Vaccine and Vaccination in Veterinary Medicine

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 462

Special Issue Editors

Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Haping Street 678, Harbin 150069, China
Interests: vaccine; vaccinology; adjuvant; herpesvirus; equid; CRISPR/Cas9; molecular pathogenesis

E-Mail Website
Guest Editor
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
Interests: fish immune response; immune prevention of fish diseases; vaccines; adjuvants; immune enhancers; host–pathogen–environment interactions

Special Issue Information

Dear Colleagues,

Vaccine research is a fundamental aspect of modern animal health management, with significant implications for global food security, biodiversity conservation, and public health. The development and deployment of vaccines in veterinary medicine are crucial for controlling infectious diseases that threaten livestock, companion animals, and wildlife. These initiatives protect animal welfare and have direct implications for human health through the One Health paradigm, which emphasizes the interconnectedness of human, animal, and environmental ecosystems. Zoonotic pathogens, responsible for over 60% of emerging human infectious diseases, highlight the urgent need to control animal-borne infections. Vaccines not only reduce the risk of zoonotic spillover but also mitigate the economic losses resulting from outbreaks in agricultural systems, which can destabilize livelihoods and food supplies worldwide.

The scientific foundation of veterinary vaccinology has evolved significantly, driven by advances in immunology, genomics, and biotechnology. Traditional methods, such as live-attenuated or inactivated vaccines, have laid the groundwork for disease prevention but faced safety, efficacy, and scalability challenges. The advent of recombinant DNA technology has revolutionized the field by enabling targeted antigen design, improving immune responses, and reducing the risks associated with reversion to virulence. Innovations such as viral vector platforms, subunit vaccines, and mRNA-based formulations provide unprecedented precision in eliciting protective immunity.

Emerging challenges, however, require ongoing scientific innovation. Pathogen diversity, antimicrobial resistance, and climate-driven disease spread create a demand for vaccines that offer cross-protective and durable immunity. Diseases such as African swine fever, avian influenza, and peste des petits ruminants illustrate the gaps in vaccine coverage, particularly in resource-limited settings. Furthermore, the unique immunological needs of diverse species—from poultry to aquatic animals—necessitate tailored strategies. Collaborative frameworks integrating immunology, epidemiology, and data science are essential for addressing these complexities.

This Special Issue is a platform for disseminating cutting-edge research that bridges fundamental science and practical applications. We invite contributions in novel vaccine platforms (e.g., mRNA, viral vectors), mucosal immunization strategies, or cross-species immunity studies. We welcome original research articles, short communications, and reviews. Research areas include, but are not limited to, the following:

  • Vaccine safety and efficacy;
  • Establishment of infectious disease models in animals;
  • Development and design of novel or improved vaccines;
  • Differential diagnostics between vaccine administration and pathogen infection;
  • Therapeutic vaccines and vaccines for economic animals (e.g., foxes, deer, etc.);
  • Determining the relationship between veterinary vaccines and human health;
  • Vaccines and diagnostics for aquatic animals.

We look forward to receiving your contributions.

Dr. Diqiu Liu
Dr. Wen Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • veterinary vaccine
  • vaccine design
  • vaccine safety and efficacy
  • immune response
  • immunization

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 1632 KiB  
Article
Evaluation of the Potency of the First Commercial Vaccine for Clostridioides difficile Infection in Piglets and Comparison with the Humoral Response in Rabbits
by Victor Santos do Amarante, João Victor Ferreira Campos, Thayanne Gabryelle Viana de Souza, Yasmin Gonçalves de Castro, Kelly Mara Gomes Godoy and Rodrigo Otávio Silveira Silva
Vaccines 2025, 13(5), 438; https://doi.org/10.3390/vaccines13050438 - 22 Apr 2025
Viewed by 183
Abstract
Clostridioides difficile is an anaerobic bacterium that causes disease in both animals and humans. Despite the known significance of this agent, there are no commercial vaccines available for humans, and only one immunogen is marketed for swine. However, no studies have evaluated this [...] Read more.
Clostridioides difficile is an anaerobic bacterium that causes disease in both animals and humans. Despite the known significance of this agent, there are no commercial vaccines available for humans, and only one immunogen is marketed for swine. However, no studies have evaluated this vaccine. Background/Objectives: Therefore, the aim of this study was to assess the potency of the first commercial vaccine for C. difficile infection in piglets and to compare the humoral response in rabbits and sows. Methods: Pregnant sows were divided into two groups: a vaccinated group (n = 12), receiving two doses before farrowing, according to the manufacturer’s recommendation, and an unvaccinated control group (n = 6). Blood samples were taken from sows and also from piglets up to two days after birth. In addition, two groups of New Zealand rabbits (Oryctolagus cuniculus) received either a half-dose (G1) or a full-dose (G2) of the vaccine, with a control group receiving sterile saline (0.85%). Rabbits were vaccinated twice, 21 days apart, with blood samples collected before each dose and 14 days after the final dose. A serum neutralization assay in Vero cells was performed to evaluate the titers of neutralizing antibodies. Results: The vaccine demonstrated immunogenicity by stimulating the production of neutralizing antibodies in both rabbits and sows. Additionally, these antibodies were passively transferred to piglets through colostrum, reaching levels comparable to those found in sows. Furthermore, vaccinated rabbits developed antibody titers that do not significantly differ from those obtained in sows and piglets. Conclusions: The tested vaccine can induce a humoral immune response against C. difficile A/B toxins in sows and these antibodies are passively transferred to neonatal piglets through colostrum. Also, the vaccination of rabbits might be a useful alternative for evaluating the potency of vaccines against C. difficile. Full article
(This article belongs to the Special Issue Vaccine and Vaccination in Veterinary Medicine)
Show Figures

Figure 1

Back to TopTop