Development of Novel Mucosal Vaccines: Advances in Technology and Delivery

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Therapeutic Vaccines and Antibody Therapeutics".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1675

Special Issue Editor


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Guest Editor
Department of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA
Interests: vaccine development; autoimmunity; immunotherapy

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue, where we aim to focus on pathogens that invade the body through mucosal sites. Examples of this include oral and intranasal vaccination, which have emerged as promising approaches for mucosal vaccine delivery. Technological advancements in mucosal vaccination have heightened immunological responses, simplified administration, and enhanced efficacy. The primary objective of this Special Issue is to describe the latest technological developments that enable the effective delivery of vaccines, specifically focusing on mucosal vaccines and their development, production, processing, and design. Additionally, novel vaccine platforms for mucosal immunization, such as mRNA, DNA, viral vectors, live attenuated bacteria, bacterial vectors, and encapsulation techniques, are of interest.

We look forward to receiving your contributions.

Best regards,

Dr. Mohamed I. Husseiny El-Sayed
Guest Editor

Manuscript Submission Information

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Keywords

  • oral vaccines
  • nasal vaccines
  • live attenuated vaccines
  • DNA vaccines
  • mRNA vaccines
  • viral vectors vaccine
  • nanoparticle delivery system
  • adjuvants
  • gene-based vaccine
  • microencapsulation

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Published Papers (1 paper)

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Review

15 pages, 1187 KiB  
Review
Salmonella-Based Vaccine: A Promising Strategy for Type 1 Diabetes
by Mahmoud Singer, Fouad Kandeel and Mohamed I. Husseiny
Vaccines 2025, 13(4), 405; https://doi.org/10.3390/vaccines13040405 - 14 Apr 2025
Viewed by 940
Abstract
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the progressive destruction of insulin-producing β-cells in the pancreas. Currently, no therapy exists to halt or cure T1D. Vaccination with diabetic autoantigens may offer protection against T1D development. Genetically modified, attenuated Salmonella [...] Read more.
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the progressive destruction of insulin-producing β-cells in the pancreas. Currently, no therapy exists to halt or cure T1D. Vaccination with diabetic autoantigens may offer protection against T1D development. Genetically modified, attenuated Salmonella utilizing the Salmonella-Pathogenicity Island 2 (SPI2)-encoded Type Three Secretion System (T3SS) can elicit robust immune responses, making it an attractive vaccine platform. Using SPI2-T3SS to deliver an autoantigen alongside immunomodulators and anti-CD3 antibodies induces antigen-specific regulatory T-cells. Our preclinical studies demonstrated the efficacy of a Salmonella-based vaccine in both preventing and reversing autoimmune diabetes in non-obese diabetic (NOD) mice while also exploring its genetic modifications, underlying mechanisms, and delivery strategies. This review evaluates the advantages of an oral T1D vaccine employing live, attenuated Salmonella for autoantigen delivery. We also discuss future directions for advancing this strategy in the treatment of other autoimmune diseases. Full article
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