The Vaccine Development and Study of Swine Diseases

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 1060

Special Issue Editor


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Guest Editor
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Interests: swine disease control (especially PRRS control)
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Special Issue Information

Dear Colleagues,

Swine diseases faced in the pig farming process have severely threatened the safety and quality of pork products, seriously hindered the sustainable development of the pig farming industry, and posed a major risk to human health. For example, porcine reproductive and respiratory syndrome (PRRS) has become one of the most important pig diseases, causing huge economic losses worldwide. Vaccination and antiviral molecule treatment are the most effective strategies to combat pig diseases. However, several commercial vaccines provide limited protection against homologous strains such as PRRS vaccines or are unavailable (e.g., African swine fever). Therefore, novel swine vaccine development is urgently needed. The scope of this Special Issue focuses on developing novel swine vaccines, such as modified live vaccines, genetic engineering vaccines, and so on. The study of pathogen–host interactions for the design of vaccines is also encouraged.

Prof. Dr. Chunhe Guo
Guest Editor

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Keywords

  • swine diseases
  • viruses
  • vaccines
  • protection
  • control

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Published Papers (1 paper)

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Review

25 pages, 7343 KiB  
Review
Porcine Reproductive and Respiratory Syndrome Virus: Challenges and Advances in Vaccine Development
by Zhan He, Fangfang Li, Min Liu, Jiali Liao and Chunhe Guo
Vaccines 2025, 13(3), 260; https://doi.org/10.3390/vaccines13030260 - 28 Feb 2025
Viewed by 851
Abstract
Persistent infection of porcine reproductive and respiratory syndrome virus (PRRSV) significantly hampers both the quantity and quality of pork production in China. Although PRRSV is widely prevalent worldwide, the absence of effective vaccines has made it one of the major pathogens threatening the [...] Read more.
Persistent infection of porcine reproductive and respiratory syndrome virus (PRRSV) significantly hampers both the quantity and quality of pork production in China. Although PRRSV is widely prevalent worldwide, the absence of effective vaccines has made it one of the major pathogens threatening the sustainable development of the global swine industry. Vaccination remains one of the most effective measures for controlling pathogen infections. However, the continuous genetic recombination and mutation of PRRSV demand more comprehensive strategies to address emerging threats, while ensuring the efficacy and safety of vaccines. This review provides an overview of the latest advances in PRRSV vaccine research, highlighting the importance of understanding the unique strengths and limitations of various vaccines in developing effective therapeutic approaches and vaccination strategies. Moreover, the development of adjuvants and antiviral drugs as adjuncts to combat PRRSV infection offers significant potential for enhancing disease control efforts. With the advancement of technologies such as proteolysis-targeting chimera (PROTAC) and mRNA, new avenues for controlling PRRSV and other pathogens are emerging, offering considerable hope. Ultimately, the goal of these vaccine developments is to alleviate the impact of PRRSV on animal health and the profitability of the swine industry. Full article
(This article belongs to the Special Issue The Vaccine Development and Study of Swine Diseases)
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