Vaccine Strategies for HPV-Related Cancers: 2nd Edition

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Human Papillomavirus Vaccines".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 807

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Guest Editor
Departments of Family Medicine and Obstetrics & Gynecology, University of Michigan, Ann Arbor, MI, USA
Interests: HPV associated diseases; cervical cancer; screening; prevention; vaccines
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Dear Colleagues,

Human papillomavirus (HPV) vaccines were purposefully designed to cover HPV 16 and 18, which are associated with about 70% of cervical cancers, and about 90% of the HPV-associated head and neck and anal cancers. Enough time has elapsed to see early indicators of the reduction in cancers associated with HPV. Other types of HPV will be clinically unmasked as the natural infection types are blocked. The change in the distribution of the HPV types causing the associated cancers will be important to note so that modeling studies for future prognostic health planning can be modified. HPV vaccine administration appears to be sufficient at one dose for children 9 years of age. Increasing population coverage with a single dose offers more efficiency and equity in vaccine distribution. Understanding person-level and population-level barriers and facilitators to the original vaccine uptake is needed. Separately, the development of pan-HPV vaccines as the next-generation vaccine is imperative. Continuing to leave oncogenic HPV types out of the vaccine perpetuates HPV-associated cancer inequities.

Prof. Dr. Diane M. Harper
Guest Editor

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Keywords

  • HPV vaccine uptake
  • single dose immunization
  • clinical unmasking
  • HPV-associated cancers

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Published Papers (1 paper)

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Research

14 pages, 2858 KiB  
Communication
Vaccine Confidence During Public Health Challenges and Prior to HPV Vaccine Introduction in Mali
by Tiffani Crippin, Karamoko Tounkara, Ibrahima Diarra, Pierre Kamate, Sarah Beseme, Matthew Murphy, Hayley Munir, Amalle Keita Daou, Garan Dabo, Ibrahima Téguété, Ousmane Koita and Anne S. De Groot
Vaccines 2025, 13(5), 535; https://doi.org/10.3390/vaccines13050535 - 17 May 2025
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Abstract
Background/Objectives: Public health activities and the roll-out of new vaccines such as the HPV vaccine in Mali have been disrupted by both the COVID-19 pandemic and by political unrest from March 2020 until recently. The HPV vaccine was introduced into the childhood [...] Read more.
Background/Objectives: Public health activities and the roll-out of new vaccines such as the HPV vaccine in Mali have been disrupted by both the COVID-19 pandemic and by political unrest from March 2020 until recently. The HPV vaccine was introduced into the childhood vaccine program in 2024. Given the persistent threat of ongoing infectious disease epidemics, there is a pressing need to understand the factors influencing vaccine uptake in Mali and other low- and middle-income countries. Methods: To address this need, the GAIA Vaccine Foundation (GAIA VF), a nongovernmental organization (NGO), conducted a study of vaccine confidence in Bamako, the country’s capital and primary population center, between September 2021 and March 2022 at 12 community based primary care clinics and 1 rural primary care clinic. The study was coupled with a vaccine outreach and education campaign at each site. Results: Study staff collected information on vaccine confidence in surveys from 3445 community participants. Healthcare providers were also recruited from the 13 sites for vaccine-related training, and 140 of these participants completed pre- and post-surveys on their vaccine knowledge and confidence. Survey results indicate that community members trust their primary care providers more than they trust the government. However, primary care providers trust government sources of information more than other sources for guidance on vaccines. Conclusions: As new vaccines are introduced, engaging key healthcare leaders to inform healthcare providers and developing primary care provider-led community outreach will be critically important to gaining community confidence prior to and during vaccination campaigns in the future. Full article
(This article belongs to the Special Issue Vaccine Strategies for HPV-Related Cancers: 2nd Edition)
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