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Vaccines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Strategies to Boost the Immunogenicity of Cancer Vaccines

edited by Eric O'Neill and

Shisong Jiang

submission deadline 15 Jan 2027 | Viewed by 845 | Submission Open

Keywords: cancer vaccines; tumor antigens; tumor-associated antigens (TAAs); tumor-specific antigens (TSAs); subunit vaccines; peptide vaccines; mRNA vaccines; viral vector vaccines; adjuvants; antigen presentation; MHC class I and II upregulation; cancer immunotherapy; antibody–drug conjugates (ADCs); T cell engages; combination immunotherapy

Implementation Research for Strengthening Immunization Systems and Primary Health Care

edited by

Pedro Plans-Rubió

submission deadline 29 Jan 2027 | 1 articles | Viewed by 409 | Submission Open

Keywords: immunization equity; zero-dose children; immunization agenda 2030; health system strengthening; implementation research; LMICs; vaccination strategies; immunity levels; cost-effectiveness of vaccination programs

(This special issue belongs to the Section Vaccine Advancement, Efficacy and Safety)

Advancements in Vaccine Research: Epidemiology, Immunogenicity, Effectiveness and Safety

edited by

Chloé Dimeglio

submission deadline 31 Jan 2027 | 10 articles | Viewed by 24582 | Submission Open

Keywords: vaccine epidemiology; immune response; immunogenicity; vaccine effectiveness; safety; infectious diseases; public health; vaccine development; immunization strategies

(This special issue belongs to the Section Vaccine Advancement, Efficacy and Safety)

Challenges to Developing New Vaccines and Improving Existing Platforms

edited by

S. Louise Cosby

submission deadline 31 Jan 2027 | 10 articles | Viewed by 17426 | Submission Open

Keywords: infectious disease; cancer vaccines; humoral and cellular immunity; flaviviruses vaccines; inactivated and subunit vaccines; novel assays

Vaccine Design and Development

edited by

Vladimir Temchura

submission deadline 31 Jan 2027 | 7 articles | Viewed by 14424 | Submission Open

Keywords: vaccine design; vaccine development; vaccinology; immunization; immune response; vaccine delivery; vaccine efficacy

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

Cancer Vaccines: 4th Edition

edited by

So Young Yoo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 11055 | Submission Open

Keywords: cancer immunotherapy; therapeutic vaccine; tumor-associated antigens; neoantigens; adjuvant; tumor microenvironment; oncolytic viruses; immune checkpoint inhibitors

(This special issue belongs to the Section Vaccination Against Cancer and Chronic Diseases)

Chronic Viral Infections and Cancer: Openings for Vaccines and Cure

edited by

Maria G. Isaguliants

and Karl Ljungberg

submission deadline 31 Jan 2027 | 5 articles | Viewed by 8872 | Submission Open

Keywords: chronic viral infection; oncogenic viruses; hepatitis B virus; high risk human papillomaviruses; hepatitis C virus; epstein–barr virus; human immunodeficiency virus type I; cancer associated with viral infection; immunotherapy; prophylactic viral vaccines; therapeutic viral vaccines

Factors Influencing Vaccine Uptake and Immunization Outcomes

edited by Sitong Luo, Meiqi Xin and

Zixin Wang

submission deadline 31 Jan 2027 | 4 articles | Viewed by 6372 | Submission Open

Keywords: vaccination; vaccine uptake; immunization

(This special issue belongs to the Section Vaccines and Public Health)

Advancing Health: Vaccination and Infectious Disease Prevention in Pregnant Women, Neonates, Infants, and Children

edited by

Eleni Vergadi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 6262 | Submission Open

Keywords: infectious diseases; maternal immunization; pediatric infection control; immunization coverage; health equity; immunization strategies; vaccine safety

(This special issue belongs to the Section Vaccines and Public Health)

Antibodies in Autoimmune, Chronic, and Infectious Diseases: Pathogenic Mechanisms, Biomarkers, and Vaccine Development

edited by

Jorge Hernández-Bello

, Mariel García Chagollán and Francisco Javier Turrubiates Hernández

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5099 | Submission Open

Keywords: autoantibodies; monoclonal antibodies; chronic diseases; infectious diseases; autoimmune diseases; antibody-based vaccines; immunotherapy; antibody biomarkers; b cell response; translational immunology

(This special issue belongs to the Section Vaccines, Clinical Advancement, and Associated Immunology)

Nanoparticle-Based Delivery Systems for Vaccines

edited by

Sergio Rosales-Mendoza

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4295 | Submission Open

Keywords: virus-like particle; nanocage; chimeric antigen; mucosal vaccine; nanoadjuvant; nanoparticle

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

Antiviral Immunity and Vaccine Development

edited by

Caijun Sun

and Tao Yu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3525 | Submission Open

Keywords: antiviral innate immunity; adaptive immune responses; viral pathogenesis; immune evasion; host–virus interactions; antiviral vaccine development; vaccine design; novel vaccine platforms; vaccine adjuvants; vaccines and therapeutics

(This special issue belongs to the Section Pathogens-Host Immune Boundaries)

Immune Responses in Patients with Chronic Disease After Vaccination

edited by

Nikola Stojanović

and

Marko Baralic

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3255 | Submission Open

Keywords: immunity; vaccine; chronic kidney disease; glomerulonephritis; systemic lupus erythematosus; vasculitis; kidney transplant; schizophrenia; bipolar disorder; diabetes

(This special issue belongs to the Section Vaccines, Clinical Advancement, and Associated Immunology)

Closing Immunization Gaps: Coverage, Vaccine Uptake, and Evidence-Based Strategies in Global Public Health

edited by

Álvaro Francisco Lopes De Sousa

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2637 | Submission Open

Keywords: immunization coverage; vaccination uptake; vaccine hesitancy; immunization equity; implementation research; program evaluation; risk communication; public health policy

(This special issue belongs to the Section Vaccines and Public Health)

Genetically Engineered Mouse Models in Vaccine Development

edited by Deshan Ren and

Bingqian Qu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1663 | Submission Open

Keywords: vaccine; immunogenicity; knockout; knockin; transgenic mice; humanized mice; xenografts; NCG/NKG/NRG/NSG; viruses

(This special issue belongs to the Section Vaccines, Clinical Advancement, and Associated Immunology)

Immunity to Influenza Viruses and Vaccines: 2nd Edition

edited by

Rongbao Gao

submission deadline 31 Jan 2027 | 3 articles | Viewed by 1451 | Submission Open

Keywords: influenza; etiology; antiviral immunity; serology; vaccine; pathogenesis

(This special issue belongs to the Section Influenza Virus Vaccines)

RNA Vaccines: From Cancer to Infectious Diseases

edited by

Vrinda Gote

submission deadline 31 Jan 2027 | Viewed by 404 | Submission Open

Keywords: mRNA, saRNA, circularRNA vaccines; mRNA therapeutics; cancer immunotherapy; infectious disease vaccines; lipid nanoparticles (LNPs); nucleic acid delivery; vaccine formulation; innate immune activation; antigen design; nanocarrier systems; precision medicine

(This special issue belongs to the Section Nucleic Acid (DNA and mRNA) Vaccines)

Respiratory Virus Vaccines: Mechanisms of Durable Immunity and Innovation

edited by Jinyi Tang and Jinkai Zang

submission deadline 31 Jan 2027 | Viewed by 391 | Submission Open

Keywords: T cell immunity; mucosal immunology; respiratory virus infection; intranasal vaccination; tissue-resident memory T cells

(This special issue belongs to the Section Vaccines, Clinical Advancement, and Associated Immunology)

Vaccine Efficacy and Safety in Patients with Immune-Mediated Intestinal Diseases, 2nd Edition

edited by

Adi Lahat

and

Kassem Sharif

submission deadline 31 Jan 2027 | Viewed by 320 | Submission Open

Keywords: inflammatory bowel disease (IBD); Crohn’s disease; ulcerative colitis; celiac disease; vaccines; immune-mediated intestinal disease

(This special issue belongs to the Section Vaccine Advancement, Efficacy and Safety)

Innovations in Vaccine Technology—2nd Edition

edited by

Rachel Stephenson

submission deadline 1 Feb 2027 | Viewed by 285 | Submission Open

Keywords: inactivated vaccines; live-attenuated vaccines; messenger RNA (mRNA) vaccines; subunit, recombinant, polysaccharide and conjugate vaccines; toxoid vaccines; viral vector vaccines; personalized vaccines; antigen design; reverse vaccinology; lipid nanoparticles; cell-based vaccine production; virus-like particles

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

Advances, Challenges, and Future Perspectives in Vaccines for Vector-Borne Viruses

edited by

Ruiming Hu

and

Zheng Chen

submission deadline 10 Feb 2027 | Viewed by 251 | Submission Open

Keywords: vector-borne viruses; vaccine; adjuvant; immunity; attenuated vaccine; live vector vaccine; mRNA vaccine; recombinant subunit vaccine

(This special issue belongs to the Section Vaccines Against Tropical and Other Infectious Diseases)

Communicable Diseases: New and Old Therapies and Preventive Strategies, 2nd Edition

edited by

Cristina Genovese

Calimeri Sebastiano

, Daniela Lo Giudice,

Vincenza La Fauci

and

Vincenza Gianfredi

submission deadline 26 Feb 2027 | 6 articles | Viewed by 12796 | Submission Open

Keywords: vaccines; therapies; communicable diseases

Advances in Cancer Immunotherapy and Vaccines Research: 2nd Edition

edited by

Takumi Kumai

submission deadline 28 Feb 2027 | 10 articles | Viewed by 42526 | Submission Open

Keywords: tumor vaccine; immune adjuvants; tumor immune environment; peptide vaccine; chemoradiotherapy; cytokines; suppressive immune cells; checkpoint inhibitors

(This special issue belongs to the Section Vaccination Against Cancer and Chronic Diseases)

Advances in Rabies Vaccination

edited by Ye Feng,

Ming Zhou

and

Susan M. Moore

submission deadline 28 Feb 2027 | 2 articles | Viewed by 11546 | Submission Open

Keywords: rabies immunity; rabies vaccines; immunological mechanisms; correlates of protection; monoclonal antibodies; oral vaccination; vaccine delivery systems; post-exposure prophylaxis

(This special issue belongs to the Section Veterinary Vaccines)

BCG Vaccine and Beyond: Innovations in Tuberculosis Vaccination and Inflammation-Related Disease Prevention

edited by

Xiao-Yong Fan

and

Zhi-Dong Hu

submission deadline 28 Feb 2027 | 4 articles | Viewed by 8508 | Submission Open

Keywords: tuberculosis; vaccine; vaccination; immune response; adjuvant; T-cell; immune memory; adaptive immunity; innate immune memory; correlates of protection

(This special issue belongs to the Section Vaccines against Infectious Diseases)

Vaccine Development for Influenza Virus: 2nd Edition

edited by

Mingtao Zeng

and

Ganesh Yadaigiri

submission deadline 28 Feb 2027 | 6 articles | Viewed by 7721 | Submission Open

Keywords: influenza vaccine; adjuvant; mRNA vaccine; novel vaccine technology; nanotechnology; immune response; animal; human

(This special issue belongs to the Section Influenza Virus Vaccines)

Next-Generation Vaccine Platforms for Emerging Infections

edited by

Wangxue Chen

Xuguang Li

and

Amine A. Kamen

submission deadline 28 Feb 2027 | 4 articles | Viewed by 5160 | Submission Open

Keywords: nucleic acid vaccines; viral vector vaccines; nanoparticle-based immunogens; antigen design; adjuvants; novel delivery systems; manufacturing; AI

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

The Need for an HIV Vaccine in the Era of Highly Effective PrEP

edited by Michele Peake Andrasik, William O. Hahn and Susan P. Buchbinder

submission deadline 28 Feb 2027 | 4 articles | Viewed by 3947 | Submission Open

Keywords: HIV; vaccines; HIV prevention; bnAbs; clinical trials

(This special issue belongs to the Section HIV Vaccines)

Vaccine Advancement, Efficacy and Safety: Feature Papers

edited by

Pedro Plans-Rubió

submission deadline 28 Feb 2027 | 3 articles | Viewed by 3134 | Submission Open

Keywords: vaccine advancement; efficacy; effectiveness; vaccine platforms; vaccine development; immunity response; immunogenicity; cost-effectiveness; economic studies; vaccination strategies; clinical trials; cancer vaccines; vaccine access; performance of vaccination programs; quality of vaccination programs

(This special issue belongs to the Section Vaccine Advancement, Efficacy and Safety)

RBD-Based COVID-19 Vaccines: Technologies and Immune Responses

edited by Puthupparampil Scaria

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1776 | Submission Open

Keywords: RBD vaccine; COVID-19; vaccine; SARS-CoV-2

(This special issue belongs to the Section COVID-19 Vaccines and Vaccination)

Vaccines and Vaccination: HIV, Hepatitis Viruses, and HPV (2nd Edition)

edited by

Sonia Moretti

and

Ivan Schietroma

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1575 | Submission Open

Keywords: preventative vaccine; therapeutic vaccine; HIV; hepatitis A; hepatitis B; human papillomavirus; sexually transmitted infections; immunoprotection; vaccination; preventable diseases

Improving HPV Vaccination Coverage: Current Challenges, Emerging Strategies and Future Directions: 2nd Edition

edited by

Irena Ilic

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1228 | Submission Open

Keywords: HPV vaccination; HPV vaccination coverage; HPV vaccine uptake; single-dose HPV vaccination; gender-neutral HPV vaccination; HPV-related cancers; cervical cancer elimination; HPV vaccine hesitancy; HPV vaccine communication

(This special issue belongs to the Section Human Papillomavirus Vaccines)

Maternal Vaccination and Vaccines—2nd Edition

edited by

Gianluca Straface

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1094 | Submission Open

Keywords: prenatal care; vaccination; vaccination hesitancy; Tdap vaccine; influenza vaccine; COVID-19 vaccine

(This special issue belongs to the Section Vaccines and Public Health)

Pneumococcal Vaccine and Vaccination

edited by

Mark Hermannes Rozenbaum

submission deadline 28 Feb 2027 | 1 articles | Viewed by 754 | Submission Open

Keywords: pneumococcal conjugate vaccines; immunization programs; health technology assessment (HTA); cost-effectiveness analysis; disease transmission models (DTMs); antimicrobial resistance (AMR); number needed to vaccinate (NNV); pediatric and adult vaccination; global vaccine policy; reimbursement strategies; vaccine uptake and coverage; real-world evidence

Advances in Zoonoses and African Swine Fever Virus (ASFV) in China

edited by

Xiaokun Liu

and Qiang Zhang

submission deadline 28 Feb 2027 | Viewed by 610 | Submission Open

Keywords: infection; immunology; pathogenesis; antiviral compounds; vaccine

(This special issue belongs to the Section Pathogens-Host Immune Boundaries)

Vaccines Against Swine Respiratory Diseases

edited by Jairo Jaime

submission deadline 28 Feb 2027 | Viewed by 437 | Submission Open

Keywords: porcine respiratory disease complex (PRDC); vaccines; innate and adaptive immunity; viruses; bacteria; adjuvants; new vaccination strategies

(This special issue belongs to the Section Veterinary Vaccines)

Molecular Tuning for Vaccine Immunity: Regulating Immune and Inflammatory Responses to Inform Vaccine Design

edited by

Kiramage Chathuranga

and

Asela Weerawardhana

submission deadline 28 Feb 2027 | Viewed by 401 | Submission Open

Keywords: vaccine immunity; immune signaling pathways; inflammatory signaling; host–pathogen interactions; innate and adaptive immunity; post-translational modifications; immune regulation; cytokines and chemokines

(This special issue belongs to the Section Vaccine Design, Development, and Delivery)

Health Technology Assessment of Vaccination: Strategies, Public Health and Values: 2nd Edition

edited by Maarten J. Postma, Jurjen Van der Schans and

Cornelis Boersma

submission deadline 28 Feb 2027 | Viewed by 323 | Submission Open

Keywords: health technology assessment; population access vaccine studies; vaccination cost-effectiveness; vaccine hesitancy

(This special issue belongs to the Section Vaccines and Public Health)

Vaccines Against Bacterial Pathogens: Current Insights

edited by

Christopher Cote

, Kevin D. Mlynek and Sergei S. Biryukov

submission deadline 28 Feb 2027 | Viewed by 300 | Submission Open

Keywords: bacteria; vaccines; immune response; animal models; bacterial diseases

Vaccines Against Persistent Infections

edited by Hildegund C.J. Ertl

submission deadline 28 Feb 2027 | Viewed by 298 | Submission Open

Keywords: therapeutic vaccines; persistent infections; latent infections; chronic infections; viruses; bacteria; parasites; immune responses; adjuvants; checkpoint inhibitors

Effective Strategies for Boosting Vaccine Coverage

edited by

Claudio Fiorilla

Giovanna Elisa Calabrò

and

Fabio Massimo Contarino

submission deadline 5 Mar 2027 | 1 articles | Viewed by 1605 | Submission Open

Keywords: vaccine coverage; vaccine hesitancy; immunization strategies; public health; health communication; health systems; preventive medicine; vaccination programs; health equity; digital health

(This special issue belongs to the Section Vaccines and Public Health)

Vaccines for Tuberculosis Control

edited by

Subramanian Dhandayuthapani

and Chinnaswamy Jagannath

submission deadline 15 Mar 2027 | 1 articles | Viewed by 965 | Submission Open

Keywords: tuberculosis vaccine; recombinant vaccines; mRNA vaccines; viral vector vaccines; peptide vaccines; DNA vaccines; live-attenuated vaccines; immunology of adjuvants; immunoinformatics; multi-omics integration

(This special issue belongs to the Section Vaccines Against Tropical and Other Infectious Diseases)

Porcine Bacteria and Virus Vaccines

edited by Huixing Lin

submission deadline 15 Mar 2027 | Viewed by 851 | Submission Open

Keywords: Porcine; bacteria; virus; vaccine; diarrhea; dyspnea; adjuvant; attenuated vaccine; live vector vaccine; peptide vaccine

(This special issue belongs to the Section Veterinary Vaccines)

Epidemiology, Vaccines and Surveillance of COVID-19

edited by Chukwuma Mbaeyi,

Abdinoor Mohamed

and

Nishant Kishore

submission deadline 20 Mar 2027 | 3 articles | Viewed by 2658 | Submission Open

Keywords: COVID-19; coronavirus; SARS CoV-2; epidemiology; surveillance; case detection; vaccines; vaccinology

(This special issue belongs to the Section COVID-19 Vaccines and Vaccination)

Advances in Streptococcus pneumoniae Research: Host–Pathogen Interactions and Vaccine Development

edited by

James John

, Krupakar Parthasarathy and

Saqib Hassan

submission deadline 27 Mar 2027 | Viewed by 837 | Submission Open

Keywords: host immunity; bacterial colonization; immune evasion; virulence mechanisms; protein-based vaccines; pneumococcal disease; translational vaccine research

(This special issue belongs to the Section Pathogens-Host Immune Boundaries)

Vaccines and Immunization: Measles, Mumps, and Rubella

edited by Nobuhiko Okabe

submission deadline 31 Mar 2027 | 5 articles | Viewed by 10957 | Submission Open

Keywords: measles; mumps; rubella; SSPE; hearing loss; CRS; immune mechanism; epidemiology; resurgence; life-course immunization

(This special issue belongs to the Section Epidemiology and Vaccination)

Animal Infectious Diseases and Vaccinology in One Health

edited by

Edith Rojas-Anaya

and Elizabeth Loza-Rubio

submission deadline 31 Mar 2027 | 3 articles | Viewed by 6978 | Submission Open

Keywords: vaccinology; productive animals; one health; infectious diseases; zoonoses

(This special issue belongs to the Section Veterinary Vaccines)

mRNA Vaccines in Disease Prevention and Treatment

edited by

Jorge H. Leitão

submission deadline 31 Mar 2027 | 1 articles | Viewed by 6463 | Submission Open

Keywords: mRNA vaccines; viral infections; bacterial infections; parasitic infections; cancer treatment; vaccine delivery systems; immunological studies; adverse reactions

(This special issue belongs to the Section Nucleic Acid (DNA and mRNA) Vaccines)

Influenza Virus Infections, Vaccines and Diagnosis

edited by

Roberta Antonia Diotti

, Isabel Pagani and Valeria Caputo

submission deadline 31 Mar 2027 | 2 articles | Viewed by 4707 | Submission Open

Keywords: influenza; avian influenza; monoclonal antibodies; vaccine; therapy; infection

(This special issue belongs to the Section Influenza Virus Vaccines)

Factors Affecting and Strategies Enhancing the Willingness to Receive and Uptake of Seasonal Influenza Vaccination

edited by

Paul Shing-fong Chan

submission deadline 31 Mar 2027 | 3 articles | Viewed by 3770 | Submission Open

Keywords: factors; strategies; willingness; uptake; seasonal influenza vaccination

(This special issue belongs to the Section Vaccines and Public Health)

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