
22 Pages

30 November 2016

Adequate supply of micronutrients during the first 1000 days is essential for normal development and healthy life. We aimed to investigate if interventions administering dietary doses up to the recommended nutrient intake (RNI) of iron and zinc withi...

  • Article
  • Open Access
8 Citations
4,783 Views
16 Pages

22 July 2022

This work provides a case study on the indoor environment and ventilation rate of naturally ventilated research student rooms in Chinese universities. In the measured room, air temperature, relative humidity and carbon dioxide (CO2) concentration wer...

  • Review
  • Open Access
280 Views
27 Pages

The First 1000 Days of PKU: A Narrative Review of Maternal PKU and Early Life Management After Positive Newborn Screening

  • Elvira Verduci,
  • Martina Tosi,
  • Juri Zuvadelli,
  • Sara Giorda,
  • Giacomo Biasucci,
  • Vincenzo Leuzzi,
  • Marco Spada,
  • Alberto Burlina and
  • Carlo Dionisi Vici

8 January 2026

Background/Objectives: The first 1000 days of life represent a critical window for growth and neurodevelopment, during which nutrition strongly influences brain development and metabolic programming. In phenylketonuria (PKU), dietary management is es...

  • Review
  • Open Access
67 Citations
8,889 Views
20 Pages

Intestinal ‘Infant-Type’ Bifidobacteria Mediate Immune System Development in the First 1000 Days of Life

  • Chunxiu Lin,
  • Yugui Lin,
  • Heng Zhang,
  • Gang Wang,
  • Jianxin Zhao,
  • Hao Zhang and
  • Wei Chen

2 April 2022

Immune system maturation begins early in life, but few studies have examined how early-life gut microbiota colonization educates the neonatal immune system. Bifidobacteria predominate in the intestines of breastfed infants and metabolize human milk o...

  • Article
  • Open Access
7 Citations
4,390 Views
16 Pages

Development of a Ventilation System Using Window Cavity

  • Jinuk Lee,
  • Sanghoon Park and
  • Taeyeon Kim

12 October 2020

A household unit of an existing apartment in which residents lived was selected, and the indoor air quality in each space of the unit was measured for analysis. Analysis of the measurement data indicated that the concentration of carbon dioxide (CO2)...

  • Article
  • Open Access
10 Citations
2,130 Views
20 Pages

Investigation of Microclimate Parameter Assurance in Schools with Natural Ventilation Systems

  • Tomas Makaveckas,
  • Raimondas Bliūdžius,
  • Sigita Alavočienė,
  • Valdas Paukštys and
  • Ingrida Brazionienė

Slow population growth has limited the construction of new schools, leading to the renovation of existing buildings to achieve energy efficiency goals. While improvements are made to thermal insulation, heating and ventilation systems often remain ou...

  • Review
  • Open Access
130 Citations
27,165 Views
33 Pages

Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis

  • Anna Ratsika,
  • Martin C. Codagnone,
  • Siobhain O’Mahony,
  • Catherine Stanton and
  • John F. Cryan

28 January 2021

Microbes colonize the human body during the first moments of life and coexist with the host throughout the lifespan. Intestinal microbiota and their metabolites aid in the programming of important bodily systems such as the immune and the central ner...

  • Perspective
  • Open Access
8 Citations
6,224 Views
10 Pages

Young Child Nutrition: Knowledge and Surveillance Gaps across the Spectrum of Feeding

  • Elizabeth J. Reverri,
  • Mary Beth Arensberg,
  • Robert D. Murray,
  • Kirk W. Kerr and
  • Karyn L. Wulf

28 July 2022

The first 1000 days is a critical window to optimize nutrition. Young children, particularly 12–24 month-olds, are an understudied population. Young children have unique nutrient needs and reach important developmental milestones when those nee...

  • Review
  • Open Access
22 Citations
6,398 Views
14 Pages

The First 1000 Days of Life: How Changes in the Microbiota Can Influence Food Allergy Onset in Children

  • Veronica Notarbartolo,
  • Maurizio Carta,
  • Salvatore Accomando and
  • Mario Giuffrè

16 September 2023

Background: Allergic disease, including food allergies (FA)s, has been identified as a major global disease. The first 1000 days of life can be a “window of opportunity” or a “window of susceptibility”, during which several fa...

  • Article
  • Open Access
631 Views
14 Pages

Limited Spectroscopy Data and Machine Learning for Detection of Zika Virus Infection in Aedes aegypti Mosquitoes

  • Leonardo Reigoto,
  • Rafael Maciel-de-Freitas,
  • Maggy T. Sikulu-Lord,
  • Gabriela A. Garcia,
  • Gabriel Araujo and
  • Amaro Lima

This study presents a technique for categorizing Aedes aegypti mosquitoes infected with the Zika virus under laboratory conditions. Our approach involves the utilization of the near-infrared spectroscopy technique and machine learning algorithms. The...

  • Article
  • Open Access
2 Citations
3,633 Views
11 Pages

Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period

  • Kristina Hase,
  • Laura Stahmer,
  • Hadeel Shammas,
  • Corinna Peter,
  • Bettina Bohnhorst and
  • Anibh Martin Das

Breast feeding is regarded as the preferred nutrition modality for children during the first few months of life. It not only furthers growth and development but also is supposed to impact later life. The first 1000 days are regarded as a critical win...

  • Review
  • Open Access
23 Citations
6,640 Views
12 Pages

From Birth to Weaning: A Window of Opportunity for Microbiota

  • Valentina Biagioli,
  • Greta Volpedo,
  • Antonella Riva,
  • Paolo Mainardi and
  • Pasquale Striano

17 January 2024

(1) Background: The first 1000 days of life constitute a critical window of opportunity for microbiota development. Nutrients play a crucial role in enriching and diversifying the microbiota, derived not only from solid food but also from maternal di...

  • Opinion
  • Open Access
145 Citations
21,220 Views
14 Pages

The prevalence of childhood overweight and obesity has increased in most countries the last decades. Considering this in a simplistic way, we can say that obesity is the result of an imbalance between energy intake and energy expenditure. Moreover, t...

  • Review
  • Open Access
26 Citations
10,815 Views
14 Pages

Baby-Led Weaning: What Role Does It Play in Obesity Risk during the First Years? A Systematic Review

  • Nazareth Martinón-Torres,
  • Nathalie Carreira,
  • Rosaura Picáns-Leis,
  • Alexandra Pérez-Ferreirós,
  • Anton Kalén and
  • Rosaura Leis

21 March 2021

Childhood is a window of opportunity for the prevention of the obesity pandemic. Since “the first 1000 days of life” is a period in which healthy eating habits must be acquired, it should be the target for preventive strategies. Baby-led weaning (BLW...

  • Review
  • Open Access
56 Citations
18,559 Views
32 Pages

Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift

  • Cristina Panisi,
  • Franca Rosa Guerini,
  • Provvidenza Maria Abruzzo,
  • Federico Balzola,
  • Pier Mario Biava,
  • Alessandra Bolotta,
  • Marco Brunero,
  • Ernesto Burgio,
  • Alberto Chiara and
  • Mario Clerici
  • + 25 authors

25 January 2021

The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogen...

  • Commentary
  • Open Access
523 Views
9 Pages

Thriving in the First 1000 Days: Lessons from Positive Deviance Among Young Families

  • Andrew P. Hills,
  • Sisitha Jayasinghe,
  • Kylie Mulcahy and
  • Nuala M. Byrne

The first 1000 days (F1D), from conception to a child’s second birthday, constitute a critical window for shaping long-term health, development, and wellbeing. While conventional approaches often rely on external interventions to support young...

  • Article
  • Open Access
2 Citations
3,348 Views
14 Pages

The first 1000 days represent a unique window of opportunity for second language learning. In two recent studies we demonstrated that Spanish infants’ use of second-language (L2) English productive vocabulary and early utterances rapidly increa...

  • Article
  • Open Access
6 Citations
3,506 Views
14 Pages

The first 1000 days of life seem to represent the temporal window of opportunity for modulating some of the risk factors associated with the later development of pathologies. Nonetheless, the dietary pattern and nutritional status of children receivi...

  • Article
  • Open Access
15 Citations
6,282 Views
17 Pages

The first 1000 days is a critical window of opportunity to promote healthy growth and associated behaviours. Health professionals can play an important role, in part due to the large number of routine contacts they have with parents. There is an abse...

  • Review
  • Open Access
34 Citations
7,763 Views
13 Pages

4 March 2022

The first 1000 days of life are very sensitive to any event that alters health programming, and they represent a window for intervention to improve population health. Pregnant women, fetuses, and infants are particularly vulnerable to exposure to foo...

  • Review
  • Open Access
87 Citations
10,015 Views
16 Pages

Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions

  • Alexandru Cosmin Pantazi,
  • Adriana Luminita Balasa,
  • Cristina Maria Mihai,
  • Tatiana Chisnoiu,
  • Vasile Valeriu Lupu,
  • Mustafa Ali Kassim Kassim,
  • Larisia Mihai,
  • Corina Elena Frecus,
  • Sergiu Ioachim Chirila and
  • Ancuta Lupu
  • + 4 authors

20 August 2023

The first 1000 days after birth represent a critical window for gut microbiome development, which is essential for immune system maturation and overall health. The gut microbiome undergoes major changes during this period due to shifts in diet and en...

  • Feature Paper
  • Review
  • Open Access
1 Citations
1,591 Views
16 Pages

The Silent Conquest: The Journey of Micro- and Nanoplastics Through Children’s Organs

  • Elena Esposito,
  • Francesco Fabrizio Comisi,
  • Vassilios Fanos and
  • Antonio Ragusa

24 September 2025

Micro- and nanoplastics (MNPs) are emerging environmental contaminants with increasing evidence of bioaccumulation in human tissues and potential toxicological effects. While extensive studies in the literature have investigated MNP exposure and heal...

  • Article
  • Open Access
13 Citations
4,510 Views
19 Pages

Profile of Small RNAs, vDNA Forms and Viral Integrations in Late Chikungunya Virus Infection of Aedes albopictus Mosquitoes

  • Michele Marconcini,
  • Elisa Pischedda,
  • Vincent Houé,
  • Umberto Palatini,
  • Nabor Lozada-Chávez,
  • Davide Sogliani,
  • Anna-Bella Failloux and
  • Mariangela Bonizzoni

25 March 2021

The Asian tiger mosquito Aedes albopictus is contributing to the (re)-emergence of Chikungunya virus (CHIKV). To gain insights into the molecular underpinning of viral persistence, which renders a mosquito a life-long vector, we coupled small RNA and...

  • Article
  • Open Access
90 Citations
11,576 Views
14 Pages

Over 70% of a pupil’s school life is spent inside a classroom, and indoor air quality has a significant impact on students’ attendance and learning potential. Therefore, the indoor air quality in primary school buildings is highly important. This emp...

  • Article
  • Open Access
1,384 Views
25 Pages

Effect of Gold Nanoparticles Against Tetranychus urticae and Phytoseiulus persimilis in Tomato

  • José Guadalupe Ontiveros-Guerra,
  • Sonia Noemí Ramírez-Barrón,
  • Luis Alberto Aguirre-Uribe,
  • Julio Cesar Chacón-Hernández,
  • Miriam Sánchez-Vega,
  • Ernesto Cerna-Chávez,
  • Josué Israel García-López,
  • Alberto Antonio Neira-Vielma,
  • Héctor Iván Meléndez-Ortiz and
  • Agustín Hernández-Juárez

12 July 2025

The two-spotted spider mite Tetranychus urticae Koch (Acari: Tetranychidae) is a major pest of horticultural, ornamental, fruit, and strawberry crops worldwide. Currently, various management tools have been explored for this pest, with nanoparticles...

  • Perspective
  • Open Access
8 Citations
6,345 Views
12 Pages

23 March 2018

Multiple drivers of the double burden of malnutrition (DBM) include a rapid shift from predominantly plant-based diets to energy-dense foods based on meats, milk, animal fats and vegetable oils. The shift to overweight and obesity is driven by increa...

  • Article
  • Open Access
870 Views
13 Pages

21 October 2025

Objectives: This study aims to evaluate the efficacy and safety of valproic acid (VPA) transition regimens (from intravenous to oral tablets) for anti-seizure treatment. Methods: A retrospective analysis was conducted on inpatients treated with intra...

  • Article
  • Open Access
11 Citations
2,276 Views
18 Pages

Structural Malformations in the Neonatal Rat Brain Accompany Developmental Exposure to Ammonium Perchlorate

  • Mary E. Gilbert,
  • Katherine L. O’Shaughnessy,
  • Kiersten S. Bell and
  • Jermaine L. Ford

18 December 2023

Environmental contaminants are often flagged as thyroid system disruptors due to their actions to reduce serum thyroxine (T4) in rodent models. The presence of a periventricular heterotopia (PVH), a brain malformation resulting from T4 insufficiency,...

  • Article
  • Open Access
11 Citations
3,500 Views
12 Pages

25 August 2022

The aim of the presented study was a comparative analysis of the polymerization kinetics of dental resin-based composites currently used in dentistry in different environmental conditions (irradiance, activation time, layer thickness). The photopolym...

  • Systematic Review
  • Open Access
1,281 Views
15 Pages

Continuous Wearable-Sensor Monitoring After Colorectal Surgery: A Systematic Review of Clinical Outcomes and Predictive Analytics

  • Calin Muntean,
  • Vasile Gaborean,
  • Alaviana Monique Faur,
  • Ionut Flaviu Faur,
  • Cătălin Prodan-Bărbulescu and
  • Catalin Vladut Ionut Feier

29 August 2025

Background and Objectives: Early ambulation and timely detection of postoperative complications are cornerstones of colorectal Enhanced Recovery After Surgery (ERAS) programmes, yet the traditional bedside checks performed every 4–8 h may miss...

  • Article
  • Open Access
881 Views
16 Pages

Maternal Overweight and Obesity Alter Neurodevelopmental Trajectories During the First Year of Life: Findings from the OBESO Cohort

  • Arturo Alejandro Canul-Euan,
  • Jonatan Alejandro Mendoza-Ortega,
  • Juan Mario Solis-Paredes,
  • Héctor Borboa-Olivares,
  • Sandra Martínez-Medina,
  • Carmen Hernández-Chávez,
  • Gabriela Gil-Martínez,
  • Erika Osorio-Valencia,
  • Mariana Torres-Calapiz and
  • Blanca Vianey Suárez-Rico
  • + 8 authors

14 October 2025

Background/Objectives: Overweight and obesity during pregnancy are metabolic risk factors that may compromise offspring brain development. The first 1000 days of life represent a critical window in which neurodevelopmental trajectories are shaped by...

  • Brief Report
  • Open Access
5 Citations
2,281 Views
8 Pages

Incorrect Feeding Practices, Dietary Diversity Determinants and Nutritional Status in Children Aged 6–23 Months: An Observational Study in Rural Angola

  • Andrea Pietravalle,
  • Alessia Dosi,
  • Telmo Ambrosio Inocêncio,
  • Francesco Cavallin,
  • Joaquim Tomás,
  • Giovanni Putoto and
  • Nicola Laforgia

30 November 2023

Background: More than a quarter of children who are affected by severe acute undernutrition reside in Sub-Saharan Africa. Incorrect feeding practices have a negative impact on a child’s health in both the short and the long term, and the interv...