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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Molecular Cargo of Extracellular Vesicles: A Key to Understanding Their Biological Role

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 31 Mar 2026 | 3 articles | Viewed by 4100 | Submission Open

Keywords: extracellular vesicles (EVs); intercellular communication; molecular cargo; proteins in EVs; lipids in EVs; metabolites in EVs; nucleic acids in EVs; horizontal gene transfer; bioactive molecules in EVs

(This special issue belongs to the Section Cell Metabolism)

Mass Spectrometry-Based Technology for Metabolic Profiling

edited by Gregory Hamm,

Laura Cole

and Lin Wang

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3051 | Submission Open

Keywords: metabolomics; lipidomic; high-resolution mass spectrometry; untargeted and targeted; data processing; pathway mapping; fluxomic

(This special issue belongs to the Section Metabolomic Profiling Technology)

Climate Change-Related Stresses and Plant Metabolism

edited by

Eva Collakova

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2752 | Submission Open

Keywords: plant physiology and metabolism; climate change-related stresses; multi-omics approaches; plant stress phenotyping; crop improvement

(This special issue belongs to the Section Plant Metabolism)

The Impact of Environmental Contaminants on Neurodevelopment and Human Metabolism

edited by

Cláudia Sirlene Oliveira

and

Izonete Cristina Guiloski

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2736 | Submission Open

Keywords: pesticides; metals; mercury; methylmercury; developing organism; oxidative stress

(This special issue belongs to the Section Environmental Metabolomics)

Metabolomics Insights into Environmental Pollution: Unraveling Metabolic Responses to Contaminants

edited by

Dechun Chen

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2565 | Submission Open

Keywords: metabolomics; environmental contaminants; biomarkers; toxicity mechanisms; metabolic alterations; ecological health; human health; cellular metabolism; organismal metabolism; pollution mitigation strategies

(This special issue belongs to the Section Environmental Metabolomics)

Metabolic Signatures in Human Health and Disease

edited by Samantha Lodge

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1704 | Submission Open

Keywords: inflammation; disease biomarkers; metabolomic health; healthy ageing; obesity; chronic disease; metabolic phenotyping

(This special issue belongs to the Section Integrative Metabolomics)

New Insights into Microalgae Metabolism

edited by Wei Ding and

Yongteng Zhao

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1598 | Submission Open

Keywords: microalgae metabolism; carbon fixation; lipids; high-value compounds; synthetic biology; stress responses

(This special issue belongs to the Section Food Metabolomics)

Machine Learning Applications in Metabolomics Analysis: 2nd Edition

edited by

Leonardo Franco

and

Martin Grootveld

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1403 | Submission Open

Keywords: metabolites; biofluids; artificial intelligence; metabolomics; machine learning

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Nutritional Intervention and Metabolic Health: Multi-Omics Insights

edited by

Qingqing Mao

Yuyin Zhou

and

Hongming Su

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1110 | Submission Open

Keywords: nutrition metabolism; metabolomics; metabolic diseases; lipidomics; proteomics; diet and nutrition; nutritional intervention; diet pattern

(This special issue belongs to the Section Nutrition and Metabolism)

Integration of Emerging Technologies in Metabolite Analysis, 2nd Edition

edited by Kumari Ubhayasekera

submission deadline 31 Mar 2026 | 1 articles | Viewed by 952 | Submission Open

Keywords: liquid chromatography; mass spectrometry; NMR; metabolomics; smaller molecules; supercritical chromatography; gas chromatography

(This special issue belongs to the Section Metabolomic Profiling Technology)

Animal Nutritional Metabolism and Toxicosis Disease, 2nd Edition

edited by

Meng-yao Guo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 833 | Submission Open

Keywords: high-fat food; mammals; fish; metabolic blocks; toxosis; treatment of disease

(This special issue belongs to the Section Animal Metabolism)

Selected Papers from the 4th International Electronic Conference on Metabolomics

edited by

Chi Chen

and

Reza M. Salek

submission deadline 31 Mar 2026 | Viewed by 603 | Submission Open

Keywords: clinical metabolomics; metabolomic technology; data analysis; nutrition; drug discovery; microbial metabolites

Endocrine Disruptors, Nutritional Modulators and Metabolic Pathways in PCOS: From Exposure to Intervention

edited by

Ulisses Moreno Celis

Teresa García Gasca

and Adriana Aguilar Galarza

submission deadline 31 Mar 2026 | Viewed by 370 | Submission Open

Keywords: polycystic ovary syndrome (PCOS); endocrine-disrupting chemicals (EDCs); nutritional epigenetics; metabolic dysfunction; environmental exposure; nutraceuticals; insulin resistance; hormonal imbalance; personalized nutrition; reproductive health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Stable Isotope Labeling and Its Applications in Metabolomics

edited by

Xian Luo

and Chao Wu

submission deadline 31 Mar 2026 | Viewed by 352 | Submission Open

Keywords: metabolomics profiling; LC-MS; lipidomics; isotope labeling; metabolic flux

(This special issue belongs to the Section Metabolomic Profiling Technology)

Advanced Metabolic Profiling via Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Mass Spectrometry: 2nd Edition

edited by

Ana Margarida Araújo

submission deadline 31 Mar 2026 | Viewed by 163 | Submission Open

Keywords: chromatographic methods; mass spectrometry techniques; metabolic profiling; methodological ad-vancements; biomarker discovery; environmental monitoring; food safety and quality; clinical diagnosis; drug development

(This special issue belongs to the Section Advances in Metabolomics)

Advances in Secondary Metabolites: Phytochemical Analysis and Bioactivity Assays—2nd Edition

edited by

Chiara Toniolo

and

Luca Santi

submission deadline 31 Mar 2026 | Viewed by 144 | Submission Open

Keywords: secondary metabolites; phytochemical analysis; biological activity; plant extracts; bioactive compounds; medicinal plants; food plants

(This special issue belongs to the Section Plant Metabolism)

Glycolysis and the Kidney: Mechanistic Insights, Disease Trajectories and Therapeutic Horizons

edited by Pinelopi Kapitsinou

submission deadline 31 Mar 2026 | Viewed by 144 | Submission Open

Keywords: glycolysis; kidney physiology and pathology; mitochondrial metabolism; therapies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Metabolism in Age-Related Diseases: 2nd Edition

edited by

Simona Fenizia

Elettra Barberis

and

Marcello Manfredi

submission deadline 31 Mar 2026 | Viewed by 136 | Submission Open

Keywords: lipid metabolism; metabolic diseases; high-throughput mass spectrometry-based lipidomics; aging; lipid biomarkers; precision medicine

(This special issue belongs to the Section Lipid Metabolism)

Nutritional Metabolism in Obesity: The Role of Support and Health Communication

edited by

Anna Bartosiewicz

submission deadline 31 Mar 2026 | Viewed by 127 | Submission Open

Keywords: obesity; nutritional metabolism; health communication; social support; weight stigma; person-centered care; dietary behavior; psychosocial factors; public health messaging; behavior change

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Metabolites and the Gut Microbiota in Development, Homeostasis, and Diseases

edited by Miriam Di Mattia and

Valentina Petito

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: microbiota; metabolites; gut homeostasis; intestinal barrier; host interactions; inflammation; gut– organ axis

(This special issue belongs to the Section Cell Metabolism)

Biological Activity and Chemical Biodiversity of Plant Secondary Metabolites

edited by

Catherine Cook

submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open

Keywords: secondary metabolites; chemical diversity; biological activities; plant defense; environmental interactions; nutritional and medicinal applications

(This special issue belongs to the Section Plant Metabolism)

Metabolic Dysfunction in Cardiac Adipose Tissue and Valvular Disease

edited by Pedro E. Antunes, Ana Burgeiro and Gonçalo Coutinho

submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open

Keywords: epicardial adipose tissue; valvular disease; coronary artery disease; metabolic syndrome; obesity; diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Lipidomics in MASLD and Related Liver Disorders

edited by Aleksandra Bołdys and Michał Nicze

submission deadline 1 Apr 2026 | 1 articles | Viewed by 932 | Submission Open

Keywords: MASLD; metabolomics; lipidomics; liver disease; biomarkers; metabolic profiling; nonalcoholic fatty liver disease; oxidative stress; mitochondrial dysfunction; systems biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 15 Apr 2026 | 2 articles | Viewed by 4597 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

edited by Miri Park and Jeehwan Choe

submission deadline 15 Apr 2026 | 2 articles | Viewed by 1817 | Submission Open

Keywords: gut microbiota; diet and microbiome; probiotics; prebiotics; circadian rhythms; microbial metabolites; host– microbe interactions; nutritional strategies; gut– brain axis; metabolic health

(This special issue belongs to the Section Cell Metabolism)

Functional Foods and Natural Bioactive Compounds: Strategies to Face Metabolic Syndrome and Related Non-Communicable Diseases—2nd Edition

edited by

Paola Gauffin-Cano

, Sebastián Torres and

Roxana Medina

submission deadline 15 Apr 2026 | Viewed by 212 | Submission Open

Keywords: functional foods; bioactive compounds; fermented foods; fermented beverages; fermented vegetable foods; probiotics; prebiotics; synbiotics; postbiotics; metabolic syndrome; non-communicable diseases

Microbial Regulation of Host Metabolism

edited by

Kippeum Lee

submission deadline 15 Apr 2026 | Viewed by 125 | Submission Open

Keywords: gut microbiota-derived metabolites; short-chain fatty acids (SCFAs); gut hormones; bile acid; probi-otics; postbiotics; gut microbiota; microbiome; physiological function; metabolism balance

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Early-Stage Biomarkers: Metabolomics in Preclinical and Prodromal Disease Detection

edited by

Sonali Mishra

submission deadline 15 Apr 2026 | Viewed by 88 | Submission Open

Keywords: early-stage biomarkers; metabolomics; biomarker validation; untargeted and targeted approaches; cohort studies; multi-omics integration; machine learning / AI; translational research; early disease detection; cancer; neurodegenerative; cerebrovascular; autoimmune; infectious; and psychiatric disorders

(This special issue belongs to the Section Advances in Metabolomics)

Effects of Micronutrients on Human Metabolism

edited by

Lin Xiao

submission deadline 17 Apr 2026 | 1 articles | Viewed by 1593 | Submission Open

Keywords: micronutrients; trace minerals; vitamins; human metabolism; metabolic processes; obesity; diabetes; cardiovascular disease

(This special issue belongs to the Section Food Metabolomics)

Effects of Secondary Plant Metabolites on Human Health

edited by

Beáta Čižmárová

and

Anna Birková

submission deadline 17 Apr 2026 | 1 articles | Viewed by 1346 | Submission Open

Keywords: human health; inflammation; cancer; obesity; antioxidants; phytochemicals; phytoestrogens; secondary metabolites; natural products

(This special issue belongs to the Section Plant Metabolism)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment, 2nd Edition

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 25 Apr 2026 | 1 articles | Viewed by 437 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional disorders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Modulators in Cardiovascular Disease Management

edited by

Syed Siraj A. Quadri

submission deadline 30 Apr 2026 | 4 articles | Viewed by 8021 | Submission Open

Keywords: metabolic modulators; cardiovascular therapeutics; mitochondrial function; cardiometabolic disorders; energy metabolism; metabolic syndrome; therapeutic targets; heart failure; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

edited by

Joshua De Leon

submission deadline 30 Apr 2026 | 4 articles | Viewed by 7488 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

edited by

Sylwia Dzięgielewska-Gęsiak

Teresa Grzelak

and Grzegorz Dziubanek

submission deadline 30 Apr 2026 | 3 articles | Viewed by 6789 | Submission Open

Keywords: nutritional attitudes and behaviors; bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota; dietary supplements; trace elements— Zn; Cu; heavy metals

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 30 Apr 2026 | 3 articles | Viewed by 6678 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Neuronutrition: Metabolomic Insights and Perspectives

edited by

Abraham Wall Medrano

and Rocío Campos Vega

submission deadline 30 Apr 2026 | 1 articles | Viewed by 4831 | Submission Open

Keywords: neuronutrition; neurological disorders; nutrition; functional foods; nutraceutical; nutrition physiology; nutriomics

(This special issue belongs to the Section Nutrition and Metabolism)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3950 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Techniques in Nutrition and Pharmacy Research

edited by

Blake Rushing

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2960 | Submission Open

Keywords: metabolomics; precision nutrition; precision medicine; nutritional biomarkers; pharmacometabolomics; mass spectrometry; metabolic pathways; omics integration; diet– drug interactions; personalized therapeutics

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Profiling in Neurometabolisms

edited by Larissa Daniele Bobermin

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2205 | Submission Open

Keywords: brain; energy homeostasis; glial cells; metabolic disorders; metabolic profiles; neurometabolism; neurons

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1718 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1625 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Diet and Nutrition in Relation to Metabolic Health

edited by

Ivana Šarac

Marija Paunovic

and

Marija Takić

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1440 | Submission Open

Keywords: dietary patterns; nutrients; metabolic syndrome; diet; metabolic health; nutritional biochemistry; dietotherapy; functional food; nutraceuticals

(This special issue belongs to the Section Nutrition and Metabolism)

New Technology and Workflows for Advancing Metabolomics

edited by Lee Andrew Gethings

submission deadline 30 Apr 2026 | Viewed by 298 | Submission Open

Keywords: mass spectrometry; NMR; discovery metabolomics; targeted metabolomics; lipidomics; mass spectrometry imaging; new technology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolism and Reproduction in Animals

edited by

Simona Tafuri

and

Francesca Ciani

submission deadline 30 Apr 2026 | Viewed by 298 | Submission Open

Keywords: metabolism; reproduction; welfare; nutraceuticals; oxidative stress; antioxidants; inflammation; cancer

(This special issue belongs to the Section Animal Metabolism)

Metabolomics of the Eye and Adnexa—2nd Edition

edited by

Seher Yuksel

and

Igor Butovich

submission deadline 30 Apr 2026 | Viewed by 234 | Submission Open

Keywords: metabolomics; metabolites; ocular disease; meibomian gland dysfunction; age-related macular degeneration; glaucoma; diabetic retinopathy; keratoconus; gas chromatography/liquid chromatography– mass spectrometry; nuclear magnetic resonance spectroscopy

(This special issue belongs to the Section Advances in Metabolomics)

Salivary Biomarkers and Metabolites in Pigs

edited by

Fernando Tecles

submission deadline 30 Apr 2026 | Viewed by 203 | Submission Open

Keywords: saliva; biomarkers; welfare and health; animals

(This special issue belongs to the Section Animal Metabolism)

Nature’s Vanguard: Secondary Metabolites and Their Emerging Role in the Evolution of Cancer Therapy

edited by

Thiago André Moura Veiga

and

Edgar Julian Paredes-Gamero

submission deadline 30 Apr 2026 | Viewed by 199 | Submission Open

Keywords: natural compounds; cell signaling; cytotoxic effects; mechanism of action; molecular dereplication; plant; fungi; bacteria; marines; molecular docking

(This special issue belongs to the Section Plant Metabolism)

The Metabolic Genesis of Cardiovascular Disease

edited by

Davide Agnoletti

submission deadline 30 Apr 2026 | Viewed by 160 | Submission Open

Keywords: metabolic disorder; insulin resistance; inflammation; immune system; cardiovascular disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Translational Perspectives on Cancer Energy Metabolism: From Metabolic Mechanisms to Clinical Applications

edited by

Michael Weichhaus

and Helen Turner

submission deadline 30 Apr 2026 | Viewed by 140 | Submission Open

Keywords: cancer metabolism; Warburg effect; metabolic reprogramming; metabolic flux analysis; biomarkers; targeted therapies; clinical translation; population metabolomics; health disparities

(This special issue belongs to the Section Cell Metabolism)

Drug Metabolism and New Drug Development for Cancers—2nd Edition

edited by