The Development of Vaccine Against Parasite Infection

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Tropical and other Infectious Diseases".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1157

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Guest Editor
National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Interests: immunology; vaccines; tropical diseases; protozoa; helminths; neglected tropical diseases; one health; comparative medicine
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Special Issue Information

Dear Colleagues,

Parasitic infections affect over three billion people worldwide, leading to significant morbidity and mortality. For over 100 years, the mass administration of anti-parasitic drugs, combined with improved vector control and sanitation measures, has significantly reduced infections, leading to improved health outcomes. However, the rising incidence of anti-parasitic medicines and insecticide resistance threaten the effectiveness of these measures. Vaccines have been used to prevent infections and reduce the burden of disease for over 200 years; however, the only antiparasitic vaccine licensed for clinical use is the RTS, S/AS01 malaria. Therefore, there is an urgent to develop vaccines that target parasitic infections. This Special Issue will focus on several factors that affect the development of vaccines for parasitic diseases, including needs assessments, novel vaccine candidates, adjuvant and delivery system technologies that enhance development strategies, and reviews providing an overview of the current status of the field.

Dr. Kathryn M. Jones
Guest Editor

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Keywords

  • adaptive immune response
  • vaccine
  • adjuvant
  • protozoal
  • helminth
  • apicomplexan
  • delivery systems
  • epidemiology
  • needs assessment

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Published Papers (1 paper)

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Research

23 pages, 2715 KiB  
Article
The Sm14+GLA-SE Recombinant Vaccine Against Schistosoma mansoni and S. haematobium in Adults and School Children: Phase II Clinical Trials in West Africa
by Amadou Tidjani Ly, Doudou Diop, Modou Diop, Anne-Marie Schacht, Abdoulaye Mbengue, Rokhaya Diagne, Marieme Guisse, Jean-Pierre Dompnier, Carolina Messias, Rhea N. Coler, Celso R. Ramos, Jacques-Noël Tendeng, Seynabou Ndiaye, Miryam Marroquin-Quelopana, Juçara de Carvalho Parra, Tatiane dos Santos, Marília Sirianni dos Santos Almeida, Daniella Arêas Mendes-da-Cruz, Steven Reed, Wilson Savino, Gilles Riveau and Miriam Tendleradd Show full author list remove Hide full author list
Vaccines 2025, 13(3), 316; https://doi.org/10.3390/vaccines13030316 - 16 Mar 2025
Viewed by 817
Abstract
Background/Objectives: Following previous successful Phase I clinical trials conducted in men and women in a non-endemic area for schistosomiasis in Brazil, the Sm14 vaccine was evaluated in an endemic region in Senegal. We report successful clinical trials in adults (Phase IIa) and school [...] Read more.
Background/Objectives: Following previous successful Phase I clinical trials conducted in men and women in a non-endemic area for schistosomiasis in Brazil, the Sm14 vaccine was evaluated in an endemic region in Senegal. We report successful clinical trials in adults (Phase IIa) and school children (Phase IIb), respectively, of a Schistosoma mansoni 14 kDa fatty acid-binding protein (Sm14) vaccine + a glucopyranosyl lipid A (GLA-SE) adjuvant. Methods: Participants were evaluated based on clinical assessments, laboratory tests (including hematologic and biochemical analyses of renal and hepatic functions), and immunological parameters (humoral and cellular responses) up to 12 months after the first vaccination dose in the Phase IIa trial and after 120 days in the Phase IIb trial. Results: The results showed strong immunogenic responses and good tolerance in both adults and children, with no major adverse effects. Importantly, significant increases in Sm14-specific total IgG (IgG1 and IgG3) were observed as early as 30 days after the first vaccination, with high titres remaining at least 120 days afterwards. Sm14-specific total IgG serum levels were also significantly enhanced in adults and in both infected and non-infected, vaccinated children and elicited robust cytokine responses with increased TNFα, IFN-γ, and IL-2 profiles. Conclusions: Overall, the Sm14+GLA-SE vaccine is safe and highly immunogenic, with a clearly protective potential against schistosomiasis, supporting progression to the next Phase III clinical trials. Full article
(This article belongs to the Special Issue The Development of Vaccine Against Parasite Infection)
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