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Vaccines
Special Issues
Safety and Side Effects in SARS-CoV-2 Vaccine
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Safety and Side Effects in SARS-CoV-2 Vaccine

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Advancement, Efficacy and Safety".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 4148

Special Issue Editors

Dr. Ying-Fei Yang

E-Mail Website
Guest Editor
Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan
Interests: pharmacodynamics; infectious disease; epidemiological modeling; indoor control modeling of infectious disease
Special Issues, Collections and Topics in MDPI journals
Dr. Sher Singh

E-Mail Website
Guest Editor
Department of Life Science, School of Life Science, College of Science, National Taiwan Normal University, Taipei 11677, Taiwan
Interests: pharmacological; pharmacogenomics; bioinformatics

Special Issue Information

Dear Colleagues,

COVID-19 vaccines are important in the global battle against the SARS-CoV-2 pandemic. The swift development and distribution of COVID-19 vaccines, including mRNA (Pfizer-BioNTech, Moderna), viral vector (AstraZeneca, Johnson & Johnson, Sputnik V), and protein subunit (Novavax) vaccines, or inactivated virus (Sinovac, Sinopharm) vaccines, have been unprecedented. Although the benefits of vaccination in reducing COVID-19-induced illness and death are well documented, it is important to monitor and understand vaccines’ potential side effects. This Special Issue invites research papers and reviews that enhance current understanding of these vaccines' safety and side effects, focusing on special populations (e.g., the elderly and children, pregnant and lactating women, and immunocompromised individuals) and rare adverse events. Understanding these aspects is critical for healthcare providers and policymakers to improve vaccine confidence and optimize public health strategies. We also welcome articles on vaccine safety monitoring systems, e.g., the vaccine adverse event reporting system (VAERS) and the vaccine safety datalink (VSD). While these systems ensure ongoing assessment, it is essential to understand the effectiveness and transparency in different local or geographic regions. We look forward to receiving your research articles, including reviews, real-world data, meta-analyses, opinions, or surveys.

Dr. Ying-Fei Yang
Dr. Sher Singh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19 vaccine
  • vaccine adverse event reporting system (VAERS)
  • vaccine safety datalink (VSD)
  • adverse event
  • safety and side effects

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Published Papers (1 paper)

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9 pages, 5714 KiB  
Case Report
Rapid Progression of Cutaneous Lymphoma Following mRNA COVID-19 Vaccination: A Case Report and Pathogenetic Insights
by Berenika Olszewska, Anna Zaryczańska, Michał Bieńkowski, Roman J. Nowicki and Małgorzata Sokołowska-Wojdyło
Vaccines 2025, 13(7), 678; https://doi.org/10.3390/vaccines13070678 - 25 Jun 2025
Viewed by 3610
Abstract
Background: Reports of primary cutaneous lymphomas (CLs) following COVID-19 vaccines are extremely rare. Nevertheless, clinicians should be aware of a potential association between these events. Here, we report a case of the development and rapid progression of mycosis fungoides (MF) with lymph node [...] Read more.
Background: Reports of primary cutaneous lymphomas (CLs) following COVID-19 vaccines are extremely rare. Nevertheless, clinicians should be aware of a potential association between these events. Here, we report a case of the development and rapid progression of mycosis fungoides (MF) with lymph node involvement after COVID-19 vaccination. Case presentation: A 75-year-old female developed disseminated plaques and patches shortly after receiving the first dose of the SARS-CoV-2 mRNA vaccine. Within one month following the second dose of the mRNA vaccine, she additionally experienced rapid progression, leading to the development of tumors and inguinal lymphadenopathy. Blood and visceral involvement were excluded. The clinicopathological findings were consistent with the diagnosis of MF, and systemic methotrexate with topical treatment was implemented, resulting in remission of the lesions. Conclusions: The presented case of the development and rapid progression of MF after the SARS-CoV-2 mRNA vaccine raises the question of the possible immunomodulatory or oncomodulatory effects of mRNA vaccines. It prompted us to conduct a review outlining the mechanisms potentially causing the mRNA vaccine-associated CLs. We have performed an extensive literature search to determine an explanation for the observed phenomenon. Accumulated evidence suggests a link between CL occurrence and immunization with an mRNA vaccine. The proposed hypothesis revolves around shared signaling pathways that are enhanced by SARS-CoV-2 mRNA vaccines, thus driving the pathogenesis of MF. We want to raise clinicians’ attention to the rare side effects of COVID-19 vaccines and emphasize the need for thorough monitoring of patients with altered immunity in the course of various lymphoproliferative disorders. Full article
(This article belongs to the Special Issue Safety and Side Effects in SARS-CoV-2 Vaccine)
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