Vaccination or Infection and the Role of T Cells—the Response to Cancer, Autoimmunity or Inflammatory Diseases

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cancer Vaccines and Immunotherapy".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 861

Special Issue Editor


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Guest Editor
NHC Key Laboratory of Medical Immunology, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China
Interests: inflammation and immune regulation; T-cell immunology; adrenergic α2 receptors; anesthesia and immune modulation; anti-infective immunity

Special Issue Information

Dear Colleagues,

The roles of T cells in cancer, autoimmune, and inflammatory diseases represent an area of rapidly advancing research, providing crucial insights into immune regulation and disease development. T cells play a key role in regulating immune responses and orchestrating immune reactions through their various subpopulations and adaptable functions. In cancer, T cells can promote anti-tumor immunity, but they can also contribute to tumor immune evasion and resistance to immunotherapy. In autoimmune and inflammatory diseases, imbalanced T-cell responses can lead to persistent inflammation and tissue damage. Understanding the mechanisms behind T-cell function and dysfunction is critical for developing targeted therapies that regulate T-cell activity, offering promising approaches for treating a range of diseases.

For this Special Issue, we request original research, reviews, and studies that deepen our understanding of T-cell biology, their roles in disease, and innovative therapeutic strategies targeting T cells.

Prof. Dr. Yuedan Wang
Guest Editor

Manuscript Submission Information

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Keywords

  • T-cell biology
  • cancer immunotherapy
  • autoimmune diseases
  • inflammatory diseases
  • immune modulation

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Published Papers (1 paper)

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Review

21 pages, 2202 KiB  
Review
CAR Beyond αβ T Cells: Unleashing NK Cells, Macrophages, and γδ T Lymphocytes Against Solid Tumors
by Yunjia Xian and Lu Wen
Vaccines 2025, 13(6), 654; https://doi.org/10.3390/vaccines13060654 - 19 Jun 2025
Viewed by 483
Abstract
Chimeric antigen receptor (CAR)-engineered cell therapy represents a landmark advancement in cancer immunotherapy. While αβ CAR-T therapy has demonstrated remarkable success in hematological malignancies, its efficacy in solid tumors remains constrained mainly by factors such as antigen heterogeneity, immunosuppressive microenvironments, and on-target/off-tumor toxicity. [...] Read more.
Chimeric antigen receptor (CAR)-engineered cell therapy represents a landmark advancement in cancer immunotherapy. While αβ CAR-T therapy has demonstrated remarkable success in hematological malignancies, its efficacy in solid tumors remains constrained mainly by factors such as antigen heterogeneity, immunosuppressive microenvironments, and on-target/off-tumor toxicity. To overcome these limitations, emerging CAR platforms that utilize alternative immune effectors, including natural killer (NK) cells, macrophages, and γδ T lymphocytes, are rapidly gaining traction. This review systematically analyzes the mechanistic advantages of CAR-NK, CAR-M, and CAR-γδ T cell therapies, while critically evaluating persistent challenges in clinical translation, including limited cell persistence, manufacturing scalability, and dynamic immune evasion mechanisms. We further discuss innovative strategies to enhance therapeutic efficacy through some viable strategies. By bridging fundamental immunology with translational engineering, this work provides a roadmap for developing CAR therapies capable of addressing the complexities of solid tumor eradication. Full article
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