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Vaccines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Research on Adenovirus-Vectored Vaccines

edited by

Michael A. Barry

and

Vijay S. Reddy

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2045 | Submission Open

Keywords: adenovirus; replication competent; single cycle; replication defective; serotypes; targeting; structure; cryo-EM; vaccines

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

COVID-19 Vaccines in the Post-Pandemic Era: Immune Responses, Boosting Strategies, and Long-Term Outcomes

edited by

Fabrizio Maggi

and

Licia Bordi

submission deadline 31 Mar 2027 | 3 articles | Viewed by 1866 | Submission Open

Keywords: COVID-19 vaccines; immune durability; booster strategies; long COVID

(This special issue belongs to the Section COVID-19 Vaccines and Vaccination)

The Changing Epidemiology of Vaccine-Preventable Diseases

edited by

Shuaiyin Chen

Yi-Han Lu

and

Yonghao Guo

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1853 | Submission Open

Keywords: vaccine-preventable diseases; epidemiology; vaccination; vaccine effectiveness; disease prevention; public health; real-world data

(This special issue belongs to the Section Epidemiology and Vaccination)

Next-Generation Vaccines Based on Recombinant Proteins, Antibodies and Nucleic Acids

edited by Devyani Joshi, Sanjeev Kumar and

Surabhi Gautam

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1288 | Submission Open

Keywords: monoclonal antibodies; recombinant scFv and nanobodies; immunotherapies; protein and nucleic acid based vaccines; mRNA and DNA-based therapeutics; next-generation immunization; antigen design; rational vaccine design

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

AI and Geospatial Modeling for Vaccination Strategies in LMICs

edited by Chigozie Edson Utazi, Justice Moses K. Aheto and Oghenebrume Wariri

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1212 | Submission Open

Keywords: routine immunization; supplementary immunization activities (SIAs); vaccination coverage; zero-dose children; disease incidence; geospatial data science; dynamic transmission modelling

Novel Adjuvants and Delivery Technologies for Vaccine Development

edited by

Mohammad N. Uddin

and

Bernadette D’Souza

submission deadline 31 Mar 2027 | 1 articles | Viewed by 884 | Submission Open

Keywords: adjuvants; vaccine delivery systems; immunogenicity; nanotechnology; clinical trials; antigen presentation; formulation development; vaccine efficacy; mucosal immunity

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

Vaccine Development and Global Health—2nd Edition

edited by

Krzysztof Kus

Karolina Hoffmann

and

Anna Paczkowska

submission deadline 31 Mar 2027 | Viewed by 515 | Submission Open

Keywords: next-generation vaccines; clinical efficacy of vaccines; vaccine safety; treatment methods for civilization diseases; public health; prevention of civilization diseases

(This special issue belongs to the Section Vaccines and Public Health)

Development of mRNA-Based Vaccines and Therapeutics

edited by Sushma M. Bhosle

submission deadline 31 Mar 2027 | Viewed by 361 | Submission Open

Keywords: mRNA design; immunotherapy; self-amplifying mRNA; adjuvants; lipid nanoparticles; mRNA engineering; complex in vitro platform; mRNA stability; immune response; clinical trials

(This special issue belongs to the Section Nucleic Acid (DNA and mRNA) Vaccines)

Hepatitis B Vaccinology in a Time of Rising Mortality: Advances in Preventive and Therapeutic Vaccine Innovation

edited by

Julio César Aguilar

and Osamu Yoshida

submission deadline 31 Mar 2027 | Viewed by 278 | Submission Open

Keywords: hepatitis B virus (HBV); preventive vaccines; therapeutic vaccines; functional cure; HBV immunology; viral hepatitis elimination; chronic HBV infection; immunotherapeutic strategies; birth‑dose and adult vaccination

(This special issue belongs to the Section Hepatitis Virus Vaccines)

The Surveillance and Longterm Impact of Rotavirus Vaccines and Associated Infections in Africa

edited by

Goitom Gebremedhin Weldegebriel

Duncan Steele

, Mapaseka L. Seheri and George Armah

submission deadline 31 Mar 2027 | 1 articles | Viewed by 252 | Submission Open

Keywords: rotavirus diarrhea; vaccine impact; global pediatric diarrhea surveillance; rotavirus genotypes

(This special issue belongs to the Section Epidemiology and Vaccination)

Recent Advances in Therapeutic Strategies for Zoonoses

edited by Xinyu Feng

submission deadline 31 Mar 2027 | Viewed by 53 | Submission Open

Keywords: zoonotic diseases; antimicrobial resistance; vaccine development; immunotherapeutics

(This special issue belongs to the Section Pathogens-Host Immune Boundaries)

Epidemiology and Public Health Surveillance for Vaccine-Preventable Diseases (VPDs)

edited by

Haiyan Yang

and

Dejian Liu

submission deadline 11 Apr 2027 | Viewed by 64 | Submission Open

Keywords: vaccine-preventable diseases; epidemiology; surveillance; transmission routes; vaccine development; control strategies

(This special issue belongs to the Section Epidemiology and Vaccination)

Pneumococcal Vaccines: Advances, Challenges, and Future Directions

edited by Michelle Darrieux

submission deadline 15 Apr 2027 | 1 articles | Viewed by 1856 | Submission Open

Keywords: Streptococcus pneumoniae; antimicrobial resistance (AMR); vaccination; pneumococcal conjugate vaccines (PCVs); serotype replacement; serotype-independent vaccines; protein antigens; reverse vaccinology; clinical trials; vaccine adjuvants

(This special issue belongs to the Section Vaccines Against Tropical and Other Infectious Diseases)

Next-Generation Recombinant Vaccines for Veterinary Infectious Diseases

edited by

Ravendra P. Chauhan

and

Boguslaw Szewczyk

submission deadline 15 Apr 2027 | Viewed by 293 | Submission Open

Keywords: veterinary; recombinant vaccines; viral vectors; mRNA vaccine; subunit vaccines; vaccine platforms

(This special issue belongs to the Section Veterinary Vaccines)

Evaluating Immunisation Programmes to Optimise Vaccination Strategies and Strengthen Vaccines Impact

edited by Irina Kislaya and Ausenda Machado

submission deadline 28 Apr 2027 | Viewed by 670 | Submission Open

Keywords: immunisation programme; impact; evaluation; implementation

(This special issue belongs to the Section Epidemiology and Vaccination)

Advances in HIV Vaccine Development, 2nd Edition

edited by

Xueling Wu

submission deadline 30 Apr 2027 | 4 articles | Viewed by 23646 | Submission Open

Keywords: HIV; envelope glycoprotein; vaccine; adjuvant; antibody; neutralization; ADCC; ADCP; complement; cellular immune response

(This special issue belongs to the Section HIV Vaccines)

Arboviral Infections (Dengue, Chikungunya, Zika, and Other Mosquito-Borne Diseases): Immune Response and Vaccine Development

edited by

Bo Peng

and Xiaolu Shi

submission deadline 30 Apr 2027 | 6 articles | Viewed by 8667 | Submission Open

Keywords: arbovirus; dengue virus; chikungunya virus; Zika virus; mosquito-borne disease; immune response; cross-immunity; antibody-dependent enhancement (ADE); vaccine development; immunopathology

(This special issue belongs to the Section Vaccines Against Tropical and Other Infectious Diseases)

New Challenges in Vaccines and Vaccination: A Public Health Perspective

edited by

Marcello Guido

and

Antonella Zizza

submission deadline 30 Apr 2027 | 6 articles | Viewed by 6776 | Submission Open

Keywords: vaccine effectiveness/efficacy; vaccination strategies; tailored approaches for different populations; public health

(This special issue belongs to the Section Vaccines and Public Health)

Viral Vector-Based Vaccines

edited by Marija Zaric, Hilary Whitworth and Arianna Marini

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3559 | Submission Open

Keywords: viral vectors; vaccines; immune response; vaccine platforms; vaccine development; vaccine production; vaccine delivery; vaccine safety; infectious disease; cancer vaccines; humoral immunity; cellular immunity; preclinical studies; clinical trials

Integrating Vaccination/Immunization Services into Universal Health Coverage

edited by

Anelisa Jaca

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3512 | Submission Open

Keywords: quality vaccination services; vaccine access; vaccination in universal health coverage (UHC)

(This special issue belongs to the Section Vaccines and Public Health)

Biotechnologies Applied in Vaccine Research: 2nd Edition

edited by

Yuan-Chuan Chen

submission deadline 30 Apr 2027 | 1 articles | Viewed by 3082 | Submission Open

Keywords: vaccine; biotechnology; vector; nanoparticle; virus; bacteria; recombination DNA; mRNA; subunit; adjuvant; delivery

Influenza Vaccines and Influenza Vaccination in Europe

edited by George Kassianos

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2762 | Submission Open

Keywords: vaccines; vaccine design; influenza; vaccination rates; vaccine efficacy; effectiveness; vaccine safety; vaccine development; adjuvant; recombinant influenza vaccine; cell-based; egg-derived; mRNA; vaccination strategies; vaccine response; antivirals

(This special issue belongs to the Section Influenza Virus Vaccines)

Immunization, Data Analytics, and Surveillance for Vaccine-Preventable Diseases (VPDs)

edited by

Shaodi Ma

and

Chenyu Sun

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1761 | Submission Open

Keywords: immunization programs; vaccine-preventable diseases (VPDs); real-world evidence; evidence-based medicine; AI and machine learning; vaccine safety and effectiveness; surveillance and early warning systems; public health policy and preparedness

(This special issue belongs to the Section Epidemiology and Vaccination)

Innovative Vaccines and Technologies to Address Tropical Parasitic Diseases

edited by

Cecilia Maria Perez Brandan

Iván Marcipar

and Fernando Sanchez-Valdez

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1576 | Submission Open

Keywords: tropical parasitic diseases; vaccine development; chimeric and multiepitope vaccines; immunomodulation and adjuvants; host–parasite interaction; biotechnology-based vaccine platforms

(This special issue belongs to the Section Vaccines Against Tropical and Other Infectious Diseases)

Rabies: Prevention, Vaccines, and One Health

edited by

Stephen J. Scholand

submission deadline 30 Apr 2027 | 1 articles | Viewed by 892 | Submission Open

Keywords: rabies; rabies vaccines; rabies immunization; One Health; rabies prevention; Zero by Thirty

(This special issue belongs to the Section Veterinary Vaccines)

The Advanced Research on Cancer Immunology

edited by Pasupathi Sundaramoorthy,

Naresh Poondla

and Cody C. Mchale

submission deadline 30 Apr 2027 | Viewed by 642 | Submission Open

Keywords: tumor microenvironment; immunosuppression; immune checkpoint inhibitors; adoptive cell transfer; cancer vaccines; immunotherapy resistance

(This special issue belongs to the Section Vaccination Against Cancer and Chronic Diseases)

Diphtheria-Tetanus-Pertussis (DTP) Vaccination Strategy

edited by Xiang Huo and

Xiang Sun

submission deadline 30 Apr 2027 | 1 articles | Viewed by 468 | Submission Open

Keywords: DTP vaccine; pertussis; vaccination strategy; immunogenicity; safety; antibody persistence; maternal immunization

(This special issue belongs to the Section Epidemiology and Vaccination)

Global Challenges Posed by Influenza: From Viral Genomics to Next-Generation Vaccine Technologies

edited by

Silvana Castaldi

and

Pier Mario Perrone

submission deadline 30 Apr 2027 | Viewed by 356 | Submission Open

Keywords: influenza vaccines; novel vaccine technology; vaccine effectiveness; immune responses; genomic epidemiology; mRNA vaccine; prophylactic viral vaccines; genomic medicine

(This special issue belongs to the Section Influenza Virus Vaccines)

Resurgence of Measles in the United States—Transmission Drivers, Dynamics, and Public Health Implications in Undervaccinated Clusters

edited by

M. Lelinneth (Len) B. Novilla

submission deadline 30 Apr 2027 | Viewed by 272 | Submission Open

Keywords: measles; measles resurgence; MMR vaccine; undervaccinated; vaccine hesitancy; vaccine misinformation; outbreak response; transmission dynamics; public health; public health surveillance; immunization policy; health equity

(This special issue belongs to the Section Vaccines and Public Health)

Vaccination in Pregnancy and Early Life: Evidence, Challenges, and Innovations

edited by Fani Ladomenou

submission deadline 15 May 2027 | 3 articles | Viewed by 4842 | Submission Open

Keywords: maternal immunization; infant vaccination; early‑life immunity; vaccine safety and effectiveness; vaccine hesitancy; perinatal health; immunization policy; public health interventions; implementation science

(This special issue belongs to the Section Vaccines and Public Health)

Vaccines Against Fish Diseases

edited by

Na Jiang

submission deadline 15 May 2027 | Viewed by 207 | Submission Open

Keywords: fish diseases; fish vaccines; aquaculture; vaccine development; recombinant vaccines; DNA/mRNA vaccines; vaccine delivery; immune response; pathogen; aquatic food security

(This special issue belongs to the Section Veterinary Vaccines)

Viral Vectored Vaccines: Design, Development, and Clinical Application

edited by Claire Powers and Dan Jones

submission deadline 28 May 2027 | Viewed by 88 | Submission Open

Keywords: viral vectored vaccines; antigen design and optimization; emerging and re-emerging pathogens; multivalent vaccines; vaccine manufacturing

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

Evaluation of Virus Vaccine Safety and Immune Response

edited by

Yang Zhang

, Guihong Yu and Lishan Sun

submission deadline 30 May 2027 | Viewed by 230 | Submission Open

Keywords: viral vaccine; vaccine safety; immune response; vaccine adjuvant; vaccine research method

(This special issue belongs to the Section Vaccine Advancement, Efficacy and Safety)

The Effectiveness of Influenza Vaccine

edited by Filippo Ansaldi and

Amicizia Daniela

submission deadline 31 May 2027 | 8 articles | Viewed by 17448 | Submission Open

Keywords: effectiveness; influenza vaccines; infection control; influenza vaccination; seasonal influenza vaccines

(This special issue belongs to the Section Influenza Virus Vaccines)

Therapeutic Cancer Vaccines: Advances, Challenges, and Future Directions

edited by Erminia Massarelli and Victoria M. Villaflor

submission deadline 31 May 2027 | 4 articles | Viewed by 6864 | Submission Open

Keywords: therapeutic cancer vaccines; clinical trials; solid tumors; malignant hematology; peptide vaccines; DNA vaccines; vector vaccines; dendritic cell vaccines; allogenic vaccines; mRNA vaccines

(This special issue belongs to the Section Vaccination Against Cancer and Chronic Diseases)

Strategies for Vaccination, Immunological Insights, Healthcare Advances, and Economic Outcomes in Health

edited by

Hai Fang

submission deadline 31 May 2027 | 3 articles | Viewed by 4903 | Submission Open

Keywords: vaccination; equity; disparities; vaccine coverage; vaccine economics

(This special issue belongs to the Section Vaccines and Public Health)

Next-Generation Platforms for Vaccine Design and Immune Evaluation

edited by Valentina Di Salvatore and

Giulia Russo

submission deadline 31 May 2027 | 2 articles | Viewed by 2971 | Submission Open

Keywords: vaccine design; mRNA vaccines; computational modeling; immunoinformatics; systems immunology; nanoparticle-based delivery; immunological evaluation

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

Epidemiology and Real-World Evidence to Inform Vaccine Design, De-Risk Development, and Maximize Real-World Impact

edited by Hilary Whitworth and Suzanna C. Francis

submission deadline 31 May 2027 | 3 articles | Viewed by 2367 | Submission Open

Keywords: epidemiology; real-world evidence; real-world data; vaccine development; R&D; immunoepidemiology; molecular epidemiology; pre-clinical development; clinical development; post-licensure

(This special issue belongs to the Section Epidemiology and Vaccination)

Bacterial Vaccines in Veterinary Science

edited by

Shenye Yu

submission deadline 31 May 2027 | 2 articles | Viewed by 2260 | Submission Open

Keywords: bacterial vaccine; animals; immune response; mucosal immunity; vaccine design

(This special issue belongs to the Section Veterinary Vaccines)

Research and Significance of Vaccines Against Sexually Transmitted Diseases

edited by

Angela Chia-Chen Chen

and Elizabeth Reifsnider

submission deadline 31 May 2027 | 1 articles | Viewed by 1941 | Submission Open

Keywords: sexually transmitted infections (STIs); HPV vaccine; hepatitis B vaccine; hepatitis A vaccine; vaccine uptake; interventions; equity in vaccination; preventive health

(This special issue belongs to the Section Vaccines and Public Health)

Anti-Parasitic Vaccines and Host Immune Responses

edited by

Fu-Shi Quan

submission deadline 31 May 2027 | 1 articles | Viewed by 1336 | Submission Open

Keywords: malaria; Leishmania donovani; Leishmania amazonensis; Toxoplasma gondii; Trichinella spiralis; Clonorchis sinensis

Skin Inflammation and Immunology: Vaccines, Immunomodulation, and Translational Therapeutics

edited by

Hong Zhou

Siyuan Chen

and Hazel H. Oon

submission deadline 31 May 2027 | 1 articles | Viewed by 640 | Submission Open

Keywords: skin vaccine; skin immunology; inflammatory skin diseases; immunomodulation; nanomedicine

(This special issue belongs to the Section Vaccines, Clinical Advancement, and Associated Immunology)

Precision Engineered mRNA Lipid Nanoparticles for Effective Immune Response

edited by

Sagar Salave

submission deadline 31 May 2027 | Viewed by 515 | Submission Open

Keywords: ionizable lipids; targeted delivery; immunomodulation; LNP architecture; mRNA vaccines

(This special issue belongs to the Section Nucleic Acid (DNA and mRNA) Vaccines)

Vaccines and Immunization Strategies for Healthcare-Associated Infections

edited by

Chenyuan Qin

and

Athanasios Tsakris

submission deadline 31 May 2027 | Viewed by 160 | Submission Open

Keywords: healthcare-associated infections; vaccines; immunization strategies; healthcare workers; antimicrobial resistance; infection prevention and control

Omics and Computational Strategies in Vaccine Safety: From Pharmacogenomics and Adverse Event Surveillance to Delivery System Modeling

edited by

Sher Singh

submission deadline 31 May 2027 | Viewed by 72 | Submission Open

Keywords: vaccine safety; pharmacogenomics; adverse events following immunization (AEFI); multi-omics; single-cell RNA sequencing; lipid nanoparticle; pharmacokinetics; vaccine-induced myocarditis; VITT; bioinformatics

(This special issue belongs to the Section Vaccine Advancement, Efficacy and Safety)

Pathogenesis and Vaccine Strategies for Emerging and Re-Emerging Viruses

edited by

Alberto Anastacio Amarilla

and

Christopher L. D. McMillan

submission deadline 15 Jun 2027 | Viewed by 161 | Submission Open

Keywords: emerging viruses; viral pathogenesis; vaccine development; pandemic preparedness; vaccine immunology and adjuvants

Innovations in Immunotherapy and Cancer Vaccines: From Bench to Bedside

edited by

Paul Takam Kamga

submission deadline 16 Jun 2027 | 1 articles | Viewed by 3681 | Submission Open

Keywords: cancer; immunotherapy; vaccine; preclinical and clinical studies

Evolution of Vaccinology and Immunization Decision-Making Processes

edited by

Benjamin Kagina

Carine Dochez

and

Elizabeth O. Oduwole

submission deadline 21 Jun 2027 | Viewed by 387 | Submission Open

Keywords: vaccinology; Evidence-to-Recommendation (EtR); NITAGs; immunization; AEFI; vaccine confidence; vaccine switches; immunization schedule optimization

(This special issue belongs to the Section Epidemiology and Vaccination)

Advances in Aquatic Animal Immunology and Vaccine Development for Disease Prevention

edited by Xiaohong Liu

submission deadline 30 Jun 2027 | 3 articles | Viewed by 5564 | Submission Open

Keywords: aquatic animal immunity; fish vaccines; crustacean and mollusk disease prevention; immune modulation in aquatic species; novel vaccine delivery systems in aquaculture; zoonotic disease prevention in aquatic animals

(This special issue belongs to the Section Veterinary Vaccines)

Global Immunization Inequities-Challenges and Solutions

edited by