African Swine Fever Virus Vaccine Development
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 203
Special Issue Editors
Interests: African swine fever virus; immune; immunotherapy; vaccine
Interests: African swine fever virus; ASFV vaccine; live vector vaccine
Interests: animal vaccines; molecular immunology; innate immunity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
African Swine Fever Virus (ASFV) is a large, enveloped double-stranded DNA virus. ASFV is a highly infectious and severe hemorrhagic disease that affects pigs, causing a wide range of clinical signs. ASFV has a case fatality rate of up to 100% in domestic pigs and wild boars. This outbreak has led to the deaths and culling of millions of pigs, posing a significant threat to the global pig industry. Fortunately, vaccines with good safety and efficacy have been developed and are being licensed for use in some countries. Although a vaccine that involves the deletion of virulent genes has been licensed in Vietnam and is used in specific local areas and limited farms, there are concerns about its biosafety. Issues such as homologous recombination, delayed onset, and the potential for secondary infections pose significant risks, and the performance of the gene-deleted live vaccine still requires further study. While inactivated vaccines, subunit vaccines, and vector-based ASF vaccines are generally considered safer, their efficacy is not enough to protect against higher doses of virulent viruses in inoculated infections.
We must investigate the changes that occur during viral infection and the resulting pathogenesis, while also focusing on vaccine research to provide a solid foundation for preventing and controlling ASF.
This Special Issue will explore the pathogenicity of and vaccines related to ASFV infection. We welcome original research articles and reviews on topics including (but not limited to) the following areas:
- Virus infection and dissemination;
- Pathogenicity, migratory patterns, tissue tropism, and distribution in pigs;
- Research on immune responses and the protective effects of various types of ASF vaccines.
We look forward to receiving your contributions.
Dr. Faming Miao
Dr. Hong Jia
Dr. Lian-Feng Li
Guest Editors
Manuscript Submission Information
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Keywords
- African swine fever virus
- infection and damage
- immune response
- vaccine
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