Nanoparticle-Based Delivery Systems for Vaccines

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Adjuvants".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 1364

Special Issue Editor


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Guest Editor
Biotechnology Section, Center for Research in Health Science and Biomedicine, Autonomous University of San Luis Potosí, Av. Sierra Leona 550, Lomas de San Luis, San Luis Potosí 78210, Mexico
Interests: adjuvant; multiepitope vaccine; humoral response; cellular response; recombinant vaccine; vaccinology; vaccine delivery vehicle
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Special Issue Information

Dear Colleagues,

Developing advanced vaccines is crucial for effectively combating human and animal diseases and improving global well-being. Nanotechnology has significantly enhanced vaccine design, resulting in innovative approaches such as virus-like particle (VLP)-based vaccines, RNA vaccines, and new adjuvants that boost vaccine efficacy.

This Special Issue aims to include advancements in vaccine efficacy achieved through nanomaterials to deliver protective antigens. It will also examine vaccine antigens with advantages such as easy purification and high immunogenicity. Additionally, the issue will explore nanomaterials used for alternative routes of administration, particularly those for mucosal vaccines, which hold promise for achieving protective immunity against various diseases. Furthermore, nanoparticles with immunostimulatory properties that can serve as vaccine adjuvants are also interesting.

We encourage original research articles and reviews covering research areas that may include antigen delivery using nanomaterials, nano-adjuvants, innovative vaccine antigens, and multifunctional nanoparticles.

We look forward to receiving your contributions.

Dr. Sergio Rosales-Mendoza
Guest Editor

Manuscript Submission Information

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Keywords

  • virus-like particle
  • nanocage
  • chimeric antigen
  • mucosal vaccine
  • nanoadjuvant
  • nanoparticle

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Published Papers (1 paper)

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Research

17 pages, 3847 KiB  
Article
Evaluation of Zein Nanoparticles as Delivery Agents of SARS-CoV-2 Antigens
by Verónica Araceli Márquez-Escobar, María José Alonso-Cerda, Sergio Rosales-Mendoza and María de Lourdes Betancourt-Mendiola
Vaccines 2025, 13(2), 139; https://doi.org/10.3390/vaccines13020139 - 28 Jan 2025
Viewed by 1019
Abstract
Background/Objectives: Nanovaccines have significant potential to enhance immunization strategies by improving efficacy, safety, and cost-effectiveness. In particular, organic nanoparticles hold promise for the generation of low-cost nanovaccines obtained by environmentally friendly methods. In this study, the feasibility of using zein nanoparticles (NPs) as [...] Read more.
Background/Objectives: Nanovaccines have significant potential to enhance immunization strategies by improving efficacy, safety, and cost-effectiveness. In particular, organic nanoparticles hold promise for the generation of low-cost nanovaccines obtained by environmentally friendly methods. In this study, the feasibility of using zein nanoparticles (NPs) as carriers for an antigenic peptide (p30) and the receptor binding domain (RBD) from SARS-CoV-2 spike protein was explored. Methods: A synthesis method for zein NPs was established by combining previously reported techniques, and the resulting NPs were characterized in terms of morphology, particle size, polydispersity index (PDI), surface charge, and colloidal stability using dynamic light scattering (DLS) and transmission electron microscopy (TEM). Tween 20 was employed as a surfactant to enhance particle stability and prevent aggregation. Results: The zein NPs were deemed safe based on an in vitro cytotoxicity assay using Vero cells. Immunogenicity assessments demonstrated that zein NPs:p30 and zein NPs:RBD induced IgG responses in test mice, whose magnitude was comparable to those achieved with alum as an adjuvant. Conclusions: These findings support the use of zein NPs as promising vaccine delivery vehicles with adjuvant effects due to their ease and environmentally friendly synthesis, high stability, and low cost. Full article
(This article belongs to the Special Issue Nanoparticle-Based Delivery Systems for Vaccines)
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