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Vaccines
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Prevention of Human Papillomavirus (HPV) and Vaccination
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Prevention of Human Papillomavirus (HPV) and Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Human Papillomavirus Vaccines".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1904

Special Issue Editors

Dr. Sara Boccalini

E-Mail Website
Guest Editor
Department of Health Sciences, University of Florence, 50134 Florence, Italy
Interests: epidemiology and prevention of infectious diseases; health technology assessment (HTA) and pharmacoeconomic evaluations; seroepidemiology studies of vaccine-preventable infectious diseases; public health policies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Paolo Bonanni

E-Mail Website
Guest Editor
Department of Health Sciences, University of Florence, 50134 Florence, Italy
Interests: epidemiology and prevention of infectious diseases; health technology assessment of new vaccines and vaccination strategies; seroepidemiology studies of vaccine-preventable infectious diseases; public health policies
Special Issues, Collections and Topics in MDPI journals
Dr. Angela Bechini

E-Mail Website
Guest Editor
Department of Health Sciences, University of Florence, 50134 Florence, Italy
Interests: epidemiology and prevention of infectious diseases; surveillance of infectious diseases; seroepidemiology studies of vaccine-preventable infectious diseases; impact assessment of vaccination strategies in the general population and risk groups (healthcare workers, pregnant women, diabetic patients, asplenic patients, and adolescents)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human Papillomavirus (HPV) infection can result in cancers in both female and male populations, which could have been prevented by immunization. A secondary form of HPV cervical cancer prevention is also available. The WHO has set goals to reduce the average cervical cancer incidence rate by 10% by 2030, achieving 90% HPV vaccination coverage in girls, 70% screening coverage, and 90% coverage in terms of the treatment of precancerous lesions and invasive cancers. Different HPV vaccination and screening programs are in place worldwide. However, adherence to these preventive activities is frequently suboptimal, with some reports of vaccine hesitancy. The promotion of vaccination and screening is thus needed. Lastly, the assessment of the impact of immunization and screening could be useful to improve vaccination coverage.

This Special Issue aims to provide evidence regarding HPV vaccination and screening results and impact in different countries and settings (adolescents, healthy and treated women, men, MSM, etc.).

In this Special Issue, original research articles and reviews are welcome on research areas that may include (but are not limited to) the following: HPV genotype distribution in different pathologies according to age and sex, current and future HPV vaccination and screening strategies, efficacy and effectiveness of HPV vaccines in different target populations, measurement of HPV vaccination coverage, HPV vaccination after treatment, vaccine hesitancy, strategies to improve HPV vaccination and screening coverage in different target populations, cost-effectiveness of HPV vaccination and screening, and the use of potentially new and simplified diagnostic tests to evaluate preventive programs’ performance.

We look forward to receiving your contributions.

Dr. Sara Boccalini
Prof. Dr. Paolo Bonanni
Dr. Angela Bechini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV vaccination
  • screening
  • PAP test
  • HPV-DNA test
  • HPV vaccine coverage
  • vaccine hesitancy
  • promotion

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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27 pages, 819 KiB  
Review
HPV Vaccine Delivery Strategies to Reach Out-of-School Girls in Low- and Middle-Income Countries: A Narrative Review
by Erica N. Rosser, Megan D. Wysong, Joseph G. Rosen, Rupali J. Limaye and Soim Park
Vaccines 2025, 13(5), 433; https://doi.org/10.3390/vaccines13050433 - 22 Apr 2025
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Abstract
Background/Objectives: Low- and middle-income countries (LMICs) have the highest global burden of cervical cancer deaths. Human papillomavirus (HPV) vaccination is a key strategy for cervical cancer elimination, and in LMICs, global recommendations to vaccinate girls aged 9–14 years against HPV are generally implemented [...] Read more.
Background/Objectives: Low- and middle-income countries (LMICs) have the highest global burden of cervical cancer deaths. Human papillomavirus (HPV) vaccination is a key strategy for cervical cancer elimination, and in LMICs, global recommendations to vaccinate girls aged 9–14 years against HPV are generally implemented through school-based immunization platforms. Unfortunately, this strategy risks missing out-of-school (OOS) girls (i.e., girls not enrolled in formal schools). This narrative review maps the literature and synthesizes existing evidence on service delivery strategies for reaching OOS girls with HPV vaccination in LMICs. Methods: Using relevant databases, we conducted a narrative review of published, peer-reviewed literature to map and synthesize the existing evidence on effective service delivery strategies for reaching OOS girls with HPV vaccination in LMICs. Results: The 21 articles identified presented findings on strategies to reach OOS girls, with the most frequently cited strategies being facility-based and community outreach approaches. Authors also described community-based strategies used to identify and enumerate OOS girls, including peer tracing, church outreach initiatives, as well as partnerships with local groups (e.g., civil service organizations) and individuals (e.g., healthcare workers, teachers). The articles discussed barriers at the individual (e.g., lack of parental consent), facility/program delivery (e.g., lack of transportation for vaccines), and community (e.g., distance from homes to vaccination services) levels to HPV vaccine delivery, as well as solutions at the facility/program delivery (e.g., pilot programs) and community (e.g., multi-level partnerships) levels. Conclusions: Additional research is needed to evaluate implementation strategies targeting OOS girls with HPV vaccination. A better understanding of these strategies can provide valuable insights for HPV vaccine policymakers, healthcare providers, and program implementers. Full article
(This article belongs to the Special Issue Prevention of Human Papillomavirus (HPV) and Vaccination)
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Other

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10 pages, 1818 KiB  
Viewpoint
Human Papilloma Virus Vaccination as a Strategy to Eliminate Cervical Cancer: Challenges and Opportunities
by Maria L. Avila-Aguero, Sebastian Ospina-Henao, Helena Brenes-Chacon, Carlos Espinal-Tejada, Ruby Trejo-Varon and Ana Morice
Vaccines 2025, 13(3), 297; https://doi.org/10.3390/vaccines13030297 - 11 Mar 2025
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Abstract
In August 2020, the World Health Assembly approved the global strategy to eliminate cervical cancer, envisioning a world where it seizes to be a public health problem. The cervical cancer elimination initiative reinforces the commitment to fulfilling the rights of adolescent girls and [...] Read more.
In August 2020, the World Health Assembly approved the global strategy to eliminate cervical cancer, envisioning a world where it seizes to be a public health problem. The cervical cancer elimination initiative reinforces the commitment to fulfilling the rights of adolescent girls and women by reducing both health and economic inequities in the poorest populations that have more limited access to timely and effective services. This initiative improves the quality of life of women and their families by protecting them from a disease that causes disability and preventing avoidable mortality through public health measures. This article discusses the epidemiological situation and vaccination coverage and identifies weaknesses and opportunities in Latin America and the Caribbean to propose actions to reinforce progress toward the cervical cancer elimination goal. Full article
(This article belongs to the Special Issue Prevention of Human Papillomavirus (HPV) and Vaccination)
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